6 Questions
What is the normal range of alkaline phosphatase (ALP) for a 10-year-old?
107-213 IU/L
Which condition is associated with more than a threefold increase in serum alkaline phosphatase?
Extrahepatic obstruction
Which liver condition typically shows only slight increases in serum alkaline phosphatase?
Hepatitis
Why do children and adolescents have higher total alkaline phosphatase activity than adults?
Higher production of the bone isoform during growth
What situation in adults is associated with a higher total level of alkaline phosphatase?
Pregnancy
Which of the following conditions principally affects parenchymal cells and leads to moderately elevated serum alkaline phosphatase activity?
Hepatitis
Study Notes
Normal Range of Alkaline Phosphatase (ALP)
- 3 years: 71-142 IU/L
- 10 years: 107-213 IU/L
- Adult: 32-92 IU/L
Clinical Significance of ALP
- Higher ALP levels in children and adolescents due to increased bone isoform production during growth
- Higher ALP levels in pregnant women due to increased placental isoform production
Liver Diseases
Extrahepatic Obstruction
- ALP elevation is more marked (more than threefold) in cases such as stone or cancer of the head of pancreas
Hepatocellular Disorders
- Slight increases in ALP levels, usually less than three times upper limit of normal (ULN) in cases such as hepatitis and cirrhosis
- Liver diseases affecting parenchymal cells, such as hepatitis, typically have moderately elevated serum ALP activity
Learn about the normal range of alkaline phosphatase (ALP) in different age groups and its clinical significance in investigating hepatobiliary and bone diseases. Understand how ALP levels vary with age.
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