Podcast
Questions and Answers
What is the generic name for Aldactone?
What is the generic name for Aldactone?
spironolactone
Which of the following are brand names for spironolactone? (Select all that apply)
Which of the following are brand names for spironolactone? (Select all that apply)
What is Aldactone indicated for?
What is Aldactone indicated for?
The treatment of heart failure, hypertension, edema, and primary hyperaldosteronism.
What type of drug is Aldactone?
What type of drug is Aldactone?
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Aldactone can cause tumors in animals.
Aldactone can cause tumors in animals.
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Which conditions should prevent you from using Aldactone? (Select all that apply)
Which conditions should prevent you from using Aldactone? (Select all that apply)
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What should be monitored in elderly patients taking Aldactone?
What should be monitored in elderly patients taking Aldactone?
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What is the risk associated with Aldactone in patients with renal impairment?
What is the risk associated with Aldactone in patients with renal impairment?
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In what circumstances should Aldactone be initiated in a hospital setting?
In what circumstances should Aldactone be initiated in a hospital setting?
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Study Notes
Generic Name
- Spironolactone (pronounced spir ON oh LAK tone)
Brand Names
- Available as Aldactone and CaroSpir
Indications and Usage
- Treats New York Heart Association (NYHA) Class III-IV heart failure with reduced ejection fraction.
- Acts to increase survival, manage edema, and decrease hospitalization for heart failure.
- Used as an add-on therapy for hypertension, aiding in lowering blood pressure to reduce cardiovascular risks.
- Manages edema in cirrhotic adults unresponsive to fluid and sodium restrictions.
- Treats nephrotic syndrome when other treatments are inadequate.
- Addresses primary hyperaldosteronism with short-term preoperative treatment and long-term maintenance.
Description
- Available in oral tablets with dosages of 25 mg, 50 mg, and 100 mg.
- Contains spironolactone, which is nearly insoluble in water but soluble in alcohol and easily soluble in benzene and chloroform.
- Inactive ingredients include calcium sulfate, corn starch, and magnesium stearate.
Geriatric Use
- Excretion primarily via kidneys; risk of adverse reactions is heightened in the elderly with renal impairment.
- Regular monitoring of renal function is advised.
Use in Renal Impairment
- Increased risk of hyperkalemia in patients with renal impairment.
- Close monitoring of potassium levels is necessary.
Use in Hepatic Impairment
- May cause fluid and electrolyte balance issues, leading to worsened neurological function in patients with liver disease.
- Initiate treatment in a hospital setting for patients with hepatic conditions.
Classifications
- Potassium-sparing diuretic effective for hypertension and edema.
- Functions as an aldosterone antagonist.
Important Information
- Contraindicated for individuals with kidney issues, high potassium levels, Addison's disease, inability to urinate, or concurrent use of eplerenone.
- Potential tumorigenic effects observed in animal studies; unknown if it applies to humans.
- Usage only as prescribed by a healthcare provider for verified conditions.
Precautions Before Use
- Not advised for patients allergic to spironolactone or with Addison's disease, hyperkalemia, or inability to urinate.
- Health history review should include renal, liver, electrolyte imbalances, or heart diseases.
- Unknown effects of the drug on pregnancy; consult a doctor if pregnant or planning to conceive.
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Description
Test your knowledge on Aldactone, its generic name spironolactone, and brand names. These flashcards cover its indications and usage, particularly in heart failure treatment. Perfect for medical students or healthcare professionals looking to refresh their understanding of this important medication.
