12 Questions
What is the major advantage of using osteocalcin as a marker?
It reflects expected changes in bone formation
Which tissues contribute to alkaline phosphatase activity in the body?
Liver, bone, and placenta
What is the main difference between bone and liver isoforms of alkaline phosphatase?
Different glycosylation patterns
When are the highest levels of osteocalcin observed during the menstrual cycle?
During the luteal phase
Which cells synthesize osteocalcin in the body?
Mature osteoblasts, odontoblasts, and hypertrophic chondrocytes
What characterizes the circadian rhythm of osteocalcin levels?
Highest levels after midnight
What is a limitation associated with the use of osteocalcin as a bone turnover marker?
It has a short half-life
Why is measuring P1NP preferred over P1CP as a marker of bone formation in osteoporosis?
P1NP is more stable
Why is urinary calcium no longer commonly used to assess bone resorption?
It is influenced by various factors
What is the main component of bone tissue that reflects high values in morning samples?
Bone mineral
Why was the collagen-derived assay using urinary hydroxyproline considered lacking specificity and sensitivity?
It was derived from various collagen sources
Why is procollagen type I N-terminus considered a reliable marker of bone formation?
It is more stable than C-terminal propeptides
Learn about the different isoforms and tissue distribution of alkaline phosphatase, with a focus on the bone and liver isoforms. Understand their glycosylation patterns and cross-activity according to studies with monoclonal antibodies.
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