Advancements in Cardiology
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Which risk score outperformed the Framingham-AF and ARIC risk models and was comparable to the CHARGE-AF risk score?

  • ARIC risk score
  • Framingham-AF risk score
  • CHARGE-AF risk score
  • HARMS2-AF risk score (correct)

    • What is the incidence of AF among UKB patients?

  • 8.2%
  • 6.9%
  • 4.3%
  • 5.7% (correct)

    • Which of the following is not a predictor of AF according to the HARMS2-AF risk score?

  • Raised BMI
  • Diabetes (correct)
  • Age
  • Hypertension

    • What is considered an intermediate risk score according to the HARMS2-AF risk score?

    <p>5-9 points</p> Signup and view all the answers

    What is the main benefit of the HARMS2-AF risk score?

    <p>Predicting AF risk</p> Signup and view all the answers

    Which study investigated the effect of home telemonitoring systems (hTMS) on clinical outcomes in patients with HF?

    <p>Dutch meta-analysis</p> Signup and view all the answers

    What was the reduction in all-cause mortality in patients using hTMS compared to standard of care according to the meta-analysis?

    <p>16%</p> Signup and view all the answers

    What was the reduction in first HF hospitalizations in patients using hTMS compared to standard of care according to the meta-analysis?

    <p>20%</p> Signup and view all the answers

    What was the reduction in total HF hospitalizations in patients using hTMS compared to standard of care according to the meta-analysis?

    <p>15%</p> Signup and view all the answers

    What was the main driver of mortality reduction in patients using hTMS according to the meta-analysis?

    <p>Structural telephone support (STS)</p> Signup and view all the answers

    Which population was used to develop the HARMS2-AF risk score?

    <p>UK Biobank participants</p> Signup and view all the answers

    What is the incidence of AF among UK Biobank participants?

    <p>5.7%</p> Signup and view all the answers

    Which of the following variables were found to be predictive for AF in the HARMS2-AF risk score?

    <p>Hypertension, age, BMI, male sex, sleep apnoea, smoking, and alcohol</p> Signup and view all the answers

    What was the median time to AF among UK Biobank participants?

    <p>7.6 years</p> Signup and view all the answers

    What was the purpose of the Dutch study mentioned in the text?

    <p>To investigate the use of home telemonitoring systems in patients with HF</p> Signup and view all the answers

    What did the local study in NZ find about ethnic inequities in HF hospitalizations?

    <p>They are widening</p> Signup and view all the answers

    What was the topic of the article about upgrading from right ventricular pacing to CRT?

    <p>Patients with HF</p> Signup and view all the answers

    What was the topic of the article about semaglutide?

    <p>Patients with HFpEF and obesity</p> Signup and view all the answers

    What was the topic of the article comparing optical coherence tomography and angiography guidance?

    <p>PCI in complex bifurcation lesions</p> Signup and view all the answers

    What was the topic of the article about ferric carboxymaltose?

    <p>Its impact in HF patients with iron deficiency</p> Signup and view all the answers

    According to the meta-analysis, what was the reduction in all-cause mortality in patients using home telemonitoring systems (hTMS) compared to standard of care?

    <p>16%</p> Signup and view all the answers

    What is the range for an intermediate risk score according to the HARMS2-AF risk score?

    <p>5-9 points</p> Signup and view all the answers

    What was the incidence of atrial fibrillation (AF) among UK Biobank (UKB) participants?

    <p>5.7%</p> Signup and view all the answers

    Which of the following variables were found to be predictive for AF in the HARMS2-AF risk score?

    <p>Sleep apnea</p> Signup and view all the answers

    Which risk score outperformed the Framingham-AF and ARIC risk models and was comparable to the CHARGE-AF risk score?

    <p>HARMS2-AF risk score</p> Signup and view all the answers

    What was the main driver of mortality reduction in patients using home telemonitoring systems (hTMS) according to the meta-analysis?

    <p>Structural telephone support</p> Signup and view all the answers

    Which study investigated the effect of home telemonitoring systems (hTMS) on clinical outcomes in patients with heart failure (HF)?

    <p>Eur Heart J 2023;44(31):2911-26</p> Signup and view all the answers

    What was the reduction in first heart failure (HF) hospitalizations in patients using home telemonitoring systems (hTMS) compared to standard of care according to the meta-analysis?

    <p>19%</p> Signup and view all the answers

    What was the topic of the Dutch study mentioned in the text?

