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Active Tubular Secretion Mechanisms Quiz

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Active Tubular Secretion Mechanisms Quiz

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Questions and Answers

What is the main requirement for active tubular secretion?

Passive diffusion

Dependence on renal blood flow

Energy for transportation of compounds with the concentration gradient

Carrier-mediated process (correct)

Which compounds are secreted through the system for organic acids/anions?

Uric acid and morphine

Glucuronides and sulphates (correct)

Salts and sugars

Catecholamines and choline

What is the renal clearance value for penicillin, indicating its active secretion?

500 ml/min (correct)

200 ml/min

700 ml/min

130 ml/min

How are drugs undergoing active secretion affected by changes in pH and protein binding?

They are unaffected Signup and view all the answers

What is unique about the system for secretion of organic bases/cations?

It can be bidirectional, i.e. agents may both be secreted as well as reabsorbed actively Signup and view all the answers

What is the primary location where active secretion occurs in the nephron?

Proximal tubule Signup and view all the answers

How does a drug with greater rate of clearance affect the excretion of another drug with which it competes?

It retards the excretion of the other drug Signup and view all the answers

What is the therapeutic effect of probenecid on organic acids such as penicillins?

It increases their concentration in plasma by at least two fold Signup and view all the answers

Why is inhibition of drug secretion by probenecid undesirable in the case of nitrofurantoin?

Nitrofurantoin is used as a urinary tract antiseptic Signup and view all the answers

What is cimetidine known for being a competitive inhibitor of?

Organic cation transport Signup and view all the answers