Ageing, Alzheimer's, MS & Parkinson's Disease

• The lecture covers ageing, Alzheimer's disease, multiple sclerosis (MS), and Parkinson's disease.

Main Theories Behind the Causes of Aging

• Main theories and causes of ageing are explored
• How the body defends itself against ageing
• How a little stress, known as hormesis, increases lifespan and 'healthspan'
• Inflammageing is chronic low-grade inflammation which increases with age
• Inflammageing leads to many age-related diseases
• Pathogens, damaged tissues, altered gut microbiota, antibiotics, steroids, and antihistamines all promote chronic inflammation
• Allostatic load is the "overload theory" which details social, psychological, lifestyle, and nutritional factors interacting with genetics to influence healthy ageing or accelerated decline
• Exposure to toxins, inadequate exercise, poor nutrition, high stress, genetic susceptibility, chronic inflammation and dysbiosis all play a role at a physiological and molecular level.
• Mitochondria are the main source of ROS in a cell according to Mitochondrial theory
• Oxidative stress within mitochondria leads to mtDNA mutations, reduced ATP and energy.
• Mitochondria dysfunction leads to apoptosis (programmed cell death).
• Mitochondrial dysfunction is also linked to MS, Alzheimer's, Parkinson's and many chronic inflammatory conditions

Maximum Lifespan Potential

• Ageing is mostly considered a negative but, in general, humans are exceptionally good at dealing with the processes
• Humans have a maximum lifespan potential(MLSP) of over 100 years which is four times higher than expected for mammals of our size!
• Anti-ageing strategies will improve 'healthspan' as well as lifespan

Hormesis

• The definition of hormesis is "A process in which exposure to a low level of stress or toxicity induces an adaptive beneficial effect in a cell or organism".
• Calorie restriction, phytochemicals, exercise, cognitive stimulation, intermittent cold and heat mildly stress the body and they can all extend lifespan and healthspan.
• A healthy body responds to mild stress by increasing the production of endogenous antioxidants and cellular quality control mechanisms.
• This results in an increased production of glutathione, catalase, superoxide dismutase and phase II detoxification enzymes.
• Nrf2 is a transcription factor which senses cellular stress and then upregulates genes related to antioxidant production
• Nrf2 attaches to the ARE within DNA and increases the expression of glutathione enzymes, superoxide dismutase, catalase and phase II detoxification enzymes
• Long-lived species such as humans have an increased activity of Nrf2.
• The anti-oxidant power of phytochemicals can be direct, through direct antioxidants, and indirect through mild stresses that engage Nrf2
• Calorie restriction and exercise induce stress partly by depleting cellular energy, ATP and NADH but increasing ADP and NAD.
• As a result, low cellular energy activates AMPK, a pro-longevity protein, and sirtuins (SIRT 1-7), a family of the anti-ageing proteins.

Quality Control and Longevity

• AMPK and Sirtuins initiate processes that improves health and prolong live
• This occurs at tissue, cellular, and molecular level
• During a period of low cellular energy, AMPK and Sirtuins initiate autophagy (self-eating) where worn-out elements of the cell are digested
• Autophagy of mitochondria is mitophagy.
• Healthy cells undergo mitophagy every few days
• The mitochondria are digested between 9-25 days after being birthed
• Liver mitochondria turnover more rapidly than brain, heart and kidney mitochondria
• Defective Mitophagy is linked to Alzheimer's and Parkinsons with Alzheimer's showing low brain energy
• Autophagy defends against 9 key signatures of ageing including: Genome instability, Telomere shortening, Epigenetic alterations, Loss of protein regulation and disposal — hallmark of Alzheimer's/Parkinsons, insulin resistance and poor nutrient sensing, Cell senescence (biological ageing), Stem cell loss, and Altered cell communication

Social Connection and Detoxification Impact Ageing

• Social connection impacts health
• Social connection is most important for the elderly and children
• Poor childhood social connectedness or trauma predisposes to inflammatory diseases in later life
• Social connectedness in the elderly works as a anti-inflammatory with similar powerful results as smoking cessation or exercise
• BMI, blood pressure and inflammation can all be reduced as a result, while social stress triggers the exact opposite effect.
• Phase I detoxification enzymes transform Xenobiotics, steroid hormones, and drugs into reactive intermediates via additional oxygen
• Hydrocarbons from cooking foods or smoke are common xenobiotics
• Phase I detoxification enzymes are mostly found in the liver but also in the kidneys, gut and brain
• AhR receptor detects xenobiotics driving gene expression of phase 1 enzymes
• Over stimulation of AhR leads to accelerated ageing, cardiovascular disease, cancer, and inflammation
• Green tea, turmeric, quercetin, and Resveratrol slow down Phase 1 and defend against cancer
• Garlic and Ginger are thought to share similar affects
• Neanderthals had 100-1000 times more hydrocarbon detoxification which made fire and invention food lethal
• Hormesis supports Phase II and III
• Via Nrf2 anti-ageing Phase II/III will activate plant compounds
• Phase II conjugations link to phase 1 intermediates
• Phase III, Removes Detoxified Metabolites out of cells Nrf2 upregulation plus Phase II neuroprotective in those who have Parkinson's and Alzheimer's

