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Questions and Answers
What is the primary outcome of long-term potentiation (LTP)?
What is the primary outcome of long-term potentiation (LTP)?
- A reduced ability to form new memories.
- A stronger connection between neurons, facilitating communication. (correct)
- The immediate forgetting of recently learned information.
- A temporary decrease in synaptic strength.
In the context of memory and learningç ”ç©¶, why was the sea slug Aplysia particularly attractive to researchers like Eric Kandel?
In the context of memory and learningç ”ç©¶, why was the sea slug Aplysia particularly attractive to researchers like Eric Kandel?
- Its simple nervous system, consisting of relatively few neurons, made it easier to study. (correct)
- Its brain was easily accessible for invasive experimentation.
- Its complex nervous system closely mimics that of humans.
- Its ability to perform complex cognitive tasks rivaled that of primates.
According to Donald Hebb's postulate, what strengthens the connection between two neurons?
According to Donald Hebb's postulate, what strengthens the connection between two neurons?
- When the neurons fire together, making communication easier next time. (correct)
- When there is a decrease in neurotransmitter release.
- When there is a physical separation of the neurons.
- When one neuron consistently inhibits the other.
What role does the amygdala play in memory processing, especially as it relates to disrupting reconsolidation?
What role does the amygdala play in memory processing, especially as it relates to disrupting reconsolidation?
During the reconsolidation phase, memories can be vulnerable and subject to change. In the study involving students recalling the Boston Marathon bombing, what type of story interfered with the reconsolidation of their memories of the event?
During the reconsolidation phase, memories can be vulnerable and subject to change. In the study involving students recalling the Boston Marathon bombing, what type of story interfered with the reconsolidation of their memories of the event?
According to research on reconsolidation, when is a consolidated memory susceptible to disruption?
According to research on reconsolidation, when is a consolidated memory susceptible to disruption?
How does the act of recalling a memory and discussing it with others contribute to its consolidation?
How does the act of recalling a memory and discussing it with others contribute to its consolidation?
What is the relationship between sleep and memory consolidation?
What is the relationship between sleep and memory consolidation?
How does the concept of consolidation explain why individuals with retrograde amnesia can typically recall childhood memories but struggle with more recent events?
How does the concept of consolidation explain why individuals with retrograde amnesia can typically recall childhood memories but struggle with more recent events?
What is the significance of consolidation in the context of memory?
What is the significance of consolidation in the context of memory?
What immediate effect might a head injury have regarding memory consolidation, and how does this manifest in recall?
What immediate effect might a head injury have regarding memory consolidation, and how does this manifest in recall?
How does long-term storage (growth of new synapses) compare to short-term storage (enhanced neurotransmitter release) in the sea slug Aplysia?
How does long-term storage (growth of new synapses) compare to short-term storage (enhanced neurotransmitter release) in the sea slug Aplysia?
What was one of the insights gained from studies on the sea slug Aplysia concerning changes in synapses?
What was one of the insights gained from studies on the sea slug Aplysia concerning changes in synapses?
In the context of reconsolidation, what distinguishes the effect of a drug or an electrical shock given during memory retrieval compared to its effect when given a day after initial encoding?
In the context of reconsolidation, what distinguishes the effect of a drug or an electrical shock given during memory retrieval compared to its effect when given a day after initial encoding?
What is the implication of research findings showing that seemingly consolidated memories can become vulnerable to disruption when recalled, requiring them to be consolidated again?
What is the implication of research findings showing that seemingly consolidated memories can become vulnerable to disruption when recalled, requiring them to be consolidated again?
Flashcards
Long-Term Potentiation (LTP)
Long-Term Potentiation (LTP)
A process of synaptic strengthening through repeated communication across synapses between neurons, making further communication easier.
Donald Hebb
Donald Hebb
Canadian neuroscientist who famously stated, "Cells that fire together wire together".
Disrupting Reconsolidation
Disrupting Reconsolidation
The idea that disrupting reconsolidation could help to eliminate or modify painful memories
Reconsolidation
Reconsolidation
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Consolidation
Consolidation
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Study Notes
Algorithmic Game Theory
- Combines computer science, game theory, and economics.
- Focuses on designing and analyzing algorithms for strategic interactions and understanding strategic agent behavior in networked systems.
Selfish Routing
- Model involves a network of $n$ nodes and $m$ edges.
- Each edge $e$ has a cost function $\mathcal{l}_e(x)$, representing the cost (or delay) incurred by each traffic unit, with $\mathcal{l}_e(x)$ being non-negative, non-decreasing, and continuous.
- $k$ classes of users inject $r_i$ units of traffic from $s_i$ to $t_i$.