    <p>Telemonitoring for heart failure</p> Signup and view all the answers

    What was the topic of the article comparing optical coherence tomography and angiography guidance?

    <p>Optical coherence tomography and angiography guidance</p> Signup and view all the answers

    Which lifestyle factors were found to be predictive variables for AF in the HARMS2-AF risk score?

    <p>Hypertension, age, BMI, male sex, sleep apnoea, smoking, and alcohol</p> Signup and view all the answers

    What was the median time to AF among UK Biobank participants?

    <p>7.6 years</p> Signup and view all the answers

    What was the incidence of AF among UK Biobank participants?

    <p>5.7%</p> Signup and view all the answers

    What is considered an intermediate risk score according to the HARMS2-AF risk score?

    <p>5-9</p> Signup and view all the answers

    What was the topic of the article about upgrading from right ventricular pacing to CRT?

    <p>Upgrade from right ventricular pacing to CRT in patients with HF</p> Signup and view all the answers

    Which of the following variables were found to be predictive for AF in the HARMS2-AF risk score?

    <p>Hypertension, age, BMI, male sex, sleep apnoea, smoking, and alcohol</p> Signup and view all the answers

    What was the reduction in total HF hospitalizations in patients using hTMS compared to standard of care according to the meta-analysis?

    <p>40%</p> Signup and view all the answers

    What was the topic of the article about ferric carboxymaltose?

    <p>Impact of ferric carboxymaltose in HF patients with iron deficiency</p> Signup and view all the answers

    What was the reduction in all-cause mortality in patients using hTMS compared to standard of care according to the meta-analysis?

    <p>50%</p> Signup and view all the answers

    What was the purpose of the Dutch study mentioned in the text?

    <p>To investigate the effect of home telemonitoring systems (hTMS) on clinical outcomes in patients with HF</p> Signup and view all the answers

    What was the primary outcome measure in the study?

    <p>Percentage of predicted FEV1</p> Signup and view all the answers

    What was the difference in the percentage of predicted FEV1 between the treatment group and the placebo group at 4 weeks?

    <p>13.8 points higher</p> Signup and view all the answers

    What was the rate of pulmonary exacerbations in the treatment group compared to the placebo group?

    <p>63% lower</p> Signup and view all the answers

    What was the difference in the respiratory domain score on the Cystic Fibrosis Questionnaire between the treatment group and the placebo group?

    <p>20.2 points higher</p> Signup and view all the answers

    What was the difference in the sweat chloride concentration between the treatment group and the placebo group?

    <p>41.8 mmol per liter lower</p> Signup and view all the answers

    How long was the study duration?

    <p>24 weeks</p> Signup and view all the answers

    How many patients underwent randomization and received at least one dose of active treatment or placebo?

    <p>403</p> Signup and view all the answers

    Who were the contributing authors of the article?

    <p>Drs. Middleton and Mall and Drs. Rowe and Jain</p> Signup and view all the answers

    When was the article published?

    <p>October 31, 2019</p> Signup and view all the answers

    What is the DOI of the article?

    <p>10.1056/NEJMoa1908639</p> Signup and view all the answers

    What is the primary end point of the phase 3 trial mentioned in the text?

    <p>Change in FEV1 at week 4</p> Signup and view all the answers

    What is the most common mutation in patients with cystic fibrosis?

    <p>Phe508del</p> Signup and view all the answers

    Which combination of drugs was used in the phase 2 trial mentioned in the text?

    <p>Elexacaftor, tezacaftor, and ivacaftor</p> Signup and view all the answers

    What is the age range of the patients included in the phase 3 trial?

    <p>12 years of age or older</p> Signup and view all the answers

    What was the duration of the phase 3 trial?

    <p>24 weeks</p> Signup and view all the answers

    What was the design of the phase 3 trial?

    <p>Randomized, double-blind, placebo-controlled</p> Signup and view all the answers

    What was the genotype of the patients included in the phase 3 trial?

    <p>Phe508del–minimal function</p> Signup and view all the answers

    What was the aim of the phase 2 trial mentioned in the text?

    <p>To evaluate the efficacy of elexacaftor, tezacaftor, and ivacaftor</p> Signup and view all the answers

    What is the name of the CFTR corrector used in the phase 2 trial?

    <p>Elexacaftor</p> Signup and view all the answers

    What was the primary outcome measure in the phase 2 trial?

    <p>Change in CFTR function</p> Signup and view all the answers

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