Alkaline Phosphatase Isoforms and Tissue Distribution
12 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the major advantage of using osteocalcin as a marker?

  • It is elevated in pregnant women
  • It follows a circadian rhythm
  • It is a specific marker of liver disease
  • It reflects expected changes in bone formation (correct)
  • Which tissues contribute to alkaline phosphatase activity in the body?

  • Osteoclasts and fibroblasts
  • Osteoblasts and odontoblasts
  • Adipocytes and muscle cells
  • Liver, bone, and placenta (correct)
  • What is the main difference between bone and liver isoforms of alkaline phosphatase?

  • Different molecular weights
  • Different amino acid sequences
  • Different colors under a microscope
  • Different glycosylation patterns (correct)
  • When are the highest levels of osteocalcin observed during the menstrual cycle?

    <p>During the luteal phase</p> Signup and view all the answers

    Which cells synthesize osteocalcin in the body?

    <p>Mature osteoblasts, odontoblasts, and hypertrophic chondrocytes</p> Signup and view all the answers

    What characterizes the circadian rhythm of osteocalcin levels?

    <p>Highest levels after midnight</p> Signup and view all the answers

    What is a limitation associated with the use of osteocalcin as a bone turnover marker?

    <p>It has a short half-life</p> Signup and view all the answers

    Why is measuring P1NP preferred over P1CP as a marker of bone formation in osteoporosis?

    <p>P1NP is more stable</p> Signup and view all the answers

    Why is urinary calcium no longer commonly used to assess bone resorption?

    <p>It is influenced by various factors</p> Signup and view all the answers

    What is the main component of bone tissue that reflects high values in morning samples?

    <p>Bone mineral</p> Signup and view all the answers

    Why was the collagen-derived assay using urinary hydroxyproline considered lacking specificity and sensitivity?

    <p>It was derived from various collagen sources</p> Signup and view all the answers

    Why is procollagen type I N-terminus considered a reliable marker of bone formation?

    <p>It is more stable than C-terminal propeptides</p> Signup and view all the answers

    More Like This

    Alkaline Phosphatase Interferences and Methods
    10 questions
    Alkaline Phosphatase Activity Quiz
    10 questions
    Alkaline Phosphatase Assay Protocol
    16 questions

    Alkaline Phosphatase Assay Protocol

    MonumentalEvergreenForest3954 avatar
    MonumentalEvergreenForest3954
    Use Quizgecko on...
    Browser
    Browser