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Questions and Answers
Which symptom may occur when a dopamine agonist is introduced and can be minimized by taking the medication with meals?
Which symptom may occur when a dopamine agonist is introduced and can be minimized by taking the medication with meals?
- Peripheral edema
- Constipation
- Postural hypotension
- Anorexia (correct)
What is an indication for discontinuing treatment with dopamine agonists?
What is an indication for discontinuing treatment with dopamine agonists?
- Cardiac arrhythmias (correct)
- Bleeding from peptic ulceration
- Peripheral edema
- Constipation
Which symptom of Parkinson's disease or dopaminergic treatment is more common and severe with dopamine receptor agonists than with levodopa?
Which symptom of Parkinson's disease or dopaminergic treatment is more common and severe with dopamine receptor agonists than with levodopa?
- Peripheral edema
- Postural hypotension
- Dyskinesias
- Psychiatric reactions (correct)
What may lead to compulsive gambling, shopping, betting, and sexual activity in patients on dopamine agonists?
What may lead to compulsive gambling, shopping, betting, and sexual activity in patients on dopamine agonists?
Which side effect is NOT associated with Amantadine use?
Which side effect is NOT associated with Amantadine use?
Which adverse effect is typical of Acetylcholine-Blocking drugs?
Which adverse effect is typical of Acetylcholine-Blocking drugs?
Which medication provides temporary relief of off-periods of akinesia in Parkinson's patients?
Which medication provides temporary relief of off-periods of akinesia in Parkinson's patients?
Which adverse effect of Levodopa can be minimized by taking the drug in divided doses, with or immediately after meals, and by increasing the total daily dose very slowly?
Which adverse effect of Levodopa can be minimized by taking the drug in divided doses, with or immediately after meals, and by increasing the total daily dose very slowly?
What is a common side effect of Amantadine that responds to diuretics?
What is a common side effect of Amantadine that responds to diuretics?
What percentage of patients may experience postural hypotension, especially in the early stage of treatment with Levodopa?
What percentage of patients may experience postural hypotension, especially in the early stage of treatment with Levodopa?
Patients receiving Levodopa may experience a wide variety of side effects. Which cardiac arrhythmia has been described in some patients?
Patients receiving Levodopa may experience a wide variety of side effects. Which cardiac arrhythmia has been described in some patients?
What type of dyskinesias occur in up to 80% of patients taking Levodopa?
What type of dyskinesias occur in up to 80% of patients taking Levodopa?
What is dopamine dysregulation syndrome characterized by?
What is dopamine dysregulation syndrome characterized by?
Why should Levodopa not be given to patients taking monoamine oxidase A inhibitors or within 2 weeks of their discontinuance?
Why should Levodopa not be given to patients taking monoamine oxidase A inhibitors or within 2 weeks of their discontinuance?
What is Punding as described in the text?
What is Punding as described in the text?
How do pharmacologic doses of pyridoxine (vitamin B6) affect the metabolism of levodopa?
How do pharmacologic doses of pyridoxine (vitamin B6) affect the metabolism of levodopa?
What is the mechanism through which reserpine causes parkinsonian symptoms?
What is the mechanism through which reserpine causes parkinsonian symptoms?
Which drug causes irreversible parkinsonism through destruction of dopaminergic neurons in the nigrostriatal tract?
Which drug causes irreversible parkinsonism through destruction of dopaminergic neurons in the nigrostriatal tract?
How do type B monoamine oxidase inhibitors (MAOIs) protect against MPTP neurotoxicity in animals?
How do type B monoamine oxidase inhibitors (MAOIs) protect against MPTP neurotoxicity in animals?
Why does dopamine not have a therapeutic effect in parkinsonism when given into the peripheral circulation?
Why does dopamine not have a therapeutic effect in parkinsonism when given into the peripheral circulation?
Which characteristic differentiates Ropinirole from Pramipexole and Rotigotine?
Which characteristic differentiates Ropinirole from Pramipexole and Rotigotine?
In what way does Rotigotine differ in administration compared to Pramipexole and Ropinirole?
In what way does Rotigotine differ in administration compared to Pramipexole and Ropinirole?
Which statement is true regarding the neuroprotective effect of Pramipexole?
Which statement is true regarding the neuroprotective effect of Pramipexole?
Which drug interaction concern is specific to Ropinirole and not associated with Pramipexole or Rotigotine?
Which drug interaction concern is specific to Ropinirole and not associated with Pramipexole or Rotigotine?
What is the primary difference between monoamine oxidase A and monoamine oxidase B?
What is the primary difference between monoamine oxidase A and monoamine oxidase B?
Why should patients avoid taking safinamide or other monoamine oxidase B inhibitors along with tramadol?
Why should patients avoid taking safinamide or other monoamine oxidase B inhibitors along with tramadol?
How does selegiline enhance the antiparkinsonism effect of levodopa?
How does selegiline enhance the antiparkinsonism effect of levodopa?
What distinguishes rasagiline from selegiline in terms of their neuroprotective effects?
What distinguishes rasagiline from selegiline in terms of their neuroprotective effects?
What adverse event should be carefully monitored when rasagiline, selegiline, or safinamide are used in combination with tricyclic antidepressants or serotonin reuptake inhibitors?
What adverse event should be carefully monitored when rasagiline, selegiline, or safinamide are used in combination with tricyclic antidepressants or serotonin reuptake inhibitors?
Which statement accurately describes the differences between tolcapone and entacapone?
Which statement accurately describes the differences between tolcapone and entacapone?
Which adverse effect of CATECHOL-O-METHYLTRANSFERASE (COMT) inhibitors is specifically related to increased levodopa exposure?
Which adverse effect of CATECHOL-O-METHYLTRANSFERASE (COMT) inhibitors is specifically related to increased levodopa exposure?
Why should tolcapone not be used in patients with abnormal liver function test results?
Why should tolcapone not be used in patients with abnormal liver function test results?
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