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Questions and Answers
Alpha-1 selective adrenergic antagonists primarily work by blocking which receptor sites?
Alpha-1 selective adrenergic antagonists primarily work by blocking which receptor sites?
- Beta1-receptor sites
- Beta2-receptor sites
- Presynaptic alpha2-receptor sites
- Postsynaptic alpha1-receptor sites (correct)
What is a primary effect of alpha-1 selective adrenergic antagonists on vascular tone?
What is a primary effect of alpha-1 selective adrenergic antagonists on vascular tone?
- Decreased vascular tone (vasodilation) (correct)
- Increased vascular tone (vasoconstriction)
- Variable effect on vascular tone
- No effect on vascular tone
Which of the following is a common suffix found in the generic names of alpha-1 selective adrenergic antagonists?
Which of the following is a common suffix found in the generic names of alpha-1 selective adrenergic antagonists?
- -pril
- -olol
- -osin (correct)
- -statin
Which of the following conditions is listed as a caution when prescribing alpha-1 selective adrenergic antagonists?
Which of the following conditions is listed as a caution when prescribing alpha-1 selective adrenergic antagonists?
Dizziness is a common adverse effect associated with alpha-1 selective adrenergic antagonists. What is the cause of the dizziness?
Dizziness is a common adverse effect associated with alpha-1 selective adrenergic antagonists. What is the cause of the dizziness?
Which of the following is a potential adverse effect of alpha-1 selective adrenergic antagonists related to vision?
Which of the following is a potential adverse effect of alpha-1 selective adrenergic antagonists related to vision?
What effect do alpha-1 selective adrenergic antagonists have on smooth muscle of the bladder and prostate?
What effect do alpha-1 selective adrenergic antagonists have on smooth muscle of the bladder and prostate?
Which of the following is the brand name for tamsulosin, an alpha-1 selective adrenergic antagonist?
Which of the following is the brand name for tamsulosin, an alpha-1 selective adrenergic antagonist?
Which of the following is a potential adverse effect of alpha-1 selective adrenergic antagonists in males?
Which of the following is a potential adverse effect of alpha-1 selective adrenergic antagonists in males?
What is a common gastrointestinal adverse effect associated with alpha-1 selective adrenergic antagonists?
What is a common gastrointestinal adverse effect associated with alpha-1 selective adrenergic antagonists?
Flashcards
Alpha-1 Selective Adrenergic Antagonists
Alpha-1 Selective Adrenergic Antagonists
Block postsynaptic alpha1-receptor sites, leading to vasodilation and smooth muscle relaxation in the bladder and prostate.
Effects of Alpha-1 Blockade
Effects of Alpha-1 Blockade
Reduced vascular tone (vasodilation) and relaxation of smooth muscle in the bladder and prostate.
Common Adverse Effects of Alpha-1 Blockers
Common Adverse Effects of Alpha-1 Blockers
Dizziness, drowsiness, headache, blurry vision, hypotension, erectile dysfunction, nausea/vomiting.
Cautions for Alpha-1 Blockers
Cautions for Alpha-1 Blockers
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Study Notes
- Alpha-1 selective adrenergic antagonists work by blocking postsynaptic alpha1-receptor sites.
- These antagonists lead to decreased vascular tone, causing vasodilation.
- They also relax smooth muscle in the bladder and prostate.
- Generic names of these medications end in "OSIN".
- Specific examples include: Alfuzosin, doxazosin, prazosin, silodosin, tamsulosin (Flomax), and terazosin.
- Use with caution in patients with heart failure or who are pregnant.
- Adverse effects include: dizziness, drowsiness, headache, blurry vision, hypotension, erectile dysfunction, impotency, nausea, and vomiting.
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