Adverse Reactions to Melarsoprol and Antischistosomal Agents Quiz
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Questions and Answers

What was a significant limitation of the early use of antimonials as schistosomicides?

  • High cost
  • Toxicity (correct)
  • Short treatment courses
  • Lack of availability

Which group discovered Niridazole and in what year?

  • Smith & Smithson, 1980
  • Johnson & Johnson, 1972
  • Lambert & co-workers, 1964 (correct)
  • Baker & team, 1968

What is the impact of Niridazole on carbohydrate metabolism in schistosomes?

  • Reduces glycogen breakdown
  • Speeds up the breakdown of glycogen (correct)
  • Halts glycogen synthesis
  • Increases glycogen storage

Why is Niridazole contraindicated in pregnancy?

<p>Can cause teratogenic effects (B)</p> Signup and view all the answers

What makes Praziquantel a breakthrough in antischistosomal treatment?

<p>Safety, efficacy, and broad spectrum activity (D)</p> Signup and view all the answers

Which group of schistosomes is effectively targeted by Praziquantel?

<p><em>Schistosoma</em> species affecting humans (A)</p> Signup and view all the answers

What is the vector for Trypanosoma cruzi, the parasite that causes Chagas disease?

<p>Sandfly (A)</p> Signup and view all the answers

Which of the following symptoms is NOT associated with Trypanosoma infection?

<p>Cough (D)</p> Signup and view all the answers

Which class of drugs includes melarsoprol, a medication commonly used against African trypanosomiasis?

<p>Organic arsenicals (A)</p> Signup and view all the answers

How is Trypanosoma infection typically transmitted to humans?

<p>Through a tsetse fly bite (D)</p> Signup and view all the answers

Which form of African sleeping sickness is caused by Trypanosoma gambiense?

<p>Central and Western African form (A)</p> Signup and view all the answers

What is the primary target of drugs like pentamidine used in the treatment of Trypanosoma infections?

<p>Parasite's nervous system (A)</p> Signup and view all the answers

What is the main reason why melarsoprol's application as a trypanocidal agent is limited?

<p>High toxicity causing potentially fatal reactive encephalopathy (D)</p> Signup and view all the answers

Which of the following is NOT one of the three major species of Schistosoma that infect humans?

<p>Schistosoma cardiaca (A)</p> Signup and view all the answers

What is the main route of infection for Schistosoma parasites in humans?

<p>Penetration through the skin (B)</p> Signup and view all the answers

What is an important measure for host and vector control in combating Schistosomiasis?

<p>Provision of clean water supply (D)</p> Signup and view all the answers

What are the qualities of an ideal anti-schistosomal agent mentioned in the text?

<p>Absence of side effects and toxicity in humans (C)</p> Signup and view all the answers

Which of the following is NOT an example of a molluscicide used against the snail host of Schistosoma parasites?

<p>Diethylcarbamazine (B)</p> Signup and view all the answers
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