Adaptive Immunity: T Cells Overview
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Questions and Answers

What type of cells express MHC class II?

  • Cytotoxic T cells
  • All nucleated cells
  • Helper T cells
  • Dendritic cells, macrophages, and B cells (correct)
  • What type of antigen is presented by MHC class II?

  • Exogenous antigen (correct)
  • Allergen
  • Endogenous antigen
  • Autoantigen
  • Which type of T cell is activated by MHC class II?

  • Regulatory T cells
  • Memory T cells
  • Helper T cells (correct)
  • Cytotoxic T cells
  • What is the role of co-stimulation in the activation of helper T cells?

    <p>Co-stimulation provides a second signal, ensuring that the helper T cell is only activated by an appropriate antigen. (D)</p> Signup and view all the answers

    How do cytotoxic T cells eliminate infected cells?

    <p>By directly killing the infected cells through the release of cytotoxic granules. (D)</p> Signup and view all the answers

    What is the role of memory T cells in the immune response?

    <p>Memory T cells are responsible for providing a faster and more efficient response to subsequent encounters with the same pathogen. (D)</p> Signup and view all the answers

    What is the difference between immediate and delayed hypersensitivity?

    <p>Immediate hypersensitivity is a rapid response that occurs within minutes of exposure to an allergen, while delayed hypersensitivity is a slower response that takes several days to develop. (A)</p> Signup and view all the answers

    Why is it important to know your blood type?

    <p>Knowing your blood type is important for blood transfusions and organ donations. (A)</p> Signup and view all the answers

    What is the primary role of T cell receptors in the immune system?

    <p>To bind to antigens presented by major histocompatibility complex (MHC) (D)</p> Signup and view all the answers

    What characterizes adaptive immunity compared to innate immunity?

    <p>It involves memory cells that improve response on re-exposure (B)</p> Signup and view all the answers

    How does the immune system fail in some situations?

    <p>By recognizing self-cells as foreign, resulting in autoimmune diseases (B), By overreacting to benign substances, causing allergies (C)</p> Signup and view all the answers

    What is the significance of knowing an individual's blood type?

    <p>It is crucial for safe blood transfusions and understanding Rh factor interactions (D)</p> Signup and view all the answers

    What occurs during a blood transfusion if antigens on donor red blood cells meet antibodies in the recipient's plasma?

    <p>Agglutination (D)</p> Signup and view all the answers

    What is the role of MHC in T cell activation?

    <p>It presents antigens to T cells for recognition (B)</p> Signup and view all the answers

    Which blood type can universally donate to all blood types without causing agglutination?

    <p>Type O (B)</p> Signup and view all the answers

    What can lead to the development of anti-D antibodies in an Rh- individual?

    <p>Transfusion of Rh+ blood (D)</p> Signup and view all the answers

    Which of the following is NOT a symptom of hemolytic disease of the newborn?

    <p>Severe dehydration (D)</p> Signup and view all the answers

    How do doctors typically prevent hemolytic disease of the newborn?

    <p>Administering Rh immunoglobulin to the Rh- mother (B)</p> Signup and view all the answers

    What is the primary function of B lymphocytes?

    <p>Recognize pathogens and produce antibodies (C)</p> Signup and view all the answers

    What prevents a Rh- mother from producing anti-D antigen antibodies in a subsequent pregnancy with an Rh+ fetus?

    <p>Anti-D antigen antibodies are injected and remove fetal red blood cells. (B)</p> Signup and view all the answers

    Which type of cell is primarily responsible for ingesting and destroying invaders?

    <p>Neutrophils (D)</p> Signup and view all the answers

    Which of the following is NOT a type of lymphocyte?

    <p>Macrophages (D)</p> Signup and view all the answers

    What term refers to the cells that can present antigens to initiate a specific immune response?

    <p>Antigen-presenting cells (C)</p> Signup and view all the answers

    Which percentage range best represents the amount of neutrophils in the blood?

    <p>50–70% (C)</p> Signup and view all the answers

    Which immune cell type is characterized as a granulocyte?

    <p>Eosinophils (A)</p> Signup and view all the answers

    Which cells are referred to as 'polys' due to their structure?

    <p>Neutrophils (C)</p> Signup and view all the answers

    Flashcards

    T cell activation

    The process by which T lymphocytes become activated upon binding to an MHC-antigen complex.

    Innate Immunity

    A rapid and non-specific immune response that provides immediate defense against pathogens.

    Adaptive Immunity

    A slower and specific immune response that develops after exposure to an antigen.

    MHC (Major Histocompatibility Complex)

    Proteins on cell surfaces that present antigens to T cells, essential for T cell activation.

