18 Questions
Methotrexate is primarily metabolized in the kidney
False
Vinca alkaloids are mainly used in treating brain tumors due to their ability to cross the blood-brain barrier
False
Mustine drugs like cyclophosphamide form inter-strand cross links in DNA leading to defective DNA and abnormal function
True
Vinca alkaloids are known for causing hemorrhagic cystitis as a common adverse effect
False
Methotrexate is commonly used in the treatment of breast and ovarian carcinoma
False
Mustine drugs like nitrosoureas show efficacy in treating lymphoma and multiple myeloma
True
Vinca alkaloids are derived from the periwinkle plant (Catharantus roseus).
True
Methotrexate is a Vinca alkaloid.
False
Nitrogen mustards are examples of alkylating agents.
True
Vinca alkaloids bind to α-tubulin during mitosis of the cell cycle.
False
A therapeutic effect is usually achieved by killing dormant cells.
False
Early treatment in cancer is less critical when the tumour burden is high.
False
Vincristine is primarily excreted via urine
False
Vinblastine is more neurotoxic than Vincristine
False
Folate is not required for the synthesis of purine nucleotides
False
Vincristine has a longer half-life than Vinblastine
False
Mustine drugs like cyclophosphamide mainly affect DNA by forming intrastrand cross-links
False
Methotrexate is metabolized primarily in the liver
False
Test your knowledge on the mechanism of action of alkylating agents known as nitrogen mustards, including Cyclophosphamide and its metabolites. Learn how these agents cross-link DNA to induce defective DNA and abnormal cellular functions.
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