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Questions and Answers
What is the primary mechanism by which nitrates reduce intracellular calcium levels?
What is the primary mechanism by which nitrates reduce intracellular calcium levels?
- by leading to the relaxation of smooth muscle (correct)
- by stimulating the release of nitric oxide
- by increasing phosphodiesterase type 5 activity
- by directly inhibiting calcium channels
What was the primary reason for the limitation of nitrates' prolonged use as vasodilators?
What was the primary reason for the limitation of nitrates' prolonged use as vasodilators?
- their high cost of production
- their ineffectiveness in treating angina
- the development of tachyphylaxis (correct)
- their adverse reaction of penile erection
What was the target of the alternative approach to modulate nitric oxide signaling?
What was the target of the alternative approach to modulate nitric oxide signaling?
- phosphodiesterase type 5 (correct)
- phosphodiesterase type 3
- nitric oxide release
- cGMP production
What was the unforeseen adverse reaction of sildenafil observed in male patients during clinical trials for angina?
What was the unforeseen adverse reaction of sildenafil observed in male patients during clinical trials for angina?
What is the role of nitric oxide in the transmission of sexual stimulation from cavernous nerves?
What is the role of nitric oxide in the transmission of sexual stimulation from cavernous nerves?
What was the brand name under which sildenafil was approved for the treatment of male erectile dysfunction?
What was the brand name under which sildenafil was approved for the treatment of male erectile dysfunction?
What can be achieved by analyzing systematic follow-up of adverse reactions?
What can be achieved by analyzing systematic follow-up of adverse reactions?
What is the main purpose of Table 2 in the article?
What is the main purpose of Table 2 in the article?
Who can be involved in the work of exploiting adverse reactions?
Who can be involved in the work of exploiting adverse reactions?
What is the focus of the article by Heerfordt et al.?
What is the focus of the article by Heerfordt et al.?
What is the result of exploiting adverse reactions, according to the article?
What is the result of exploiting adverse reactions, according to the article?
What was thalidomide initially marketed as in 1957?
What was thalidomide initially marketed as in 1957?
What was the outcome of using thalidomide during pregnancy in the 1950s and 1960s?
What was the outcome of using thalidomide during pregnancy in the 1950s and 1960s?
What was the mechanism by which thalidomide was found to hinder cancer tumor growth?
What was the mechanism by which thalidomide was found to hinder cancer tumor growth?
What is the current approved treatment for which thalidomide is used?
What is the current approved treatment for which thalidomide is used?
What type of research led to the repurposing of thalidomide?
What type of research led to the repurposing of thalidomide?
What is the characteristic of the bone marrow in multiple myeloma?
What is the characteristic of the bone marrow in multiple myeloma?
What is the primary use of thalidomide today?
What is the primary use of thalidomide today?
What is the usual dosage of domperidone for adults?
What is the usual dosage of domperidone for adults?
What adverse reactions were observed in clinical use of domperidone at elevated dosages or extended duration?
What adverse reactions were observed in clinical use of domperidone at elevated dosages or extended duration?
What was the outcome of administering domperidone to postpartum women experiencing inadequate lactation?
What was the outcome of administering domperidone to postpartum women experiencing inadequate lactation?
What is the potential application of domperidone in lactation?
What is the potential application of domperidone in lactation?
What was the range of daily domperidone doses used in case reports to induce lactation?
What was the range of daily domperidone doses used in case reports to induce lactation?
What is the primary limitation of studies involving drug repurposing?
What is the primary limitation of studies involving drug repurposing?
Where can an outline of drug repurposing studies be found?
Where can an outline of drug repurposing studies be found?
What is the primary mechanism for gathering data on adverse reactions after a drug's market release?
What is the primary mechanism for gathering data on adverse reactions after a drug's market release?
What is the purpose of postmarket surveillance?
What is the purpose of postmarket surveillance?
What is the significance of unintended adverse reactions in drug repurposing?
What is the significance of unintended adverse reactions in drug repurposing?
What is the ultimate goal of medical research in the context of drug repurposing?
What is the ultimate goal of medical research in the context of drug repurposing?
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