Allergic Rhinitis Study Guide

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Questions and Answers

What is a common trigger for perennial allergic rhinitis?

  • Certain foods
  • Chemical fumes
  • House dust mites (correct)
  • Pollen from trees

How is episodic allergic rhinitis defined?

  • Chronic symptoms year-round
  • Exposure to allergens on a sporadic basis (correct)
  • Symptoms affecting daily activities
  • Symptoms present for more than a month

What is the duration criterion for persistent allergic rhinitis?

  • Symptoms occurring less than 10 times a year
  • Symptoms present only in spring
  • More than 4 days per week for 1 month (correct)
  • Less than 4 days per week for 1 month

Mild allergic rhinitis is characterized by an impact on which of the following?

<p>No impact on quality of life (B)</p> Signup and view all the answers

Which of the following is a major pathogenic mechanism for allergic rhinitis?

<p>Increased IgE antibody production (A)</p> Signup and view all the answers

What happens when pollen enters the nose in the context of allergic rhinitis?

<p>It gets picked up by a dendritic cell (B)</p> Signup and view all the answers

The activation of T cells in allergic rhinitis leads to the production of which substances?

<p>Cytokines (D)</p> Signup and view all the answers

What is the role of IgE antibodies in allergic rhinitis?

<p>To bind to mast cells and trigger responses (A)</p> Signup and view all the answers

What causes the sneezing reflex in allergic rhinitis?

<p>Histamine irritation of the sensory nerve (D)</p> Signup and view all the answers

What major role do leukotrienes play in allergic rhinitis?

<p>Contributing to nasal mucosal swelling (C)</p> Signup and view all the answers

Which of the following is NOT a symptom of allergic rhinitis?

<p>Fever (D)</p> Signup and view all the answers

What is the aim of treatment for allergic rhinitis?

<p>Alleviation of symptoms and daily living difficulties (B)</p> Signup and view all the answers

Which test is used to diagnose allergic rhinitis?

<p>Skin prick test for allergen-specific IgE (B)</p> Signup and view all the answers

What should be done if there is no improvement in symptoms after 5 days of treatment?

<p>Refer to a doctor for other therapy (D)</p> Signup and view all the answers

What effect does histamine have on blood capillaries during an allergic reaction?

<p>Causes dilation and leakage (C)</p> Signup and view all the answers

What specific symptoms are required for a definite diagnosis of allergic rhinitis?

<p>Sneezing, nasal itching, and nasal blockage (A)</p> Signup and view all the answers

What is Azelastine primarily used for?

<p>Nasal spray for allergic rhinitis (A)</p> Signup and view all the answers

When should treatment with Azelastine begin for optimal results?

<p>2–3 weeks before the hay fever season starts (D)</p> Signup and view all the answers

What is a potential side effect of prolonged use of topical decongestants?

<p>Increased nasal congestion (D)</p> Signup and view all the answers

Which combination is beneficial for treating intermittent eye symptoms?

<p>Eye drops containing an antihistamine and decongestant (A)</p> Signup and view all the answers

What is allergic rhinitis primarily characterized by?

<p>Inflammatory process of the nasal mucosa (A)</p> Signup and view all the answers

What should be noted about the use of steroid nasal sprays?

<p>Their effects are maximized with regular use. (C)</p> Signup and view all the answers

Which demographic should avoid using steroid nasal sprays?

<p>Pregnant women (B)</p> Signup and view all the answers

Which of the following is a common symptom of allergic rhinitis?

<p>Nasal discharge and sneezing (A)</p> Signup and view all the answers

What effect do decongestants generally have on nasal congestion?

<p>They provide short-term relief (C)</p> Signup and view all the answers

What is the duration criteria for the symptoms of allergic rhinitis?

<p>Symptoms persisting for at least one hour a day for two consecutive days (A)</p> Signup and view all the answers

What advice should be given to patients using Azelastine nasal spray?

<p>Keep the head upright during use (D)</p> Signup and view all the answers

Which of the following classifications of allergic rhinitis is NOT recognized?

<p>Chronic allergic rhinitis (B)</p> Signup and view all the answers

What is the major cause of allergic rhinitis symptoms?

<p>Inflammatory response to allergens (D)</p> Signup and view all the answers

Which allergens are commonly associated with seasonal allergic rhinitis?

