Advancements in Endocrinology and Diabetes Mellitus
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Questions and Answers

Which therapy led to a slightly greater reduction in A1C levels after 26 weeks?

  • Basal insulin therapy with once-weekly insulin icodec (correct)
  • Both therapies had the same effect
  • Daily insulin degludec
  • There is not enough information to determine

    • How many adults with type 2 diabetes participated in the trial?

  • 26
  • 8.6
  • 588 (correct)
  • There is not enough information to determine

    • What was the mean A1C level of the participants at the beginning of the trial?

  • Approximately 8.6 percent (correct)
  • There is not enough information to determine
  • Baseline A1C levels were not measured
  • 0.2 percentage points

    • What was the estimated treatment difference in A1C reduction between the two therapies?

    <p>-0.2 percentage points</p> Signup and view all the answers

    Which therapy had a slightly greater reduction in A1C levels?

    <p>Basal insulin therapy with once-weekly insulin icodec</p> Signup and view all the answers

    What type of diabetes was the trial focused on?

    <p>Type 2 diabetes</p> Signup and view all the answers

    What was the frequency of insulin icodec administration in the trial?

    <p>Once-weekly</p> Signup and view all the answers

    What was the frequency of insulin degludec administration in the trial?

    <p>Once-weekly</p> Signup and view all the answers

    What was the main outcome measure in the trial?

    <p>A1C reduction</p> Signup and view all the answers

    What was the difference in the number of level 2 hypoglycemic episodes between the two therapies?

    <p>Not specified in the text</p> Signup and view all the answers

    Which of the following is true about the diagnosis of adrenal insufficiency?

    <p>The morning cortisol threshold to exclude chronic adrenal insufficiency is approximately 25 to 30 percent lower with newer cortisol assays.</p> Signup and view all the answers

    What is the typical use of early morning serum cortisol levels in the diagnosis of adrenal insufficiency?

    <p>To select patients for additional evaluation with corticotropin (ACTH) stimulation testing.</p> Signup and view all the answers

    What is the interpretation of the serum cortisol result dependent on when evaluating patients for chronic adrenal insufficiency?

    <p>The type of assay used to measure cortisol.</p> Signup and view all the answers

    What is the morning cortisol threshold to exclude chronic adrenal insufficiency with older immunoassays?

    <p>18 mcg/dL</p> Signup and view all the answers

    What is the morning cortisol threshold to exclude chronic adrenal insufficiency with newer cortisol assays?

    <p>13 to 14 mcg/dL</p> Signup and view all the answers

    What is the purpose of corticotropin (ACTH) stimulation testing?

    <p>To select patients for additional evaluation.</p> Signup and view all the answers

    What is the influence of cortisol assay technique on the diagnosis of adrenal insufficiency?

    <p>It may lead to underdiagnosis of adrenal insufficiency.</p> Signup and view all the answers

    What is the approximate percentage difference in morning cortisol threshold between older immunoassays and newer cortisol assays?

    <p>25 to 30 percent lower with newer cortisol assays</p> Signup and view all the answers

    What is the unit of measurement for cortisol levels in the text?

    <p>mcg/dL</p> Signup and view all the answers

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