Podcast
Questions and Answers
Which vehicle was originally used to combine alfaxalone with alphadolone?
Which vehicle was originally used to combine alfaxalone with alphadolone?
- 2-hydroxypropyl-β-cyclodextrin
- Cyclodextran
- Cremophor EL
- Polyoxyethylated castor oil (correct)
Which formulation of alfaxalone was associated with histamine release and anaphylactic reactions in dogs?
Which formulation of alfaxalone was associated with histamine release and anaphylactic reactions in dogs?
- Cremophor EL® (correct)
- Saffan®
- Alfaxan‐CD®
- Althesin®
What is the chemical structure of alfaxalone?
What is the chemical structure of alfaxalone?
- Cremophor EL
- 3‐α‐hydroxy‐5‐α‐pregnane‐11,20‐dione (correct)
- 2‐hydroxypropyl‐β‐cyclodextrin
- Alphadolone
Which vehicle is used in the newer formulation Alfaxan‐CD®?
Which vehicle is used in the newer formulation Alfaxan‐CD®?
What type of species has the newer formulation of alfaxalone been approved for in several countries?
What type of species has the newer formulation of alfaxalone been approved for in several countries?
What should be done with any solution remaining in the vial of alfaxalone after withdrawal of the required dose?
What should be done with any solution remaining in the vial of alfaxalone after withdrawal of the required dose?
What respiratory effect was noted in cats receiving 50 mg/kg of alfaxalone?
What respiratory effect was noted in cats receiving 50 mg/kg of alfaxalone?
What effect on PaCO2 was observed in dogs receiving 6 and 20 mg/kg of alfaxalone?
What effect on PaCO2 was observed in dogs receiving 6 and 20 mg/kg of alfaxalone?
Which dogs did not experience apnea or increases in PaCO2?
Which dogs did not experience apnea or increases in PaCO2?
How does alfaxalone impact hepatic blood flow in Greyhounds?
How does alfaxalone impact hepatic blood flow in Greyhounds?
What enzyme is involved in the hepatic metabolism of alfaxalone?
What enzyme is involved in the hepatic metabolism of alfaxalone?
What is a possible source of pharmacokinetic differences between male and female animals when administered alfaxalone?
What is a possible source of pharmacokinetic differences between male and female animals when administered alfaxalone?
What is the mechanism of action by which alfaxalone produces CNS depression?
What is the mechanism of action by which alfaxalone produces CNS depression?
Which receptor does alfaxalone primarily act on to induce CNS depression?
Which receptor does alfaxalone primarily act on to induce CNS depression?
What effect does alfaxalone have on intracranial pressure?
What effect does alfaxalone have on intracranial pressure?
In terms of metabolism, what do cats and dogs have in common regarding alfaxalone?
In terms of metabolism, what do cats and dogs have in common regarding alfaxalone?
What is the mean terminal plasma elimination half‐life of alfaxalone in cats for a 5 mg/kg dose?
What is the mean terminal plasma elimination half‐life of alfaxalone in cats for a 5 mg/kg dose?
What is the primary route of elimination for alfaxalone metabolites?
What is the primary route of elimination for alfaxalone metabolites?
