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Questions and Answers
What does pharmacokinetics study in the body?
What does pharmacodynamics study in the body?
What happens to lipid-soluble drugs when they enter the body?
Why are drugs metabolized?
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What is an important factor in the pharmacological effects of a drug?
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What is the abbreviation for the process of drug movement through the body?
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What is the relationship between pharmacodynamics and pharmacokinetics?
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What is a result of leaky plasma membranes in damaged liver cells?
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What percentage of the total amount of drug in the body is typically excreted in an unchanged state?
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What is hyperbilirubinaemia a result of?
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What is the primary purpose of drug metabolism?
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In which phase of metabolism is a reactive group exposed or added to the parent molecule?
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What is a result of decreased albumin synthesis in the liver?
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What is the most common conjugate used in phase II metabolism?
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What is a result of reduced lipoprotein synthesis in the liver?
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What is a consequence of excessive alcohol consumption?
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What is the high-energy cofactor required for phase I metabolism?
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What is the purpose of conjugation in phase II metabolism?
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Which enzyme is used as a diagnostic indicator of liver cell damage?
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What type of enzyme system is required for phase I metabolism?
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What is the major site of lipogenesis?
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What is a common effect of high concentrations of alcohol on the GI cells?
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Which of the following nutrients is impaired in its absorption due to high alcohol consumption?
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What is a neurological symptom associated with thiamine deficiency?
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What is the name of the syndrome that can result from thiamine deficiency?
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What is the role of Disulfiram in the treatment of chronic alcohol dependence?
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What is the effect of Disulfiram on the patient if they drink alcohol?
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What is required for Disulfiram to be effective in treating alcohol dependence?
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What happens to liver cells when NADH levels increase?
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What is the result of decreased lactate utilization by liver cells?
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Why is gluconeogenesis inhibited in the liver?
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What is a potential consequence of decreased gluconeogenesis in the liver?
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What contributes to the development of hypoglycaemia in alcoholics?
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What is acetaldehyde?
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What is the function of aldehyde dehydrogenase?
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What is the effect of increased acetyl-CoA availability on liver metabolism?
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What is the result of impaired liver function in alcoholics?
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