PHY-C Adrenal Gland Physiology: Hormone Biosynthesis and Secretion

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Questions and Answers

What is the primary function of mineralocorticoids?

  • Controlling electrolyte balance (sodium and potassium) (correct)
  • Regulating blood glucose concentration
  • Influencing the response to stress
  • Increasing protein and fat metabolism

Which hormones are considered mineralocorticoids?

  • Cortisol and adrenaline
  • Cortisol and androgens
  • Aldosterone and cortisol (correct)
  • Aldosterone and androgens

From which part of the adrenal glands are mineralocorticoids primarily secreted?

  • Neural crest cells
  • Adrenal medulla
  • Suprarenal arteries
  • Adrenal cortex (correct)

What is the main physiological action of glucocorticoids?

<p>Increase in blood glucose concentration (B)</p> Signup and view all the answers

Which embryologic origin influences the mechanisms that control glucocorticoid production?

<p>Mesoderm (B)</p> Signup and view all the answers

What are the two exceptional steroids produced by the adrenal cortex?

<p>Glucocorticoids and aldosterone (D)</p> Signup and view all the answers

Which arteries supply blood to the adrenal glands?

<p>Superior, middle, and inferior suprarenal arteries (C)</p> Signup and view all the answers

What is the role of mineralocorticoids?

<p>Controlling electrolytes (Na – K) (C)</p> Signup and view all the answers

Which embryologic origin influences the mechanisms that control hormone production in the adrenal glands?

<p>Mesoderm (D)</p> Signup and view all the answers

What is the primary function of glucocorticoids?

<p>Regulating blood glucose concentration (C)</p> Signup and view all the answers

Which arteries supply blood to the adrenal glands?

<p>Superior, middle, and inferior suprarenal arteries (D)</p> Signup and view all the answers

What is the primary function of mineralocorticoids in the adrenal cortex?

<p>Control electrolytes (Na - K) (D)</p> Signup and view all the answers

Which enzyme is involved in the biosynthesis of cortisol in the adrenal cortex?

<p>CYP17A1 (D)</p> Signup and view all the answers

What is the acute regulatory mechanism for the production of cathecolamines?

<p>Sympathetic nervous system activation (D)</p> Signup and view all the answers

Which mineralocorticoid receptor is primarily located in the cytoplasm and translocates into the nucleus upon activation?

<p>Mineralocorticoid receptor type 1 (MR1) (C)</p> Signup and view all the answers

Which hormones are regulated by independent mechanisms in the adrenal cortex?

<p>Aldosterone and glucocorticoids (A)</p> Signup and view all the answers

What is the main difference between acute and chronic stimulation in steroidogenesis?

<p>Acute regulation involves rapid production in response to immediate needs, while chronic stimulation enhances synthetic capacity over time. (C)</p> Signup and view all the answers

Which pituitary hormone is primarily involved in regulating glucocorticoid synthesis in the adrenal cortex?

<p>Adrenocorticotropic hormone (ACTH) (C)</p> Signup and view all the answers

Where is the initial step of steroid hormone synthesis located in adrenal cortex cells?

<p>In the mitochondria (B)</p> Signup and view all the answers

What is the role of the STeroid Acute Regulatory (STAR) protein in steroid hormone synthesis?

<p>Catalyzing the conversion of cholesterol to pregnenolone (C)</p> Signup and view all the answers

Which enzyme system catalyzes the conversion of pregnenolone to progesterone or 17α-OHpregnenolone?

<p>3β-hydroxysteroid dehydrogenase (D)</p> Signup and view all the answers

What is the primary difference between Zona glomerulosa and Zona fasciculata in terms of enzyme activity?

<p>Zona glomerulosa has aldosterone synthase activity, while Zona fasciculata has 17α-hydroxylase activity (D)</p> Signup and view all the answers

What stimulates the release of cortisol following a surge in ACTH?

<p>Corticotropin-releasing hormone (CRH) (C)</p> Signup and view all the answers

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