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Questions and Answers
What was identified as the primary component of Lewy bodies discovered by Friedrich Lewy?
Which role does alpha-synuclein NOT play in neuronal function?
What specific post-translational modification of alpha-synuclein is linked to neurotoxic effects in Lewy bodies?
In what year was alpha-synuclein associated with Lewy bodies, following Friedrich Lewy's discovery?
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Which of the following statements regarding alpha-synuclein is true?
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Study Notes
Alpha-Synuclein and Lewy Bodies
- Friedrich Lewy discovered proteinaceous inclusions in neurons in 1912, which were later named Lewy bodies.
- Lewy bodies are primarily composed of abnormal deposits of alpha-synuclein, a protein crucial for neuronal health.
- Alpha-synuclein plays a role in stabilizing neuronal membranes, facilitating presynaptic signaling, and aiding in membrane transport.
- Post-translational modifications of alpha-synuclein, particularly phosphorylation at Ser-129, have been observed in Lewy bodies.
- The phosphorylation of alpha-synuclein at Ser-129 is linked to neurotoxic effects, which may contribute to neurodegenerative diseases.
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Description
This quiz focuses on the role of alpha-synuclein in the formation of Lewy bodies, first described by Friedrich Lewy in 1912. It explores the protein's significance in neuronal stability and its post-translational modifications linked to neurodegenerative diseases.