<p>Grass pollens and tree pollens (A)</p> Signup and view all the answers

Why is timely diagnosis of allergic rhinitis important?

<p>It ensures correct management based on guidelines. (B)</p> Signup and view all the answers

What impact does allergic rhinitis have on affected individuals?

<p>It is a major cause of absenteeism in school and work. (C)</p> Signup and view all the answers

What is the role of communication with patients in pharmacotherapy management?

<p>It improves patient satisfaction and quality of life. (A)</p> Signup and view all the answers

Which of the following antihistamines is considered a first-generation antihistamine?

<p>Chlorpheniramine (B)</p> Signup and view all the answers

What type of antihistamines are primarily recommended for patients with mild to moderate intermittent symptoms?

<p>Second-generation antihistamines (A)</p> Signup and view all the answers

For pet allergies, what is the recommended action?

<p>Avoid contact with causative pets. (B)</p> Signup and view all the answers

What is an effective method to reduce dust mites in the home?

<p>Using a dehumidifier. (C)</p> Signup and view all the answers

What characteristics are common with first-generation antihistamines?

<p>They cause more sedation compared to second-generation antihistamines. (B)</p> Signup and view all the answers

How should treatment choices be made for allergic rhinitis patients?

<p>Based rationally on symptoms and patient history. (A)</p> Signup and view all the answers

Which scenario indicates that a patient may need to see a doctor for allergic rhinitis?

<p>Symptoms do not respond to OTC treatment. (B)</p> Signup and view all the answers

What characteristic is true about nasal steroids?

<p>They are effective only at the site of administration. (C)</p> Signup and view all the answers

What is a key feature of Sodium Cromoglycate?

<p>It should be started well in advance of the hay fever season. (A)</p> Signup and view all the answers

Which of the following is an adverse effect of Sodium Cromoglycate?

<p>Nasal irritation (D)</p> Signup and view all the answers

How should Cromoglycate eye drops be administered for optimal effectiveness?

<p>Four times a day continuously. (B)</p> Signup and view all the answers

What advice should be given to drivers during high pollen concentration?

<p>Keep windows and air vents closed. (C)</p> Signup and view all the answers

What is the primary purpose of using Sodium Cromoglycate as a treatment?

<p>To stabilize mast cells and prevent symptoms. (C)</p> Signup and view all the answers

When should patients consider seeking referral for allergic rhinitis?

<p>When there is persistent nasal blockage. (A)</p> Signup and view all the answers

Which of the following is NOT commonly recommended for managing allergic rhinitis?

<p>Infrequent use of treatments. (D)</p> Signup and view all the answers

Flashcards

Allergic Rhinitis (AR)

An inflammatory process of the nasal mucosa, typically IgE-mediated, triggered by environmental allergens, causing symptoms like discharge, itching, sneezing, and obstruction.

Seasonal AR

Allergic rhinitis triggered by allergens like pollens (grass, trees) and molds, occurring seasonally.

Perennial AR

Allergic rhinitis caused by indoor allergens, such as dust mites and pet dander, lasting year-round.

IgE-mediated

An immune response involving Immunoglobulin E antibodies that are important for the allergic response in this case.

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Histamine Release

The release of histamine from cells, a key chemical messenger in an inflammatory response, triggered by allergens.

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Environmental Allergens

Substances in the environment that trigger an allergic response in susceptible individuals.

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Symptom Duration

Symptoms lasting at least one hour a day for at least two consecutive days, important for diagnosis.

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Impact on Quality of Life

Allergic rhinitis can significantly affect a person's daily life (school, work, social activities).

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Perennial Allergic Rhinitis

Allergic rhinitis symptoms present year-round, often caused by indoor allergens like dust mites, pet dander, or feathers.

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Episodic Allergic Rhinitis

Allergic rhinitis triggered by specific airborne allergens, often on a sporadic basis, like visiting a pet-owner's home.

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Intermittent AR

Allergic rhinitis symptoms lasting less than 4 days a week or less than 4 weeks in a year.

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Persistent AR

Allergic rhinitis with symptoms for more than 4 days a week and more than 1 month in a year.

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Mild AR

Allergic rhinitis with no significant impact on daily activities, sleep, school, or work.

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Moderate/Severe AR

Allergic rhinitis with a negative impact on one or more aspects of daily life (e.g., activities, sleep, school/work).

