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Questions and Answers
Which class of antibody primarily indicates a primary immune response?
Which class of antibody primarily indicates a primary immune response?
What is the primary function of Helper T cells?
What is the primary function of Helper T cells?
Which type of vaccine is designed to provide immunity through the use of live, weakened microbes?
Which type of vaccine is designed to provide immunity through the use of live, weakened microbes?
What type of immunity is achieved when the body produces its own antibodies in response to infection?
What type of immunity is achieved when the body produces its own antibodies in response to infection?
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Which class of antibody is most abundant in circulation and can cross the placenta?
Which class of antibody is most abundant in circulation and can cross the placenta?
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Which of the following antibody classes is primarily involved in allergic reactions?
Which of the following antibody classes is primarily involved in allergic reactions?
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What is the main characteristic of subunit vaccines?
What is the main characteristic of subunit vaccines?
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Which type of T cell is primarily responsible for stimulating macrophages to destroy bacteria?
Which type of T cell is primarily responsible for stimulating macrophages to destroy bacteria?
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What is considered an example of artificial passive immunity?
What is considered an example of artificial passive immunity?
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Which antibody class has 10 binding sites and is associated with the first immune response?
Which antibody class has 10 binding sites and is associated with the first immune response?
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What is the primary response in adaptive immunity?
What is the primary response in adaptive immunity?
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Which antibody is first produced during a primary immune response?
Which antibody is first produced during a primary immune response?
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What is the main difference between humoral and cellular immunity?
What is the main difference between humoral and cellular immunity?
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What is clonal selection in adaptive immunity?
What is clonal selection in adaptive immunity?
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What is the primary function of effector cells?
What is the primary function of effector cells?
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Which region of an antibody binds to antigens?
Which region of an antibody binds to antigens?
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What do memory cells do in adaptive immunity?
What do memory cells do in adaptive immunity?
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What is the structure of an antibody composed of?
What is the structure of an antibody composed of?
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What is the function of the Fc region in antibodies?
What is the function of the Fc region in antibodies?
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What do B cells primarily target in the body?
What do B cells primarily target in the body?
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Study Notes
Adaptive Immunity
- Primary response: Occurs during first exposure to a pathogen; lower antibody concentration. IgM is produced first, followed by IgG.
- Secondary response: Faster, stronger, and higher antibody concentration. Primarily involves IgG production.
- Humoral immunity: Antibody-mediated; involves B cells targeting extracellular pathogens.
- Cellular immunity: Cell-mediated; involves T cells targeting infected or abnormal cells.
Lymphocytes
- B cells: Remain in bone marrow; produce antibodies targeting extracellular pathogens.
- T cells: Pass through thymus; involved in cellular immunity, targeting infected or abnormal cells.
- Epitopes: Regions on antigens recognised by immune cells (B and T cells).
- Clonal selection: Process activating B and T cells specific to an antigen leading to effector and memory cells.
Antibodies
- Structure: Two heavy chains and two light chains.
- Fab region: Antigen-binding site; highly variable.
- Fc region: Facilitates binding to phagocytes and complement system.
- IgM: First antibody produced during primary response; 10 binding sites. Indicates initial immune response.
- IgG: Most abundant, crosses placenta; provides long-term immunity.
- IgA: Mucosal immunity; found in bodily fluids (e.g., saliva, tears).
- IgE: Involved in allergic reactions.
- IgD: B cell receptor.
T Lymphocytes
- Helper T cells (TH): Regulate immune responses, including antibody production.
- TH1: Stimulates macrophages to destroy bacteria.
- TH2: Promotes humoral immunity by aiding B cells.
- Cytotoxic T cells (CTLs): Eliminate infected or tumor cells.
Vaccines
- Live attenuated vaccines: Weakened microbes for strong immune response.
- Inactivated vaccines: Killed pathogens; require boosters for long-term immunity.
- Subunit vaccines: Antigen fragments; cannot cause disease.
- Toxoid vaccines: Inactivated toxins; require boosters.
- Conjugate vaccines: Combine weak antigens with stronger ones to improve immune response.
Immunity
- Active immunity: Body produces its own antibodies.
- Natural: Infection.
- Artificial: Vaccination (e.g., injection of weakened, dead virus).
- Passive immunity: Body receives antibodies from another source.
- Natural: Maternal antibodies (placenta or breast milk).
- Artificial: Injection of antibodies.
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Description
Test your understanding of adaptive immunity concepts, including primary and secondary immune responses, the roles of B and T cells, and the structure and function of antibodies. This quiz covers key topics such as clonal selection and humoral versus cellular immunity.
