60 Questions
Which risk score outperformed the Framingham-AF and ARIC risk models and was comparable to the CHARGE-AF risk score?
HARMS2-AF risk score
What is the incidence of AF among UKB patients?
5.7%
Which of the following is not a predictor of AF according to the HARMS2-AF risk score?
Diabetes
What is considered an intermediate risk score according to the HARMS2-AF risk score?
5-9 points
What is the main benefit of the HARMS2-AF risk score?
Predicting AF risk
Which study investigated the effect of home telemonitoring systems (hTMS) on clinical outcomes in patients with HF?
Dutch meta-analysis
What was the reduction in all-cause mortality in patients using hTMS compared to standard of care according to the meta-analysis?
16%
What was the reduction in first HF hospitalizations in patients using hTMS compared to standard of care according to the meta-analysis?
20%
What was the reduction in total HF hospitalizations in patients using hTMS compared to standard of care according to the meta-analysis?
15%
What was the main driver of mortality reduction in patients using hTMS according to the meta-analysis?
Structural telephone support (STS)
Which population was used to develop the HARMS2-AF risk score?
UK Biobank participants
What is the incidence of AF among UK Biobank participants?
5.7%
Which of the following variables were found to be predictive for AF in the HARMS2-AF risk score?
Hypertension, age, BMI, male sex, sleep apnoea, smoking, and alcohol
What was the median time to AF among UK Biobank participants?
7.6 years
What was the purpose of the Dutch study mentioned in the text?
To investigate the use of home telemonitoring systems in patients with HF
What did the local study in NZ find about ethnic inequities in HF hospitalizations?
They are widening
What was the topic of the article about upgrading from right ventricular pacing to CRT?
Patients with HF
What was the topic of the article about semaglutide?
Patients with HFpEF and obesity
What was the topic of the article comparing optical coherence tomography and angiography guidance?
PCI in complex bifurcation lesions
What was the topic of the article about ferric carboxymaltose?
Its impact in HF patients with iron deficiency
According to the meta-analysis, what was the reduction in all-cause mortality in patients using home telemonitoring systems (hTMS) compared to standard of care?
16%
What is the range for an intermediate risk score according to the HARMS2-AF risk score?
5-9 points
What was the incidence of atrial fibrillation (AF) among UK Biobank (UKB) participants?
5.7%
Which of the following variables were found to be predictive for AF in the HARMS2-AF risk score?
Sleep apnea
Which risk score outperformed the Framingham-AF and ARIC risk models and was comparable to the CHARGE-AF risk score?
HARMS2-AF risk score
What was the main driver of mortality reduction in patients using home telemonitoring systems (hTMS) according to the meta-analysis?
Structural telephone support
Which study investigated the effect of home telemonitoring systems (hTMS) on clinical outcomes in patients with heart failure (HF)?
Eur Heart J 2023;44(31):2911-26
What was the reduction in first heart failure (HF) hospitalizations in patients using home telemonitoring systems (hTMS) compared to standard of care according to the meta-analysis?
19%
What was the topic of the Dutch study mentioned in the text?
Telemonitoring for heart failure
What was the topic of the article comparing optical coherence tomography and angiography guidance?
Optical coherence tomography and angiography guidance
Which lifestyle factors were found to be predictive variables for AF in the HARMS2-AF risk score?
Hypertension, age, BMI, male sex, sleep apnoea, smoking, and alcohol
What was the median time to AF among UK Biobank participants?
7.6 years
What was the incidence of AF among UK Biobank participants?
5.7%
What is considered an intermediate risk score according to the HARMS2-AF risk score?
5-9
What was the topic of the article about upgrading from right ventricular pacing to CRT?
Upgrade from right ventricular pacing to CRT in patients with HF
Which of the following variables were found to be predictive for AF in the HARMS2-AF risk score?
Hypertension, age, BMI, male sex, sleep apnoea, smoking, and alcohol
What was the reduction in total HF hospitalizations in patients using hTMS compared to standard of care according to the meta-analysis?
40%
What was the topic of the article about ferric carboxymaltose?
Impact of ferric carboxymaltose in HF patients with iron deficiency
What was the reduction in all-cause mortality in patients using hTMS compared to standard of care according to the meta-analysis?
50%
What was the purpose of the Dutch study mentioned in the text?
To investigate the effect of home telemonitoring systems (hTMS) on clinical outcomes in patients with HF
What was the primary outcome measure in the study?
Percentage of predicted FEV1
What was the difference in the percentage of predicted FEV1 between the treatment group and the placebo group at 4 weeks?
13.8 points higher
What was the rate of pulmonary exacerbations in the treatment group compared to the placebo group?
63% lower
What was the difference in the respiratory domain score on the Cystic Fibrosis Questionnaire between the treatment group and the placebo group?
20.2 points higher
What was the difference in the sweat chloride concentration between the treatment group and the placebo group?
41.8 mmol per liter lower
How long was the study duration?
24 weeks
How many patients underwent randomization and received at least one dose of active treatment or placebo?
403
Who were the contributing authors of the article?
Drs. Middleton and Mall and Drs. Rowe and Jain
When was the article published?
October 31, 2019
What is the DOI of the article?
10.1056/NEJMoa1908639
What is the primary end point of the phase 3 trial mentioned in the text?
Change in FEV1 at week 4
What is the most common mutation in patients with cystic fibrosis?
Phe508del
Which combination of drugs was used in the phase 2 trial mentioned in the text?
Elexacaftor, tezacaftor, and ivacaftor
What is the age range of the patients included in the phase 3 trial?
12 years of age or older
What was the duration of the phase 3 trial?
24 weeks
What was the design of the phase 3 trial?
Randomized, double-blind, placebo-controlled
What was the genotype of the patients included in the phase 3 trial?
Phe508del–minimal function
What was the aim of the phase 2 trial mentioned in the text?
To evaluate the efficacy of elexacaftor, tezacaftor, and ivacaftor
What is the name of the CFTR corrector used in the phase 2 trial?
Elexacaftor
What was the primary outcome measure in the phase 2 trial?
Change in CFTR function
Test your knowledge on recent advancements and research in cardiology with this quiz. Explore topics such as the HARMS2-AF risk score, home telemonitoring systems for patients with heart failure, ethnic inequities in heart failure hospitalizations, CRT in patients with heart failure, Semaglutide for patients with HFpEF and obesity, and optical coherence tomography vs angiography guidance for PCI. Stay up-to-date and expand your understanding of cardiology research.
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