29 Questions
What is the primary mechanism by which nitrates reduce intracellular calcium levels?
by leading to the relaxation of smooth muscle
What was the primary reason for the limitation of nitrates' prolonged use as vasodilators?
the development of tachyphylaxis
What was the target of the alternative approach to modulate nitric oxide signaling?
phosphodiesterase type 5
What was the unforeseen adverse reaction of sildenafil observed in male patients during clinical trials for angina?
penile erection
What is the role of nitric oxide in the transmission of sexual stimulation from cavernous nerves?
it serves as the transmitter
What was the brand name under which sildenafil was approved for the treatment of male erectile dysfunction?
Viagra
What can be achieved by analyzing systematic follow-up of adverse reactions?
Development of new therapeutic outcomes
What is the main purpose of Table 2 in the article?
To showcase ongoing clinical trials in drug repurposing
Who can be involved in the work of exploiting adverse reactions?
Researchers and clinicians, as well as others
What is the focus of the article by Heerfordt et al.?
The outcomes arising from adverse drug reactions
What is the result of exploiting adverse reactions, according to the article?
Creation of new therapeutic outcomes
What was thalidomide initially marketed as in 1957?
Sedative and antiemetic medication
What was the outcome of using thalidomide during pregnancy in the 1950s and 1960s?
Over 10,000 children were born with severe deformities
What was the mechanism by which thalidomide was found to hinder cancer tumor growth?
Disruption of blood vessel formation
What is the current approved treatment for which thalidomide is used?
Refractory multiple myeloma
What type of research led to the repurposing of thalidomide?
Hypothesis-driven research
What is the characteristic of the bone marrow in multiple myeloma?
Heightened neovascularization
What is the primary use of thalidomide today?
For its antivascular effects
What is the usual dosage of domperidone for adults?
10 mg, taken up to three times daily
What adverse reactions were observed in clinical use of domperidone at elevated dosages or extended duration?
Breast discharge, breast enlargement, and breast tenderness
What was the outcome of administering domperidone to postpartum women experiencing inadequate lactation?
A slight enhancement in milk production
What is the potential application of domperidone in lactation?
To induce lactation in individuals without a preceding pregnancy
What was the range of daily domperidone doses used in case reports to induce lactation?
60 to 80 mg
What is the primary limitation of studies involving drug repurposing?
They involve relatively small and narrow populations
Where can an outline of drug repurposing studies be found?
On digital medical databases such as Micromedex or Lexicomp
What is the primary mechanism for gathering data on adverse reactions after a drug's market release?
Submission of case reports to national regulatory agencies
What is the purpose of postmarket surveillance?
To monitor pharmaceutical safety profiles
What is the significance of unintended adverse reactions in drug repurposing?
They are a source of novel therapeutic outcomes
What is the ultimate goal of medical research in the context of drug repurposing?
To revise our comprehension of drug utilization
This quiz is based on the Adverse Drug Reactions Bulletin, covering therapeutic outcomes and related topics. It assesses your knowledge of adverse drug reactions and their management. Test your understanding of this important medical topic.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
