Alkaloids of Claviceps purpurea
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Questions and Answers

Which of the following is the chief alkaloid found in the simple amides of lysergic acid group?

  • Ergine
  • Ergotamine
  • Ergocristine
  • Ergonovine (ergobasine, ergometrine) (correct)
  • Which group of alkaloids constitutes approximately 80% of the total alkaloids in Claviceps purpurea?

  • Lysergic acid derivatives
  • Ergopeptines (correct)
  • Clavines
  • Ergotoxines
  • Which of the following is a principal alkaloid included in the ergopeptines group?

  • Ergonovine
  • Ergovaline
  • Ergine
  • Ergotamine (correct)
  • What type of solution are alkaloids derived from lysergic acid sensitive to?

    <p>UV radiation</p> Signup and view all the answers

    Which alkaloid is soluble in water and represents about 20% of the total alkaloids?

    <p>Ergonovine (ergobasine, ergometrine)</p> Signup and view all the answers

    Which color reaction can be used for the quantitation of ergot alkaloids?

    <p>4-dimethylaminobenzaldehyde under acidic conditions to give a blue color (van Urk reaction)</p> Signup and view all the answers

    Which alkaloid is a potent vasoconstrictor acting by stimulation of the alpha-adrenergic receptors or the serotonergic receptors in the case of the cranial blood vessels?

    <p>Ergotamine</p> Signup and view all the answers

    Which alkaloid is a potent oxytocic that increases basal tone, and the frequency and strength of uterine contractions, particularly linked to the stimulation of the alpha-adrenergic receptors in the myometrium?

    <p>Ergonovine</p> Signup and view all the answers

    Which method can be used for the analysis of complex alkaloid mixtures such as total alkaloids, fermentation media, and pharmaceutical formulations?

    <p>HPLC with UV detection</p> Signup and view all the answers

    Which structural analogy explains the affinity of ergot alkaloids and their derivatives for endogenous amine receptors and their ability to exert agonistic or antagonistic effects on those receptors?

    <p>Structural similarity with endogenous amines</p> Signup and view all the answers

    Which alkaloid is thought to be linked to the stimulation of the alpha-adrenergic receptors in the myometrium, resulting in increased basal tone and frequency of uterine contractions?

    <p>Ergometrine</p> Signup and view all the answers

    Which alkaloid is a potent vasoconstrictor acting by stimulation of the alpha-adrenergic receptors or the serotonergic receptors in the cranial blood vessels?

    <p>Ergotamine</p> Signup and view all the answers

    Which alkaloid is soluble in water and represents about 20% of the total alkaloids?

    <p>Ergotamine</p> Signup and view all the answers

    Which alkaloid is a structural analog of endogenous amines such as noradrenaline, dopamine, and serotonin, and has the ability to exert agonistic or antagonistic effects on their receptors?

    <p>Lysergic acid</p> Signup and view all the answers

    Which method can be used for the analysis of complex alkaloid mixtures such as total alkaloids, fermentation media, and pharmaceutical formulations?

    <p>HPLC (UV detection)</p> Signup and view all the answers

    Which alkaloid is a potent vasoconstrictor acting by stimulation of the alpha-adrenergic receptors or the serotonergic receptors in the case of the cranial blood vessels?

    <p>Ergotamine</p> Signup and view all the answers

    What type of solution are alkaloids derived from lysergic acid sensitive to?

    <p>Aqueous solution</p> Signup and view all the answers

    Which structural analogy explains the affinity of ergot alkaloids and their derivatives for endogenous amine receptors and their ability to exert agonistic or antagonistic effects on those receptors?

    <p>Stereochemistry</p> Signup and view all the answers

    Which color reaction can be used for the quantitation of ergot alkaloids?

    <p>Red color</p> Signup and view all the answers

    Which method can be used for the analysis of complex alkaloid mixtures such as total alkaloids, fermentation media, and pharmaceutical formulations?

    <p>High-performance liquid chromatography (HPLC)</p> Signup and view all the answers

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