Alpha and Beta Blockers, Tranquilizers
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Questions and Answers

A veterinarian is treating a dog with hypertension. Which of the following medications would be most appropriate to decrease the dog's blood pressure via vasodilation?

  • Prazosin (correct)
  • Propranolol
  • Timolol
  • Atenolol

A horse has been administered xylazine for sedation. Which of the following drugs would be the MOST appropriate choice to reverse the effects of xylazine?

  • Dexmedetomidine
  • Atipamezole
  • Detomidine
  • Yohimbine (correct)

Following the administration of medetomidine to a canine patient, the veterinarian wants to reverse its effects. Which of the following medications is MOST appropriate?

  • Prazosin
  • Atipamezole (correct)
  • Yohimbine
  • Acepromazine

A client's dog has been diagnosed with a cardiac arrhythmia. Which of the following beta-blockers would be MOST appropriate for treating this condition?

<p>Atenolol (B)</p> Signup and view all the answers

A veterinarian needs to prescribe a medication to calm an anxious dog before a long car ride. Which class of drug is MOST appropriate for this purpose?

<p>Sedative (B)</p> Signup and view all the answers

A dog has been started on phenobarbital for seizure control. How often should the dog's blood levels be checked initially to ensure the drug is within the therapeutic range?

<p>Every 3-4 weeks (D)</p> Signup and view all the answers

A dog is being treated with potassium bromide for seizures. After a dosage adjustment, when should the veterinarian recheck the blood levels of the drug to ensure therapeutic efficacy?

<p>8 weeks (D)</p> Signup and view all the answers

Which of the following is a POTENTIAL side effect associated with potassium bromide use in dogs?

<p>Changes in mentation (C)</p> Signup and view all the answers

Why is potassium bromide generally NOT recommended for use in cats?

<p>It frequently induces an asthma-like lung condition. (A)</p> Signup and view all the answers

A dog is experiencing toxin-induced seizures. Which of the following medications is MOST appropriate for controlling these seizures?

<p>Pentobarbital (C)</p> Signup and view all the answers

Which of the following best describes the mechanism of action of diazepam?

<p>Increases GABA, inhibiting nerve impulse transmission (D)</p> Signup and view all the answers

A veterinarian wants to use a medication that provides sedation and also acts as an anti-emetic. Which of the following drugs would be MOST appropriate?

<p>Acepromazine (B)</p> Signup and view all the answers

Which of the listed drugs is an alpha-2 agonist primarily used for sedation?

<p>Detomidine (D)</p> Signup and view all the answers

A veterinarian administers dexmedetomidine to a dog. What consideration should be taken into account when calculating the appropriate dosage?

<p>The dog's body surface area (BSA) (C)</p> Signup and view all the answers

Which of the following best describes the mechanism of action of alpha-2 agonists?

<p>Bind to alpha-2 receptors and inhibit the release of norepinephrine (C)</p> Signup and view all the answers

A veterinarian notes that a patient is experiencing respiratory depression following anesthesia. Which of the following medications would be MOST appropriate to stimulate the respiratory center?

<p>Doxapram (D)</p> Signup and view all the answers

An elderly cat is experiencing appetite loss. Which of the following drugs can be used as an appetite stimulant in cats?

<p>Midazolam (C)</p> Signup and view all the answers

A dog is administered acepromazine before a surgical procedure. What is the PRIMARY intended effect of this medication?

<p>Sedation (B)</p> Signup and view all the answers

Which drug is LEAST likely to be used to promote vasodilation in a patient?

<p>Atenolol (B)</p> Signup and view all the answers

A veterinarian is treating a dog with cardiac disease and needs to reduce both heart rate and blood pressure. Which medication class is MOST appropriate?

<p>Beta Blockers (D)</p> Signup and view all the answers

Which drug is MOST likely to cause significant respiratory depression as a primary effect?

<p>Xylazine (D)</p> Signup and view all the answers

A veterinarian wishes to induce vomiting in a dog that ingested a toxic substance. Which of the following medications has emetic properties due to its action as an alpha-2 agonist?

<p>Xylazine (B)</p> Signup and view all the answers

What property is unique to detomidine, compared to xylazine, when the two drugs are used for sedation?

<p>Better analgesia (B)</p> Signup and view all the answers

A dog started on phenobarbital for seizure control begins to exhibit signs of liver dysfunction after several months. What adjustments to the treatment plan would be MOST appropriate?

<p>Add potassium bromide to the treatment regimen and reduce phenobarbital dosage (C)</p> Signup and view all the answers

A veterinarian is considering different anti-anxiety medications for a cat with a history of asthma, which medication is the SAFEST choice?

<p>Diazepam (C)</p> Signup and view all the answers

Which medication is LEAST likely to be used for long-term seizure management?

