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Questions and Answers
What is the main requirement for active tubular secretion?
What is the main requirement for active tubular secretion?
- Passive diffusion
- Dependence on renal blood flow
- Energy for transportation of compounds with the concentration gradient
- Carrier-mediated process (correct)
Which compounds are secreted through the system for organic acids/anions?
Which compounds are secreted through the system for organic acids/anions?
- Uric acid and morphine
- Glucuronides and sulphates (correct)
- Salts and sugars
- Catecholamines and choline
What is the renal clearance value for penicillin, indicating its active secretion?
What is the renal clearance value for penicillin, indicating its active secretion?
- 500 ml/min (correct)
- 200 ml/min
- 700 ml/min
- 130 ml/min
How are drugs undergoing active secretion affected by changes in pH and protein binding?
How are drugs undergoing active secretion affected by changes in pH and protein binding?
What is unique about the system for secretion of organic bases/cations?
What is unique about the system for secretion of organic bases/cations?
What is the primary location where active secretion occurs in the nephron?
What is the primary location where active secretion occurs in the nephron?
How does a drug with greater rate of clearance affect the excretion of another drug with which it competes?
How does a drug with greater rate of clearance affect the excretion of another drug with which it competes?
What is the therapeutic effect of probenecid on organic acids such as penicillins?
What is the therapeutic effect of probenecid on organic acids such as penicillins?
Why is inhibition of drug secretion by probenecid undesirable in the case of nitrofurantoin?
Why is inhibition of drug secretion by probenecid undesirable in the case of nitrofurantoin?
What is cimetidine known for being a competitive inhibitor of?
What is cimetidine known for being a competitive inhibitor of?
