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Adverse Drug Reactions and DILI

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Questions and Answers

What was the outcome of the skin prick tests in one patient who experienced an immune-mediated reaction?

Reaction only to sargramostim

Cross-reaction between the two recombinant forms of GM-CSF (correct)

Reaction only to filgrastim

No reaction to both recombinant forms of GM-CSF

What was the treatment used to resolve the symptoms of a 42-year-old woman who experienced a hypersensitivity reaction to molgramostim?

Intravenous injection of filgrastim

Adrenaline, hydrocortisone, and promethazine (correct)

Glucocorticoids and antihistamines

Desensitization protocol

What is the term used to describe the presence of pain in a specific location not spatially connected with the organ affected?

Hypersensitivity reaction

Immune-mediated reaction

Visceral organ cross-sensitization

Referred pain (correct)

What is an example of a known relation between visceral organs and skin?

Heart failure and pain in the left arm and shoulder Signup and view all the answers

What is the explanation for the cross-talk between different DRG neurons?

Spike traffic over neurons inducing inhibition or excitation of neighboring DRG neurons Signup and view all the answers

What is the function of the cell soma of the DRG in relation to cross-talk?

Essential for spike discharge Signup and view all the answers

What is cross-sensitization defined as in the context of adverse drug reactions?

The risk for adverse drug reactions shared by agents with close chemical structure Signup and view all the answers

What is an example of a therapeutic class where class effect is observed?

HMG-CoA reductase inhibitors, macrolides, or thiazolidinediones Signup and view all the answers

Which of the following agents are known to show cross-sensitivity?

Phenytoin and carbamazepine Signup and view all the answers

What is the observed frequency of anaphylactic reactions without immune-mediated mechanism in patients with testicular cancer given GM-CSF?

8% of patients Signup and view all the answers

Which of the following agents are NOT known to show cross-sensitivity?

Fluconazole and voriconazole Signup and view all the answers

What is the term for the risk for adverse drug reactions shared by different agents within a narrow therapeutic class?

Class effect Signup and view all the answers