Podcast
Questions and Answers
What is the major advantage of using osteocalcin as a marker?
What is the major advantage of using osteocalcin as a marker?
- It is elevated in pregnant women
- It follows a circadian rhythm
- It is a specific marker of liver disease
- It reflects expected changes in bone formation (correct)
Which tissues contribute to alkaline phosphatase activity in the body?
Which tissues contribute to alkaline phosphatase activity in the body?
- Osteoclasts and fibroblasts
- Osteoblasts and odontoblasts
- Adipocytes and muscle cells
- Liver, bone, and placenta (correct)
What is the main difference between bone and liver isoforms of alkaline phosphatase?
What is the main difference between bone and liver isoforms of alkaline phosphatase?
- Different molecular weights
- Different amino acid sequences
- Different colors under a microscope
- Different glycosylation patterns (correct)
When are the highest levels of osteocalcin observed during the menstrual cycle?
When are the highest levels of osteocalcin observed during the menstrual cycle?
Which cells synthesize osteocalcin in the body?
Which cells synthesize osteocalcin in the body?
What characterizes the circadian rhythm of osteocalcin levels?
What characterizes the circadian rhythm of osteocalcin levels?
What is a limitation associated with the use of osteocalcin as a bone turnover marker?
What is a limitation associated with the use of osteocalcin as a bone turnover marker?
Why is measuring P1NP preferred over P1CP as a marker of bone formation in osteoporosis?
Why is measuring P1NP preferred over P1CP as a marker of bone formation in osteoporosis?
Why is urinary calcium no longer commonly used to assess bone resorption?
Why is urinary calcium no longer commonly used to assess bone resorption?
What is the main component of bone tissue that reflects high values in morning samples?
What is the main component of bone tissue that reflects high values in morning samples?
Why was the collagen-derived assay using urinary hydroxyproline considered lacking specificity and sensitivity?
Why was the collagen-derived assay using urinary hydroxyproline considered lacking specificity and sensitivity?
Why is procollagen type I N-terminus considered a reliable marker of bone formation?
Why is procollagen type I N-terminus considered a reliable marker of bone formation?