<p>Pentobarbital (C)</p> Signup and view all the answers

An animal is given an alpha-2 agonist. What is the MOST likely effect one would observe?

<p>Sedation (C)</p> Signup and view all the answers

A dog is being treated concurrently with phenobarbital and potassium bromide. What is the most important consideration for the veterinarian?

<p>Monitoring both mentation and motor ability (D)</p> Signup and view all the answers

Which of the following drugs is LEAST likely to be used alone to treat anxiety?

<p>Acepromazine (B)</p> Signup and view all the answers

What is the MOST important monitoring parameter for a patient on long-term propranolol therapy?

<p>Heart rate (A)</p> Signup and view all the answers

A veterinarian needs a medication that provides analgesia as well as sedation for a painful procedure for horses. Which of the following medications is BEST suited?

<p>Detomidine (B)</p> Signup and view all the answers

A veterinarian notices that a dog on long-term phenobarbital therapy has elevated liver enzymes. What change in the treatment plan would be MOST appropriate?

<p>Add in potassium bromide and reduce the dose of phenobarbital (C)</p> Signup and view all the answers

How does diazepam affect neurotransmitter activity in the brain?

<p>Increases GABA activity which inhibits nerve impulse transmission (D)</p> Signup and view all the answers

How does the route of administration of phenobarbital impact its onset of action?

<p>IV route allows for more rapid onset of action (D)</p> Signup and view all the answers

If you are administering pentobarbital to a patient, what route is MOST appropriate?

<p>Intravenous (D)</p> Signup and view all the answers

A horse is given Dormosedan. The user knows that this drug results in better analgesia than Xylazine. What receptor does this drug bind to?

<p>Alpha-2 receptors (B)</p> Signup and view all the answers

Which of the following medications is frequently used to treat glaucoma?

<p>Timolol (A)</p> Signup and view all the answers

Upon administration of an alpha-2 agonist, what effect would likely be observed?

<p>Inhibit the release of norepinephrine (A)</p> Signup and view all the answers

Which of the following medications requires monitoring of drug blood levels approximately 8 weeks after starting the medication or after a dose change?

<p>Potassium bromide (A)</p> Signup and view all the answers

Which drug is contraindicated for use in cats because it may cause an asthma-like lung condition in approximately one-third of patients?

<p>Potassium Bromide (A)</p> Signup and view all the answers

What is the primary mechanism of action of Doxapram, and what condition is it most often used to treat?

<p>Respiratory stimulant; respiratory depression (C)</p> Signup and view all the answers

Which class of drugs is MOST likely to be used as both an anti-anxiety medication and an appetite stimulant, particularly in cats?

<p>Benzodiazepines (C)</p> Signup and view all the answers

A client is prescribed timolol eye drops for their dog. What condition does this dog MOST likely have.

<p>Glaucoma (A)</p> Signup and view all the answers

Flashcards

Alpha Blockers

Cause vasodilation and decrease blood pressure.

Phenoxybenzamine

Vasodilator used to treat hypertension.

Prazosin

Vasodilator used to treat heart failure and hypertension.

Acepromazine

Vasodilator commonly used as a tranquilizer in veterinary medicine.

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Droperidol

Vasodilator that is also a tranquilizer.

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Yohimbine

Reversal agent for xylazine (an alpha 2 agonist).

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Atipamezole

Reversal agent for medetomidine, detomidine, and dexmedetomidine (alpha 2 agonists).

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Beta Blockers

Decrease heart rate and blood pressure.

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Propranolol

Used to treat cardiac arrhythmias and disease.

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Atenolol

Used to treat cardiac arrhythmias and disease.

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Timolol

Used to treat glaucoma.

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Tranquilizer

Calming agent that reduces anxiety and aggression.

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Sedative

Decreases irritability and excitement.

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Anti-anxiety

Reduces anxiety.

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Phenobarbital Monitoring

Drug blood levels should be checked 3-4 weeks after starting or changing the dose, then approximately every 6 months.

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Phenobarbital Safety and Monitoring

Has a lower margin of safety than other AEDs and can affect liver health; liver function should be checked approximately every 6 months.

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Potassium Bromide Monitoring

Drug blood levels checked ~8 weeks post start or dose change, then ~ every 6 months.

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Potassium Bromide Safety

Has a lower margin of safety than other AEDs; can affect mental state, motor ability and appetite.

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Diazepam Mechanism of Action

Increases GABA (gamma-aminobutyric acid), which inhibits nerve impulse transmission.

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Phenobarbital Description

Long-acting barbiturate, administered orally or intravenously, that depresses the motor center of the cerebral cortex.

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Potassium Bromide (KBr) Use and Caution

Adjunct anticonvulsant, NOT for use in cats due to asthma-like lung condition in 1/3 of feline patients.

