Agents Inhibiting RNA Synthesis Quiz
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Questions and Answers

Which bacterial RNA synthesis inhibitor specifically interferes with the β subunit of the RNA polymerase?

  • Ciprofloxacin
  • Doxycycline
  • Rifampicin (correct)
  • Amoxicillin

What is the primary mechanism of action of agents that inhibit the 30S ribosomal subunit in bacteria?

  • Interfering with folic acid synthesis
  • Preventing DNA replication
  • Promoting cell division
  • Interfering with the initiation process of protein synthesis (correct)

Which antibiotic interferes with folic acid metabolism as a mechanism to inhibit the survival of microorganisms?

  • Vancomycin
  • Erythromycin
  • Trimethoprim (correct)
  • Penicillin

What type of resistance is acquired due to constant exposure to antimicrobial drugs over time?

<p>Acquired resistance (A)</p> Signup and view all the answers

How does the acquisition of resistance through transformation occur in bacteria?

<p>Insertion of foreign DNA into the DNA of the same species (B)</p> Signup and view all the answers

What is the main mechanism of action of β-lactam antibiotics like penicillins and cephalosporins?

<p>Inhibition of cell wall synthesis (C)</p> Signup and view all the answers

Which class of antibiotics is known to be cationic and includes polymyxin B and colistimethate?

<p>Aminoglycosides (B)</p> Signup and view all the answers

Which enzyme essential for DNA synthesis do agents inhibiting DNA topoisomerases target?

<p>DNA gyrase (C)</p> Signup and view all the answers

What is the main effect of aminoglycosides on ribosomes in protein synthesis?

<p>Causing formation of non-functional complexes (B)</p> Signup and view all the answers

Which bacterial ribosomal subunit is targeted by tetracycline antibiotics?

<p>30S ribosomal subunit (C)</p> Signup and view all the answers

Chloramphenicol, macrolides, and lincosamides are known to inhibit which specific process in protein synthesis?

<p>Elongation of translation (C)</p> Signup and view all the answers

What is transferred through the sex pilus during conjugation?

<p>Plasmid (D)</p> Signup and view all the answers

How do Gram-negative bacteria prevent antibiotics from reaching their cellular target?

<p>By changing the lipid composition of their outer membrane (C)</p> Signup and view all the answers

Which mechanism of antimicrobial resistance involves bacteria producing proteins structurally similar to antibiotic target sites?

<p>Target mimicry (C)</p> Signup and view all the answers

How does drug modification or inactivation lead to antibiotic resistance?

<p>By altering the chemical structure of antibiotics through enzymes (C)</p> Signup and view all the answers

Which type of antibiotic resistance mechanism involves alterations in the structure of target sites?

<p>Modification of target sites (A)</p> Signup and view all the answers

In antibiotic resistance, what does overproduction or bypass of target enzyme allow the organism to do?

<p>Continue essential enzymatic reactions despite antibiotics (C)</p> Signup and view all the answers

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