Acute Inflammation and Treatment
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Questions and Answers

What is the primary function of vasodilation during the inflammatory response?

  • To stimulate pain receptors in the area
  • To release histamine and stimulate mast cells
  • To constrict blood vessels and limit bleeding
  • To increase blood flow to the injured area (correct)

    • What happens to arterioles in the immediate aftermath of an injury?

  • They undergo vasodilation
  • They release prostaglandins
  • They become permeable to leukocytes
  • They go into spasm and constrict (correct)

    • What is the role of endothelial cells in the inflammatory response?

  • To retract and allow leukocytes to migrate into the interstitial space (correct)
  • To release histamine and stimulate mast cells
  • To stimulate pain receptors in the area
  • To increase capillary permeability

    • What is the purpose of fibrin in the inflammatory response?

    <p>To contain foreign substances and promote healing</p> Signup and view all the answers

    What happens to capillary permeability during the inflammatory response?

    <p>It increases to allow leukocytes to migrate</p> Signup and view all the answers

    What type of cells are involved in phagocytosis during the inflammatory response?

    <p>Neutrophils and monocytes</p> Signup and view all the answers

    What happens to blood vessels during the inflammatory response?

    <p>They become more permeable to leukocytes</p> Signup and view all the answers

    What is the ultimate goal of the inflammatory response?

    <p>To contain and eliminate foreign substances and promote healing</p> Signup and view all the answers

    What is the primary goal of administering aspirin and other non-steroidal anti-inflammatory agents in the treatment of acute inflammation?

    <p>To relieve pain and fever</p> Signup and view all the answers

    What is the systemic response following local inflammation known as?

    <p>Acute-phase response</p> Signup and view all the answers

    What is the result of chronic inflammation in tissues?

    <p>Breakdown of healthy tissue</p> Signup and view all the answers

    Which of the following diseases is characterized by chronic inflammation?

    <p>All of the above</p> Signup and view all the answers

    What is the role of leukocytes in chronic inflammation?

    <p>They amplify the inflammatory response</p> Signup and view all the answers

    What is the result of chronic inflammation in terms of cancer risk?

    <p>It increases the risk of developing many types of cancer</p> Signup and view all the answers

    What is the first stage of wound healing?

    <p>Hemostasis</p> Signup and view all the answers

    What is the purpose of the inflammation phase in wound healing?

    <p>To clear out damaged and dead cells</p> Signup and view all the answers

    What is the primary role of pyrogens in the immune response?

    <p>To create an unpleasant environment for bacterial growth by producing fever</p> Signup and view all the answers

    What is the primary function of interferons in the immune response?

    <p>To trigger the synthesis of enzymes that inhibit viral replication</p> Signup and view all the answers

    What is the typical duration of acute inflammation?

    <p>A few days</p> Signup and view all the answers

    What is the primary benefit of acute inflammation?

    <p>To immobilize the area of injury as the rest of the immune system mobilizes to heal</p> Signup and view all the answers

    What is the role of the spleen and liver during mild fevers?

    <p>To remove iron from the blood, which is required by many bacteria to reproduce</p> Signup and view all the answers

    What is the effect of fever on the spread of viral infections?

    <p>Fever inhibits the spread of viral infections</p> Signup and view all the answers

    What is the primary function of vascular stages in the inflammatory response?

    <p>To increase blood flow and lead to changes in the small blood vessels of the microcirculation</p> Signup and view all the answers

    What is the benefit of interferon production in the immune response?

    <p>It stops the spread of the virus to new cells</p> Signup and view all the answers

    Study Notes

    Inflammatory Response

    • The treatment of acute inflammation involves administering aspirin and other non-steroidal anti-inflammatory agents to relieve pain and fever.
    • The systemic response to local inflammation is known as the acute-phase response, characterized by fever, increased hormone synthesis, white blood cell production, and acute-phase protein production in the liver.

    Chronic Inflammation

    • Chronic inflammation occurs when the inflammation becomes the problem rather than the solution to infection, injury, or disease.
    • Chronic inflammation can break down healthy tissue in a misdirected attempt at repair and healing.
    • Diseases characterized by chronic inflammation include Crohn's, Lupus, Psoriasis, Diabetes, Coronary artery disease, Rheumatoid arthritis, Asthma, Solid organ transplant rejection, Chronic Bronchitis, Cancer.
    • Chronic inflammation increases the risk of developing many types of cancer.

    Wound Healing

    • Wound healing is the replacement of destroyed or damaged tissue with newly produced tissue.
    • The stages of wound healing include hemostasis (blood clotting), inflammation (clearing damaged cells and pathogens), and proliferation and remodeling.

    Pyrogens

    • Pyrogens are molecules released by macrophages exposed to bacteria, which travel to the hypothalamus and trigger fever, creating an unfavorable environment for bacterial growth.
    • Fever causes the spleen and liver to remove iron from the blood, which is required by many bacteria to reproduce, and increases metabolism, facilitating healing and phagocytosis.

    Interferons

    • Interferons are small proteins released from cells infected by viruses, which bind to receptors on uninfected cells, triggering the synthesis of enzymes that inhibit viral replication.
    • Interferons do not protect cells already infected by a virus but rather stop the spread of the virus to new cells.

    Inflammatory Response

    • Acute inflammation typically lasts only a few days and is a beneficial process that serves to immobilize the area of injury as the rest of the immune system mobilizes to heal.
    • The inflammatory response is characterized by erythema (redness), edema (swelling), heat, and pain at the site of injury.
    • The response is triggered by a set of mediators, including histamine and prostaglandins.
    • After injury, arterioles constrict to limit bleeding and then dilate to increase blood flow, providing the area with essential immune cells, nutrients, and oxygen.

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    Description

    This quiz covers the treatment of acute inflammation, including the administration of aspirin and other non-steroidal anti-inflammatory agents, and the systemic response following local inflammation.

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