- A feasible flow $f$ ensures the traffic of each class is routed, with $\sum_{P:s_i \rightarrow t_i} f_p = r_i$ for every $i$.
- The total traffic on edge $e$ is defined as $f_e = \sum_{P:e \in P} f_p$.
- The cost incurred by traffic on edge $e$ is $f_e \cdot \mathcal{l}_e(f_e)$, with the total cost being $C(f) = \sum_e f_e \cdot \mathcal{l}_e(f_e)$.
- In a Nash equilibrium flow, no user can unilaterally switch paths to lower their cost, satisfying $\sum_{e \in P} \mathcal{l}_e(f_e) \le \sum_{e \in P'} \mathcal{l}_e(f_e)$ for every $s_i-t_i$ path $P'$ given $f_p > 0$.
Braess's Paradox
- Adding an edge to a network can increase the total cost at Nash equilibrium.
Price of Anarchy (PoA)
- Measures the inefficiency of Nash equilibrium.
- Defined as the ratio between the total cost at Nash equilibrium and the optimal total cost: $PoA = \frac{C(f)}{C(f^*)}$.
- $f$ is a Nash equilibrium flow and $f^*$ is an optimal flow.
- Price of Stability (PoS) is the ratio of the best Nash equilibrium cost to the optimal cost.
Mechanism Design
- A subfield of game theory designing games/mechanisms to achieve desired outcomes despite strategic player behavior.
- Also known as reverse game theory, starting with the intended outcome.
Elements of a Mechanism
- Consists of a set of agents, a type space (private information), an outcome space, and mechanism rules.
- Mechanism rules involve allocation rules (outcome determination) and payment rules (agent payments).
Single-Item Auction
- Agents are bidders with private item valuations (type space).
- Bidders win the item and pay a price (outcome space).
- Allocation rule dictates that the highest bidder secures the item.
- Payment methods include first-price (winner pays their bid) and second-price auctions (winner pays the second-highest bid).
Desirable Properties of Mechanisms
- Individual rationality where participation is beneficial to each agent.
- Truthfulness (incentive compatibility), so agents maximize their utility by revealing their true type.
- The goal is to maximize social welfare.
- Mechanisms may strive for budget balance.
- Computational efficiency is ideal.
Revelation Principle
- Any mechanism can be transformed into a direct mechanism where agents truthfully report their types.
- A direct mechanism is truthful if it's in each agent's best interest to report their actual type, regardless of others.
VCG Mechanism
- Guarantees truthfulness and social welfare maximization.
- Uses the principle that each agent pays the negative externality they impose on other agents (named after Vickrey, Clarke, and Groves).
Limitations of VCG
- Not always budget-balanced and can face computational challenges in certain contexts.
Coalitional Game Theory
- Studies of the behavior of coalitions of players.
- Focuses on how groups of players can cooperate to achieve a common goal and how benefits of cooperation should be divided among the players.
Key Concepts
- A coalition is a subset of players agreeing to cooperate.
- A characteristic function assigns a value to each coalition, representing its achievable total payoff.
- A solution concept specifies how payoffs should be distributed among players.
Cooperative vs. Non-Cooperative Game Theory
- Non-cooperative assumes independent, selfish players.
- Cooperative assumes players can form coalitions and make binding agreements.
Examples of Coalitional Games
- Voting games where players are voters and coalitions are majority groups.
- Cost-sharing games where players share costs.
- Matching games involving stable pairings.
Solution Concepts
- The Core represents stable payoff distributions with no coalition incentives to deviate.
- The Shapley Value offers a fair, efficient, and symmetric payoff distribution.
- The Nucleolus minimizes the maximum dissatisfaction of any coalition.
Applications of Coalitional Game Theory
- Applied in economics, political science, and computer science.
Social Choice Theory
- Studies collective decision-making and how individual preferences create a collective choice.
- Concerned with the properties of social choice rules and design.
Key Concepts
- Involves voters, alternatives, preference profiles, and social choice rules.
Examples of Social Choice Rules
- Majority rule, plurality rule, Borda count and Condorcet rule.
Desirable Properties of Social Choice Rules
- Pareto efficiency
- Condorcet winner criterion; independence of irrelevant alternatives (IIA).
- Non-dictatorship.
Arrow's Impossibility Theorem
- It is impossible to design a social choice rule that satisfies all of the desirable properties simultaneously.
- It highlights the fundamental difficulties of collective decision-making.
Gibbard-Satterthwaite Theorem
- Any social choice rule that is onto and non-dictatorial is manipulable.
- Manipulable describes that voters can obtain a better outcome by misrepresenting their preferences.
Applications of Social Choice Theory
- Important in designing voting systems and analyzing electoral outcomes.