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Pentobarbital

Used to treat toxin-induced seizures and for euthanasia.

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Phenothiazine Derivatives Uses

Sedation; anti-emetic.

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Diazepam (Valium®) Use

Anti-anxiety, anticonvulsant, muscle relaxation, appetite stimulant (cats-OLD).

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Zolazepam (Telazol®) Use

anti-anxiety, anticonvulsant, muscle relaxation, appetite stimulant (cats-OLD)

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Midazolam Use

Anti-anxiety, anticonvulsant, muscle relaxation, appetite stimulant (cats-OLD)

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Xylazine Reversal Agents

Reversals = yohimbine (Yobine®) & tolazoline (Tolazine®)

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Alpha-2 Agonists Use

Sedation; emetic.

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Alpha-2 Agonists Mechanism

Bind to alpha-2 receptors = inhibit release NT norepinephrine.

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Detomidine (Dormosedan®)

Better analgesia than Xylazine.

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Dexmedetomidine (Dexdomitor®)

In dogs [dosage via BSA]/cats for sedative & analgesia

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Doxapram

Stimulates respiratory center in medulla Primarily to treat respiratory depression or arrest.

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Study Notes

Alpha Blockers

  • Cause vasodilation and decrease blood pressure.
  • Phenoxybenzamine is a vasodilator used to treat hypertension.
  • Prazosin is a vasodilator that treats heart failure and hypertension.
  • Acepromazine is a vasodilator.
  • Droperidol is a vasodilator.
  • Yohimbine reverses the effects of xylazine (an alpha 2 agonist).
  • Atipamezole reverses the effects of medetomidine, detomidine, and dexmedetomidine (alpha 2 agonists).

Beta Blockers

  • Decrease heart rate and blood pressure.
  • Propranolol treats cardiac arrhythmias and disease.
  • Atenolol treats cardiac arrhythmias and disease.
  • Timolol treats glaucoma.

Tranquilizers, Sedatives & Anti-Anxiety Meds

  • Tranquilizers are calming and reduce anxiety and aggression.
  • Sedatives decrease irritability and excitement.
  • Anti-anxiety medications reduce anxiety.

Phenobarbital

  • Monitor drug blood levels 3-4 weeks after starting or changing the dose, then approximately every 6 months.
  • Has a lower margin of safety compared to other AEDs and can affect liver health.
  • Liver function should be monitored approximately every 6 months, checking liver enzymes and proteins.

Potassium Bromide

  • Drug blood levels should be monitored approximately 8 weeks after starting or changing the dose, then approximately every 6 months.
  • Lower margin of safety than other AEDs, and can affect mentation, motor ability, and appetite.

Diazepam (Valium®, a benzodiazepine)

  • Increases GABA (gamma-aminobutyric acid), which inhibits nerve impulse transmission.
  • GABA is an inhibitory neurotransmitter.

Phenobarbital

  • It is a long-acting barbiturate that can be administered PO or IV.
  • Depresses the motor center of the cerebral cortex.

Potassium Bromide (KBr)

  • Use as an adjunct medication

Use of Potassium Bromide in Cats

  • Do NOT use in cats as it may cause an asthma-like lung condition in 1/3 of treated patients.

Pentobarbital (Nembutal®, a barbiturate)

  • Used to treat toxin-induced seizures and for euthanasia.

Phenothiazine Derivatives

  • Acepromazine maleate is a phenothiazine derivative.
  • Used for sedation and as an anti-emetic.

Diazepam (Valium®)

  • Used for anti-anxiety, anticonvulsant, muscle relaxation, and appetite stimulation (especially in older cats).

Other "-zolam" Drugs

  • Zolazepam (Telazol®) is used for anti-anxiety, anticonvulsant, muscle relaxation, and appetite stimulation (especially in older cats).
  • Midazolam is used for anti-anxiety, anticonvulsant, muscle relaxation, and appetite stimulation (especially in older cats).

Xylazine

  • Can be reversed with yohimbine (Yobine®) and tolazoline (Tolazine®).

Alpha-2 Agonists

  • Used for sedation and as an emetic.
  • They bind to alpha-2 receptors and inhibit the release of the neurotransmitter norepinephrine.

Detomidine (Dormosedan®)

  • Offers better analgesia than Xylazine.

Dexmedetomidine (Dexdomitor®)

  • Used for sedation and analgesia in dogs (dosage via BSA) and cats.

Doxapram

  • Stimulates the respiratory center in the medulla.
  • Primarily used to treat respiratory depression or arrest.

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Description

Overview of alpha-blockers and beta-blockers, including their mechanisms of action and common uses, such as vasodilation and decreasing blood pressure. Also covers tranquilizers, sedatives, and anti-anxiety medications. Monitoring of phenobarbital drug levels is also discussed.

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