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Questions and Answers
Methotrexate is primarily metabolized in the kidney
Methotrexate is primarily metabolized in the kidney
False (B)
Vinca alkaloids are mainly used in treating brain tumors due to their ability to cross the blood-brain barrier
Vinca alkaloids are mainly used in treating brain tumors due to their ability to cross the blood-brain barrier
False (B)
Mustine drugs like cyclophosphamide form inter-strand cross links in DNA leading to defective DNA and abnormal function
Mustine drugs like cyclophosphamide form inter-strand cross links in DNA leading to defective DNA and abnormal function
True (A)
Vinca alkaloids are known for causing hemorrhagic cystitis as a common adverse effect
Vinca alkaloids are known for causing hemorrhagic cystitis as a common adverse effect
Methotrexate is commonly used in the treatment of breast and ovarian carcinoma
Methotrexate is commonly used in the treatment of breast and ovarian carcinoma
Mustine drugs like nitrosoureas show efficacy in treating lymphoma and multiple myeloma
Mustine drugs like nitrosoureas show efficacy in treating lymphoma and multiple myeloma
Vinca alkaloids are derived from the periwinkle plant (Catharantus roseus).
Vinca alkaloids are derived from the periwinkle plant (Catharantus roseus).
Methotrexate is a Vinca alkaloid.
Methotrexate is a Vinca alkaloid.
Nitrogen mustards are examples of alkylating agents.
Nitrogen mustards are examples of alkylating agents.
Vinca alkaloids bind to α-tubulin during mitosis of the cell cycle.
Vinca alkaloids bind to α-tubulin during mitosis of the cell cycle.
A therapeutic effect is usually achieved by killing dormant cells.
A therapeutic effect is usually achieved by killing dormant cells.
Early treatment in cancer is less critical when the tumour burden is high.
Early treatment in cancer is less critical when the tumour burden is high.
Vincristine is primarily excreted via urine
Vincristine is primarily excreted via urine
Vinblastine is more neurotoxic than Vincristine
Vinblastine is more neurotoxic than Vincristine
Folate is not required for the synthesis of purine nucleotides
Folate is not required for the synthesis of purine nucleotides
Vincristine has a longer half-life than Vinblastine
Vincristine has a longer half-life than Vinblastine
Mustine drugs like cyclophosphamide mainly affect DNA by forming intrastrand cross-links
Mustine drugs like cyclophosphamide mainly affect DNA by forming intrastrand cross-links
Methotrexate is metabolized primarily in the liver
Methotrexate is metabolized primarily in the liver