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Allergic Rhinitis Pathogenesis

The development of allergic rhinitis is linked to genetic factors and the body's antibody production (IgE).

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Dendritic Cell

An immune cell that ingests foreign particles, like pollen, and presents them to other immune cells for recognition.

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Pharmacotherapy Combinations

Combining allergy medications based on severity and type for improved patient experience.

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Allergen Avoidance

Reducing exposure to triggers of allergic reactions, including eliminating antigens and avoiding contact.

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Mild/Moderate Allergy

Allergy symptoms that are not severe and occur occasionally or persistently.

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Antihistamines (First-Gen)

Older antihistamines that reduce sneezing and runny nose but can cause drowsiness.

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Antihistamines (Second-Gen)

Newer antihistamines that reduce allergy symptoms with less drowsiness.

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OTC Antihistamines

Over-the-counter antihistamines used to treat allergy symptoms.

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Nasal Steroids

Medications applied to the nose to reduce inflammation and relieve allergy symptoms.

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Dehumidifier Use

Using a dehumidifier to lower humidity, reducing dust mites.

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Mast Cell Degranulation

Release of histamine by mast cells when allergens are encountered again, triggering an inflammatory response.

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Histamine's Role

Histamine causes blood vessel dilation and leakage, leading to symptoms like runny nose and swelling.

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Sneezing Trigger

Histamine irritates nerve endings in the nasal passages, sending signals to the brain that triggers sneezing.

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Watery Rhinorrhea

Runny nose caused by the leaky blood vessels allowing fluid to build up, which the nose must drain.

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Nasal Swelling

Inflammation in the nasal passage causes fluid buildup and swelling, leading to a stuffy nose

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Allergic Rhinitis Diagnosis

Diagnosis requires three key symptoms (sneezing, runny nose, stuffy nose), nasal eosinophil tests, and identifying the specific allergens.

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Allergic Rhinitis Treatment Aim

To relieve symptoms to reduce discomfort associated with daily life.

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Allergy Timescale

Improved symptoms typically appear within a few days; if no improvement after five days, consult a doctor for further care.

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Loratadine's effect on drowsiness

Loratadine is less likely to cause drowsiness than other antihistamines, but sedation is still a small possibility.

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Nasal Spray Use

Azelastine nasal spray is often used for mild or intermittent hay fever symptoms in adults and children over 5 years old.

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Decongestant Use Duration

Short-term use of oral/topical decongestants is okay for reducing nasal congestion, but prolonged use can cause rebound congestion. Avoid prolonged usage.

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Eye Drops with Decongestant

Eye drops with both antihistamine and decongestant are beneficial for intermittent eye symptoms, reducing redness and irritation.

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Steroid Nasal Sprays Use

Beclometasone and fluticasone nasal sprays are used for seasonal allergic rhinitis, especially for moderate to severe, continuous symptoms. Regular use is crucial.

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Steroid Spray Duration Limit

Steroid nasal sprays (beclometasone/fluticasone) are safe for people over 18, but not for pregnant women or glaucoma patients. Limited to 3 months.

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Side effects of nasal sprays

Steroid nasal sprays may occasionally cause nose/throat dryness, irritation or bleeding but side effects are uncommon.

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Hay Fever Season Treatment Timing

Treatment for hay fever, including nasal sprays, should begin 2-3 weeks before the start of the season to provide proactive symptom relief and prevent significant issues.

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Nasal Steroids

Medications sprayed into the nose to reduce inflammation and allergy symptoms.

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Sodium Cromoglycate

A preventative medicine used to manage seasonal allergies, effective for local symptoms

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Allergic Rhinitis Triggers

Substances like pollen, dust mites, or pet dander that cause an allergic reaction in the nose

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Allergy Referral Triggers

Symptoms like wheezing, ear pain, or purulent eye discharge that suggest possible conditions beyond simple allergy

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Potent Effects (Nasal Steroids)

Nasal steroids cause significant effects, powerful at reducing inflammation.

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Rapid Effects (Nasal Steroids)

Nasal steroids reduce symptoms relatively quickly after use.

