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Questions and Answers
Which of the following is an indication for Aggrastat?
Which of the following is an indication for Aggrastat?
- Treating unstable angina (correct)
- Treating stable angina
- Preventing headaches
- Treating stomach ulcers
Aggrastat can be used in patients who have had a stroke in the past 30 days.
Aggrastat can be used in patients who have had a stroke in the past 30 days.
False (B)
What is the mechanism of action of Aggrastat?
What is the mechanism of action of Aggrastat?
It inhibits platelet aggregation.
What are the trade and generic names for Aggrastat?
What are the trade and generic names for Aggrastat?
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The recommended dosage of Aggrastat is intravenously _____ mcg/kg IV infused within 5 min.
The recommended dosage of Aggrastat is intravenously _____ mcg/kg IV infused within 5 min.
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How is Aggrastat administered?
How is Aggrastat administered?
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Match the following adverse reactions with Aggrastat:
Match the following adverse reactions with Aggrastat:
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What is the drug classification of Aggrastat?
What is the drug classification of Aggrastat?
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Study Notes
Indications
- Utilized for treating unstable angina and specific types of heart attacks.
- Commonly administered alongside heparin for enhanced therapeutic effect.
Contraindications
- Not suitable for individuals with a history of stroke, bleeding complications, or major surgery within the past 30 days.
- Avoid use in patients with aneurysms, bleeding or clotting disorders, brain tumors, aortic tears, severe hypertension, or those on similar medications.
- Previous clotting issues from Aggrastat also contraindicate its use.
Mechanism of Actions
- Functions as a blood thinner by inhibiting platelet aggregation.
- Efficacy is dose and concentration-dependent.
Both Trade and Generic Name
- Trade name: Aggrastat
- Generic name: tirofiban
Dosage
- Initial dosage: 25 mcg/kg IV infusion within 5 minutes.
- Maintenance: 0.15 mcg/kg/min IV infusion for up to 18 hours.
- Adjust dosage to 0.075 mcg/kg/min IV if creatinine levels are less than 60, after the first 5 minutes.
Administration
- Administered via intravenous (IV) route.
Adverse Reactions and Side Effects
- Potential side effects include bleeding, pelvic pain, coronary artery dissection, dizziness, lower extremity pain, edema, sweating, and thrombocytopenia (low platelet count).
Drug Classification
- Classified as an antiplatelet agent, specifically a glycoprotein IIb/IIIa inhibitor.
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