5 Questions
Which enzyme is responsible for the conversion of tyrosine to DOPA?
Tyrosine hydroxylase
Which receptor subtype is primarily involved in vasoconstriction of blood vessels?
$\alpha1$
Which adrenergic receptor subtype is primarily involved in vasodilation of the liver?
$\beta2$
Which enzyme is responsible for the degradation of catecholamines outside the neuronal cells?
COMT
What is the primary neurotransmitter released from postganglionic sympathetic nerve endings?
$\text{NE}$
Study Notes
Catecholamine Synthesis and Degradation
- Tyrosine is converted to DOPA by the enzyme tyrosine hydroxylase.
Adrenergic Receptor Subtypes
- The alpha-1 receptor subtype is primarily involved in vasoconstriction of blood vessels.
- The beta-2 receptor subtype is primarily involved in vasodilation of the liver.
Catecholamine Degradation
- The enzyme catechol-O-methyltransferase (COMT) is responsible for the degradation of catecholamines outside the neuronal cells.
Sympathetic Nerve Endings
- The primary neurotransmitter released from postganglionic sympathetic nerve endings is norepinephrine.
Test your knowledge of adrenergic transmission in pharmacology with this quiz. Topics covered include the synthesis, release, and function of norepinephrine, adrenaline, and related pathways.
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