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    Rh factor and pregnancy

    The Rh factor is a blood group antigen that can affect pregnancy outcomes related to hemolytic disease in newborns.

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    Cross-reactions

    Occur when donor RBC antigens react with recipient antibodies during transfusion.

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    Blood type compatibility

    Determines if blood transfusion will cause agglutination based on donors and recipients.

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    Anti-D antibodies

    Antibodies that develop in Rh- individuals after exposure to Rh+ blood.

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    Hemolytic disease of the newborn

    Condition caused by Rh incompatibility; leads to anemia and jaundice in newborn.

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    Rh factor

    D antigen that determines if blood is Rh+ or Rh-.

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    MHC Class II

    Molecules on dendritic cells, macrophages, and B cells that present exogenous antigens to activate helper T cells.

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    Helper T cells

    Type of T cell that is activated by MHC Class II and stimulates other immune cells.

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    Cytokines

    Signaling proteins that stimulate growth and activity of immune cells, including T cells and B cells.

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    MHC Class I

    Molecules on all nucleated cells that present endogenous antigens to activate cytotoxic T cells.

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    Cytotoxic T cells

    Type of T cell activated by MHC Class I; responsible for killing infected or cancerous cells.

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    Immediate hypersensitivity

    Rapid immune response resulting in strong reactions like rashes or anaphylaxis upon re-exposure to an antigen.

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    Blood Types

    Classification of blood based on the presence of specific antigens and their compatibility for transfusion.

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    Anti-D antigen antibodies

    Antibodies injected into Rh- mothers to prevent immune response.

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    Immune response prevention

    The process by which maternal immune system is prevented from reacting to fetal antigens.

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    Rh+ fetus

    A fetus with positive Rh factor that poses risks for Rh- mothers.

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    Types of leukocytes

    Different types of white blood cells, each with specific functions.

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    Phagocytes

    Cells that ingest and destroy invaders like bacteria.

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    Granulocytes

    White blood cells with granules, crucial for immune response.

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    Antigen-presenting cells

    Cells that display antigens to T cells to trigger an immune response.

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    Study Notes

    Adaptive Immunity: T cells and The Immune System

    • Adaptive immunity is a slower, specific response to pathogens than innate immunity
    • T cells recognize antigens presented by MHC molecules
    • T cell activation involves a cell binding to a T lymphocyte and signal transduction activating the T lymphocyte
    • T cells are categorized as helper T cells, regulatory T cells, and cytotoxic T cells
    • Helper T cells release cytokines to activate other immune cells
    • Cytotoxic T cells kill target cells using perforin and granzymes or by activating 'death receptors'
    • MHC class II molecules are found on dendritic cells, macrophages, and B cells; they're crucial for presenting exogenous antigens and activating helper T cells
    • MHC class I molecules are found on all nucleated cells; they present endogenous antigens and activate cytotoxic T cells
    • T cell activation is triggered by the binding of the T-cell receptor to MHC bound to antigen
    • Immediate hypersensitivity is an exaggerated immune response to an allergen, involving IgE antibodies
    • Knowing blood type prevents transfusion reactions
    • Individuals with Rh- blood type expecting an Rh+ baby are treated with anti-D antibodies to prevent hemolytic disease of the newborn
    • Antibodies act as opsonins, coating viral particles to target them for macrophages

    Blood Types and Blood Donation

    • ABO blood groups include type A, type B, type AB, and type O
    • Type A blood has surface antigen A and anti-B antibodies
    • Type B blood has surface antigen B and anti-A antibodies
    • Type AB blood has both surface antigens A and B and neither anti-A nor anti-B antibodies
    • Type O blood has neither surface antigen A nor B and both anti-A and anti-B antibodies
    • Europeans have 85% Rh+, 15% Rh-
    • Asians, Africans, Native Americans are almost 99% Rh+ and 1% Rh-
    • Cross-reactions during blood transfusions occur if donor antigens meet recipient antibodies
    • Type B blood donors to type A recipients cause agglutination (clumping) and hemolysis

    Immune System and Disease

    • An immune response can be either protective or deficient, depending on the nature of the antigen (pathogen or not)
    • Antigen types that trigger a deficient response include infectious agents (causing recurrent infections), innocuous substances (causing allergies), transplanted tissue (causing tissue rejection), self-tissue (causing autoimmunity), and tumors (causing cancer)

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    Description

    Explore the crucial role of T cells in adaptive immunity and their interactions with MHC molecules. This quiz covers T cell activation, types of T cells, and their functions in the immune response. Test your understanding of how these cells protect the body against pathogens.

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