- Helpful in the allocation of resources, and regulating markets.
- In computer science, used in designing recommendation systems.
Matrices
- A matrix is a rectangular array of real numbers, denoted by uppercase letters.
- Numbers inside the matrix are elements denoted by lowercase letters with subscripts for row and column. $$ A = \begin{bmatrix} a_{11} & a_{12} & \cdots & a_{1n} \ a_{21} & a_{22} & \cdots & a_{2n} \ \vdots & \vdots & \ddots & \vdots \ a_{m1} & a_{m2} & \cdots & a_{mn} \end{bmatrix} $$
Types of Matrices
- A square matrix has the same number of rows and columns ($m = n$).
- A diagonal matrix is a square matrix with all elements outside of the main diagonal being zero.
- An identity matrix is a diagonal matrix with all elements on the main diagonal equal to one, denoted by $I$.
Operations with Matrices
- Adding involves summing corresponding elements of two matrices, $A$ and $B$, of the same size.
- Scalar multiplication involves multiplying each element of matrix $A$ by a scalar $c$.
- Matrix multiplication is defined as the product of the of two matrices $A_{m \times n}$ and $B_{n \times p}$ resulting in a matrix $C_{m \times p}$.
Linear Equation Systems
- A set of linear equations with the same variables, representable in matrix form as $Ax = b$.
- $A$ is the coefficient matrix.
- $x$ is the variable vector.
- $b$ is the independent terms vector.
Solving Methods
- The solution of small systems employ substitution and elimination.
- The Gauss-Jordan method systematically transforms the augmented matrix $[A | b]$.
- Cramer's rule can finds the solution using determinants, provided the coefficient matrix is invertible.
Vector Spaces
- Vector spaces have set of objects or vectors.
- Two operations: vector addition and scalar multiplication are defined.
Subspaces
- A subset of a vector space also obeying vector space rules, under the same two operations.
Base and Dimension
- A basis of a vector space is a set of linearly independent vectors that span the entire space.
- The dimension is the number of vectors in a basis.
Linear Transformations
- Functions between vector spaces that preserve vector addition and scalar multiplication.
Matrix Representation
- Every linear transformation can be represented by a matrix like $[T]_\alpha^\beta$.
Kernel and Range
- The kernel of a transformation is the set of vectors that map to the zero vector.
- Range is the result of applying the transformation.
Eigenvalues and Eigenvectors
- Eigenvectors of a matrix $A$ ($v$) have the property $Av = \lambda v$.
- Where $\lambda$ are scalars called eigenvalues.
Calculating Eigenvalues
- Values are by solving the characteristic equation $\det(A - \lambda I) = 0$.
Diagonalization
- A matrix $A$ is diagonalizable if an invertible matrix $P$.
- The matrix $P^{-1}AP$ results in a diagonal matrix.
- The eigenvectors of $A$ the diagonal.
Finite Element Analysis Quick Start
- Import or create geometry
- Create a mesh
- Create a simulation
- Assign materials and conditions
- Run the simulation and post-process the results
Executive Summary
- Financial results of ALFA, S.A. for 2022.
- Methodology involved audited statements, and key ratios.
Financial Status
- Adequate liquidity
- Moderate debt
- Good solvency
Operational Performance
- Good profitability (NM:12%; ROE: 15%)
- Good asset efficiency
Cash Flow
- Good generating capacity, major investments.
Conclusions and Recommendations
- Good financial situation, maintain management quality.
The Ideal Op Amp Characteristics
- $R_{in} = \infty$
- $R_{out} = 0$
- $A = \infty$
- Golden rules:
- Inverting and non-inverting voltage amounts match
- No current flows.
Example: Non-Inverting Amplifier
- $V_{+} = V_{in}$
- $V_{+} = V_{-} = V_{in}$
- $V_{-} = V_{out} \frac{R_1}{R_1 + R_2}$
- $V_{in} = V_{out} \frac{R_1}{R_1 + R_2}$
- $A = \frac{V_{out}}{V_{in}} = \frac{R_1 + R_2}{R_1} = 1 + \frac{R_2}{R_1}$
Example: Inverting Amplifier
- $V_{+} = 0$
- $V_{+} = V_{-} = 0$
- $\frac{V_{in}}{R_1} + \frac{V_{out}}{R_2} = 0$
- $A = \frac{V_{out}}{V_{in}} = - \frac{R_2}{R_1}$
Vocabulary of Probabilities
- An experiment aléatoire is an experiment with results we know, but unpredictable, like rolling a die.
- L'univers of an experiment is the set of results, like $\Omega = {1, 2, 3, 4, 5, 6}$.