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Adverse Effects (Nasal Steroids)

Side effects with nasal steroids are generally few, and not bothersome

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Continuous Administration (Sodium Cromoglycate)

Regular use of sodium cromoglycate helps for better and more long-term control of the issues in allergies

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Study Notes

Allergic Rhinitis (AR)

  • AR is an inflammatory process of the nasal mucosa, typically IgE-mediated, elicited by environmental allergens.
  • Symptoms include nasal discharge, nasal itching, sneezing, and nasal obstruction.
  • The disease course involves symptoms lasting at least an hour a day for at least two consecutive days, and is reversible spontaneously or with treatment.

Common Causes of Allergic Rhinitis

  • Dust mites
  • Dust and pollen
  • Molds
  • Pets
  • Foods and beverages
  • Airborne irritants

Pathogenic Mechanisms of Allergic Rhinitis

  • Allergens trigger an inflammatory response involving the release of histamine.
  • Dendritic cells capture allergens and present them to T cells.
  • Activated T cells stimulate B cells to produce IgE antibodies.
  • IgE antibodies bind to mast cells, releasing histamine.
  • Histamine causes blood vessel dilation, increased fluid, and immune cell recruitment.
  • Nasal mucosal swelling and irritation leads to symptoms like sneezing and rhinorrhea.

Classifications of Allergic Rhinitis

According to Etiology

  • Seasonal allergic rhinitis (hay fever)
  • Perennial allergic rhinitis
  • Episodic allergic rhinitis (EAR)

According to Duration

  • Intermittent allergic rhinitis (symptoms less than 4 days/week or less than a month/year)

  • Persistent allergic rhinitis (symptoms for ≥ 4 days/week and ≥ 1 month/year)

  • Symptoms are also classified as either mild, moderate, or severe, based on the impact on daily activities, school/work attendance, sleep, and need for therapy.

Diagnosis of Allergic Rhinitis

  • Three key symptoms: sneezing, nasal itching, watery rhinorrhea, and nasal blockage.
  • Positive nasal eosinophil tests
  • Identifying causative allergens through skin reactions or serum allergen-specific IgE antibody measurements .

Treatment Timescale

  • Improvement should be expected within a few days.
  • If no improvement after 5 days, the patient should be referred for further evaluation and treatment.

Aim of Treatment

  • Alleviate symptoms and remove everyday life difficulties.
  • Treatment choice based on severity, disease type, and lifestyle.

Management of Allergic Rhinitis

Non-Pharmacological Treatment

  • Combinations of pharmacotherapies tailored to severity, and patient communication.
  • Elimination and avoidance of antigens.
  • Lowering humidity with dehumidifiers to reduce dust mites.
  • Avoidance of pets and keeping pets clean in patients with pet allergies.

Pharmacological Treatment

  • Options include antihistamines, nasal steroids, and mast cell stabilizers.
  • OTC antihistamines / steroid nasal sprays are effective for mild and moderate cases.
  • Prescription-level medications may be involved in severe or more persistent cases.

Antihistamines

  • First-generation: can be effective but can cause sedation.
  • Second-generation: less sedating, effective for hay fever.

Topical antihistamines

  • Azelastine nasal spray is a good choice for mild and intermittent cases.
  • Treatment is best introduced 2-3 weeks before hay fever season.

Decongestants

  • Oral and topical decongestants can help with nasal congestion.
  • Topical decongestants should be used for no more than a week due to a risk of rebound congestion.

Steroid nasal sprays

  • Beclomethasone and fluticasone nasal sprays are effective for moderate to severe symptoms.
  • Regular use is essential for long term effects.
  • Should not be recommended for pregnant women or those with glaucoma.

Mast cell stabilizers

  • Sodium cromoglycate can be effective in managing symptoms (prophylactic).
  • Two-week prolonged administration is needed for sufficient clinical effects.

Further Advice

  • Close car windows during pollen season.
  • Maintain household cleanliness to minimize dust mites.

When to Refer

  • Wheezing/shortness of breath
  • Tightness of chest
  • Painful ear
  • Painful sinuses
  • Purulent conjunctivitis
  • Failed medication response

Learning Objectives (from provided text)

  • Know what is allergic rhinitis.
  • Define what common cause of allergic rhinitis.
  • Identify Pathogenic mechanisms of allergic rhinitis.
  • Know classification of allergic rhinitis.
  • Define how to manage allergic rhinitis.
  • Define trigger points indicative for referral.

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