Benefits Of Exercise and Proper Dieting

• Regular exercise can help manage hallmarks of ageing and improve function for the body, brain and metabolic functions
• Through Nrf2 and hormesis it promotes antioxidant production
• Supports production of PGC1 for synthesis of new mitochondria within biogenesis process
• World's longest lived people live on Island of Okinawa and have highest concentrations of centenarians around the world eating unrefined carbs and a light intake of fish
• Only eating ~80%
• Intermittent fasting and calorie restriction help with longevity
• Sirtuins are activated which supports insulin and healthy cardiac function
• Promotes rejuvenation of cell with autophagy, which is tied with adiponectin that has an aging benefit
• Those doing keto retain benefits thanks to beta-oxidation, while ketones preserve healthy brain aging
• Insulin resistant, obese, present with Mitochondrial dysfunction, low viable stem cells and more inflammation which is an advanced glycation effect

Important Things To Avoid

• Toxins
• Inadequate exercise
• Poor nutrition
• High stress
• Dysbiosis of microbiome
• Medication, especially over-the-counter drugs
• Antibiotics
• Alcohol and smoking
• Coffee, sugars
• B vitamins,
• Omega 3,
• Alpha-Lipoc acid,
• Green tea,
• berries,
• cruciferous vegetables,
• and nuts

Dementia and Alzheimer's Disease

• Describes a syndrome of cognitive impairment that affects memory recall and significantly interferes with a person's ability to perform daily activities. Alzheimer
• the most common accounts 60-80 plus % of dementia
• 50,000,000 across the globe suffer from the disease
• Almost 10 million are impacted each year with 60% in world's poorest

Risk Factors For these Diseases

• Chronic / acute stress
• Proton pump inhibitor medication
• Poor diet (junk food, sugars)
• Vitamin and nutritional deficiencies E.G, A, D, C, B6, B9, B12 ETC.
• Poor lifestyle E.G, Alcohol plus smoking
• Vaccinations ApoE (Apolipoprotein E)
• Mental plus physical inactivity
• Environmental toxins
• Obesity plus Midlife depression

The 4 Types Common of Dementia

• Frontotemporal language/movement difficulties
• Vascular; Cognitive declines with impaired flow, and cardiac disease
• Lewy body dementia Lewy bodies impact thoughts
• Alzheimer's beta amyloid/TAU

What Is Critical To Understand About Alzheimer's Disease

• Plaque and tangles, not the causes or symptoms but oxidative stress
• It is a protection element as opposed to a threat

Brain Health and Alzheimer's Solutions

• Online headquarters for brain training - https://www.brainhq.com/
• The most critical point? Scan with MRI, CT, PET
• Bredesen said three forms are hot
• (Inflammation) cold BDNF deficit from tropics
• Toxic- the brain
• Microglia - M1 + M2, polarized and help the brain, inflammation
• Pathogens cause the loss of cells and damage

Growing New Neurons For Improved Brain Health

• The hippocampus is key
• 70k new neurons are created only survive if inflammation is low
• Depression may grow the risk of inflammation
• gut microbe health can support
• BDNF has a huge function which allows Yoga and aerobic exercise that supports synapses
• Choline is most essential for supporting the release of nutrients, integrity and a sane community.
• Aluminum chelation using cilatro or Fiji based water
• Aluminum can cause Alzheimer's
• There is such a thing called Type 3 which refers to diabetes of the brain
• Increase is linked and triggered
• Sympathetic overdrive plus low acetylcholine
• Healthy, the overdrive helps trigger more brain function that can drop such disease by promoting
• Brain is 80 percent water

Good Recommendations To Follow and Support Brain Health

• Advice
• Unprocessed diet
• GI Kale, Broccoli, cauliflower
• Healthy fats/ olive + omega and fatty fish with pasture fed produce and drink water Ketoflex has hours and helps support with the mildness which is beneficial
• MIND supports with good omega and leafy green as well
• Boost ketones
• coconut oil can help the function thanks to medium triglycerides

