Adverse Drug Reactions and DILI
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Questions and Answers

What was the outcome of the skin prick tests in one patient who experienced an immune-mediated reaction?

  • Reaction only to sargramostim
  • Cross-reaction between the two recombinant forms of GM-CSF (correct)
  • Reaction only to filgrastim
  • No reaction to both recombinant forms of GM-CSF

What was the treatment used to resolve the symptoms of a 42-year-old woman who experienced a hypersensitivity reaction to molgramostim?

  • Intravenous injection of filgrastim
  • Adrenaline, hydrocortisone, and promethazine (correct)
  • Glucocorticoids and antihistamines
  • Desensitization protocol

What is the term used to describe the presence of pain in a specific location not spatially connected with the organ affected?

  • Hypersensitivity reaction
  • Immune-mediated reaction
  • Visceral organ cross-sensitization
  • Referred pain (correct)

What is an example of a known relation between visceral organs and skin?

<p>Heart failure and pain in the left arm and shoulder (C)</p> Signup and view all the answers

What is the explanation for the cross-talk between different DRG neurons?

<p>Spike traffic over neurons inducing inhibition or excitation of neighboring DRG neurons (A)</p> Signup and view all the answers

What is the function of the cell soma of the DRG in relation to cross-talk?

<p>Essential for spike discharge (B)</p> Signup and view all the answers

What is cross-sensitization defined as in the context of adverse drug reactions?

<p>The risk for adverse drug reactions shared by agents with close chemical structure (B)</p> Signup and view all the answers

What is an example of a therapeutic class where class effect is observed?

<p>HMG-CoA reductase inhibitors, macrolides, or thiazolidinediones (B)</p> Signup and view all the answers

Which of the following agents are known to show cross-sensitivity?

<p>Phenytoin and carbamazepine (B)</p> Signup and view all the answers

What is the observed frequency of anaphylactic reactions without immune-mediated mechanism in patients with testicular cancer given GM-CSF?

<p>8% of patients (A)</p> Signup and view all the answers

Which of the following agents are NOT known to show cross-sensitivity?

<p>Fluconazole and voriconazole (C)</p> Signup and view all the answers

What is the term for the risk for adverse drug reactions shared by different agents within a narrow therapeutic class?

<p>Class effect (A)</p> Signup and view all the answers

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