Adverse Reactions to Melarsoprol and Antischistosomal Agents Quiz
18 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What was a significant limitation of the early use of antimonials as schistosomicides?

  • High cost
  • Toxicity (correct)
  • Short treatment courses
  • Lack of availability

    • Which group discovered Niridazole and in what year?

  • Smith & Smithson, 1980
  • Johnson & Johnson, 1972
  • Lambert & co-workers, 1964 (correct)
  • Baker & team, 1968

    • What is the impact of Niridazole on carbohydrate metabolism in schistosomes?

  • Reduces glycogen breakdown
  • Speeds up the breakdown of glycogen (correct)
  • Halts glycogen synthesis
  • Increases glycogen storage

    • Why is Niridazole contraindicated in pregnancy?

    <p>Can cause teratogenic effects</p> Signup and view all the answers

    What makes Praziquantel a breakthrough in antischistosomal treatment?

    <p>Safety, efficacy, and broad spectrum activity</p> Signup and view all the answers

    Which group of schistosomes is effectively targeted by Praziquantel?

    <p><em>Schistosoma</em> species affecting humans</p> Signup and view all the answers

    What is the vector for Trypanosoma cruzi, the parasite that causes Chagas disease?

    <p>Sandfly</p> Signup and view all the answers

    Which of the following symptoms is NOT associated with Trypanosoma infection?

    <p>Cough</p> Signup and view all the answers

    Which class of drugs includes melarsoprol, a medication commonly used against African trypanosomiasis?

    <p>Organic arsenicals</p> Signup and view all the answers

    How is Trypanosoma infection typically transmitted to humans?

    <p>Through a tsetse fly bite</p> Signup and view all the answers

    Which form of African sleeping sickness is caused by Trypanosoma gambiense?

    <p>Central and Western African form</p> Signup and view all the answers

    What is the primary target of drugs like pentamidine used in the treatment of Trypanosoma infections?

    <p>Parasite's nervous system</p> Signup and view all the answers

    What is the main reason why melarsoprol's application as a trypanocidal agent is limited?

    <p>High toxicity causing potentially fatal reactive encephalopathy</p> Signup and view all the answers

    Which of the following is NOT one of the three major species of Schistosoma that infect humans?

    <p>Schistosoma cardiaca</p> Signup and view all the answers

    What is the main route of infection for Schistosoma parasites in humans?

    <p>Penetration through the skin</p> Signup and view all the answers

    What is an important measure for host and vector control in combating Schistosomiasis?

    <p>Provision of clean water supply</p> Signup and view all the answers

    What are the qualities of an ideal anti-schistosomal agent mentioned in the text?

    <p>Absence of side effects and toxicity in humans</p> Signup and view all the answers

    Which of the following is NOT an example of a molluscicide used against the snail host of Schistosoma parasites?

    <p>Diethylcarbamazine</p> Signup and view all the answers

    Use Quizgecko on...
    Browser
    Open
    Browser
    Browser