- Un événement is a subset of the univers, such as rolling even numbers ie. A = {2,4,6}.
- La probabilité d'un événement (P(A)) measures the likelihood between 0 and 1.
Vocabulary of Statistics
- Une population is the set of individuals studied, like students in a school.
- Un échantillon is a subset of the population.
- Un caractère is an object of study.
- Variable qualitative: When the object measured is immeasurable.
- example is a colour.
- Variable quantitative: When the object measured is measurable.
- Variable discrète: finite numbers. - example is a number of children or shoe size.
- Variable continue: full range on an interval. - is size and weight.
- L'effectif counts the occurrences .
- La fréquence counts the occurrences, in percentage
- Moyenne: The average of values.
- Médiane: A point separating half of each value -Etendue: The largest value minus the smallest value.
Introduction to Static Electricity
- Positive and negative charges exist that attract and repel each other.
- Electric Charge is conserved and quantized.
Conductors and Insulators
- Conductors allow free electron movement (e.g., copper, aluminum, silver).
- Insulators restrict electron movement (e.g., glass, rubber, wood).
Charging Objects
- Friction: Electrons transferred from rubbing
- Conduction: Electrons transferred from contact
- Induction: Charge redistribution without contact
Coulomb's Law
- Quantifies the electric force,
- $F = k \frac{|q_1 q_2|}{r^2}$.
Electric Field
- Electric field measures per unit charge.
Electric Potential Energy
- Electric potential energy is electrical force per charge unit.
Capacitance
- System stores charge via the the equation is expressed as with $C = \frac{Q}{V}$.
Intro to ANOVA
- ANOVA compares 2 or more population means. It is parametric, (data is normally distributed, variance is equal).
- ANOVA analyzed data from exp or obv studies.
Key Concepts
- A Factor is a variable that is used to group data. The independent variable.
- A factor level is a value of a factor.
- A treatment are combinations of factor levels.
- Response variable is continuous and measured for each subject.
- Response var is the dependent variable.
Hypotheses
- $H_0$ is when pop means are equal. $\mu_1 = \mu_2 = \dots = \mu_k$
- $H_0$ is satisfied. $H_1$ At least one , $\mu_i \neq \mu_j$
Assumptions
- Check the 1 Normality of data , 2 Homogeneity of Variance and 3 the Independence before proceeding with test.
One-Way ANOVA
- Tests only 1 factor
- Compares means
Partition of Variance
- Data breaks down to many forms
- $SST$ , or Total Sum of Squares =
- $SSTR$ or Sum of Squares Treatment
- $SSE$, or Sum of Squares Error
- ANOVA Identity: $SST = SSTR + SSE$.
Degrees of Freedom
- $DFT = N - 1$ (Total DOF)
- $DFTR = k - 1$ (Treatment DOF)
- $DFE = N - k$ (Error DF)
Mean Squares
- $MSTR = \frac{SSTR}{DFTR}$ (Treatment MS)
- $MSE = \frac{SSE}{DFE}$ (Error MS)
F-Statistic
- Statistic tests, based on equations from the mean squares.
- A large F-statistic signals something is wrong
ANOVA Table
- Has various sums, and the associated values with calculations to ensure that anova hypotheses stand
Decision Rule
- The hypothesis is invalid if P value is higher than alpha (fail to reject hypothesis), and valid vice versa.
Multiple Comparisons
- Null hypotheses are deemed false based on: - Bonferroni - Tukey's HSD (Honestly Significant Difference) - Fisher's LSD (Least Significant Difference)
Two Way AVONA
- Two factor presence.
- 2 hypotheses + 1 interaction hypothesis possible
Fraction Comparison Definitions
- Fraction: A whole is made up of fraction. Two key points: Numerator and Denominator.
Fraction Comparison Rules
To compare fractions, we compare directly or indirectly
- Fractions with the same denominator
- If equal denominators exist, largest numerator wins the comparison
- Fractions with the same Numerator - If equal numerators exist, smallest denominator wins the comparison
- Fractions Without equal numerator/denominators
- If unequal numerator/denominators exist, convert to make numerators/denominators match
- compare the fractions post conversion
- Comparing to 1
- A fraction is equal to 1, less than 1 or great than 1 based on numer/dem.
Summary Table
Method | Condition | How to do? |
---|---|---|
Direct Comparison | Same denominator | Compare numerators. |
Inverse Comparison | Same numerator | Compare denominators (smaller denominator = greater fraction). |
Common Denominator | Different denominators | Find common denominator, convert fractions, then compare numerators. |
Comparison to one or with 1 | Numerator and denominator | Use common sense, fraction is more, equal or less than 1. |
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