Common Supplements and Tools To Use For Type 3 Diabetes

• MEND approach can promote high value for brain and liver support
• Exercise, reduce stress, and the test of C Reactive
• Vitamin b and Repair
• MEND2 + the diet can boost the function as a result
• There can be negative effects such as side affect and intolerance with Alzheimer such ad nausea
• Drugs like beta help

MS (Multiple Sclerosis)

• an auto immune illness which damages myelin of the protein. As a resuly, MS is an Autoreactive cells infiltration 85% present and have the disease ( relapsing/myelin loss) avg 30
• 10-15 have function low avg 45
• Symptoms affect visual from optic nerve to cause tingle, bladder fatigue, lack coordination balance along speech and memory
• It is more likely to develop around the secondary stage for female which leads to quick progression as symptom
• Vitamin Def increase with a shift to higher reactions of regulatory cells
• Deficiency often raised levels of BM
• trauma stress
• High homocysteine and other deficiencies, this includes environmental toxicity

Support with

• vitamin therapy and help shift function to regulatory cells
• Vitamin Def with decreased relapse
• Those with low D has huge numbers
• A good diet helps the body with support toward vitamin production
• The Def of Vitamin K is very prevalent
• Regernates cells
• 6 can protect these cells that have low blood levels around 1/3
• Caused by little and low intake

Ways to Supplement

Studies show that improved nerve sheaths include Vitamin B12 Deficiency with high levels of all that it can affect the cell Many are low B12, this helps the cells stay proper with low amounts plus the fats

Factors Affecting MS (Obesity, Stress and Poor Diet)

• High BM can cause an early onset to high instability
• Childhood with high rate of a poor barrier to the brain can lead to inflammation
• Leptin can lead to issues with autoimmune to CNS inflammation Stress Sympathetic overdrive plus the vagus effects the connections which lead of high overdrive and less performance Vagal Stimulation can increase anti-inflammatory
• The use can greatly improve function Can Support
• Vitamin D at 2000 UI
• K at 90
• hes/ quercetin
• Sulfo
• Citicolline
• Omega All as an effort to support and work at cellular level to prevent further disruption

Supporting Ms With Diet The Swank

• Low amounts with sat fats should never push over 15
• Poor body has issues with absorbing at this level
• There be a ton of fruits plus veggies with high consumption avoid the 1st year of pork as a restriction
• Whites as a option around low g range

Dr Terry Wahls is in ms remission after following a paleo diet:

• Green leafy vegetables, * Sulphur-rich vegetables, such as cabbage, onions and asparagus. + Colourful fruits and vegetables due to their phytonutrient content, such as beetroot, oranges, berries and carrots.
• Omega-3 fatty acids Sources:
• Salmon, herring, and sardines.
• Grass-fed meats and organ meats. * Seaweed. Dr Wahls’ diet is less strict on saturated fat intake. However grass- fed meats are lower in saturated fat than intensively farmed animals Parkinsons
• 2nd most common after Alzheimer's relating to neurons -gradual lack of dopamine can trigger major loss in a certain part
• Neuron supply of the Nigra can lead to striatum -decline leads to tremors and disorder
• Common signs
• Hand tremors
• Poor Muscle
• poor Shuffle
• Low Constipation
• Slow writing or speech Causes can be
• Heritary
• Poor Mitochondrial fuction
• injury
• Toxins
• Low Calcium intake

Best test to find in such case would be

• Data Scan
• Pat scan which identifies those traits Related with Synuclenin Similar protein
• Aggregates known as lewy
• Oxidation + mitocondrical breakdown Can Be
• Mang
• Iron
• Mercury -Aluminum

Natural Remedies

• Rotenone
• paraquat Maneb
• May assist but use in short amounts to prevent the damage due to the effects on dopamine plus the serotonin cells can get impacted -dopa

Catechol theory

• MAOB that converts do toxic and elevated levels That increase stress and the misfolded the brain which is why antioxidants are needed. Support by speeding up such detox and that which is Dopamine into The body and with help from berrys

Early sign low is signs and Constipation and the build up into the gut to brain connection

• brain diet is helpful
• mend and protocols

Treatment & Advice

• HBOT and minimize devices
• chelate with cilantro as well as minimize dairy plus gluten
• Perlmutter that diet of green leafy vegetables, beans Brodosein diet with help of high ketone high and some key remedies can help
• MEND has a range of methods and some common remedies that improve a huge chance, support and prevent a negative outcome, such as alpha, omega and K

This lecture explores the causes of aging, including theories on how the body defends itself. It covers inflammageing, chronic low-grade inflammation, and allostatic load, detailing social, psychological, lifestyle, and nutritional factors influencing healthy aging. The lecture also touches on Alzheimer's, multiple sclerosis (MS), and Parkinson's disease.