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Questions and Answers
What was identified as the primary component of Lewy bodies discovered by Friedrich Lewy?
What was identified as the primary component of Lewy bodies discovered by Friedrich Lewy?
Which role does alpha-synuclein NOT play in neuronal function?
Which role does alpha-synuclein NOT play in neuronal function?
What specific post-translational modification of alpha-synuclein is linked to neurotoxic effects in Lewy bodies?
What specific post-translational modification of alpha-synuclein is linked to neurotoxic effects in Lewy bodies?
In what year was alpha-synuclein associated with Lewy bodies, following Friedrich Lewy's discovery?
In what year was alpha-synuclein associated with Lewy bodies, following Friedrich Lewy's discovery?
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Which of the following statements regarding alpha-synuclein is true?
Which of the following statements regarding alpha-synuclein is true?
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Study Notes
Alpha-Synuclein and Lewy Bodies
- Friedrich Lewy discovered proteinaceous inclusions in neurons in 1912, which were later named Lewy bodies.
- Lewy bodies are primarily composed of abnormal deposits of alpha-synuclein, a protein crucial for neuronal health.
- Alpha-synuclein plays a role in stabilizing neuronal membranes, facilitating presynaptic signaling, and aiding in membrane transport.
- Post-translational modifications of alpha-synuclein, particularly phosphorylation at Ser-129, have been observed in Lewy bodies.
- The phosphorylation of alpha-synuclein at Ser-129 is linked to neurotoxic effects, which may contribute to neurodegenerative diseases.
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Description
This quiz focuses on the role of alpha-synuclein in the formation of Lewy bodies, first described by Friedrich Lewy in 1912. It explores the protein's significance in neuronal stability and its post-translational modifications linked to neurodegenerative diseases.
