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What is the normal range of alkaline phosphatase (ALP) for a 10-year-old?
What is the normal range of alkaline phosphatase (ALP) for a 10-year-old?
- 95-200 IU/L
- 32-92 IU/L
- 107-213 IU/L (correct)
- 71-142 IU/L
Which condition is associated with more than a threefold increase in serum alkaline phosphatase?
Which condition is associated with more than a threefold increase in serum alkaline phosphatase?
- Cirrhosis
- Hepatitis
- Extrahepatic obstruction (correct)
- Fatty liver
Which liver condition typically shows only slight increases in serum alkaline phosphatase?
Which liver condition typically shows only slight increases in serum alkaline phosphatase?
- Hepatitis (correct)
- Pregnancy-related conditions
- Bone diseases
- Extrahepatic obstruction
Why do children and adolescents have higher total alkaline phosphatase activity than adults?
Why do children and adolescents have higher total alkaline phosphatase activity than adults?
What situation in adults is associated with a higher total level of alkaline phosphatase?
What situation in adults is associated with a higher total level of alkaline phosphatase?
Which of the following conditions principally affects parenchymal cells and leads to moderately elevated serum alkaline phosphatase activity?
Which of the following conditions principally affects parenchymal cells and leads to moderately elevated serum alkaline phosphatase activity?
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Study Notes
Normal Range of Alkaline Phosphatase (ALP)
- 3 years: 71-142 IU/L
- 10 years: 107-213 IU/L
- Adult: 32-92 IU/L
Clinical Significance of ALP
- Higher ALP levels in children and adolescents due to increased bone isoform production during growth
- Higher ALP levels in pregnant women due to increased placental isoform production
Liver Diseases
Extrahepatic Obstruction
- ALP elevation is more marked (more than threefold) in cases such as stone or cancer of the head of pancreas
Hepatocellular Disorders
- Slight increases in ALP levels, usually less than three times upper limit of normal (ULN) in cases such as hepatitis and cirrhosis
- Liver diseases affecting parenchymal cells, such as hepatitis, typically have moderately elevated serum ALP activity
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