Acid Proteases Quiz

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Questions and Answers

Which protease is the most active among the cysteine proteases mentioned in the text?

  • Cathepsin D
  • Cathepsin S
  • Cathepsin L (correct)
  • Cathepsin B

Which protease is important for processing the tetanus toxin antigen for MHC class II presentation?

  • Cathepsin B
  • Cathepsin S
  • Asparagine endopeptidase (AEP) (correct)
  • Cathepsin D

Which protease is not required in all cases where antigen processing is involved?

  • Asparagine endopeptidase (AEP) (correct)
  • Cathepsin B
  • Cathepsin S
  • Cathepsin D

Which protease deficiency leads to deficiencies in cross-presentation?

<p>Cathepsin S (A)</p> Signup and view all the answers

Which drug inhibits the presentation of intravesicular antigens by raising the pH of endosomes?

<p>Chloroquine (A)</p> Signup and view all the answers

Which type of T cells recognize peptides bound to MHC class I molecules?

<p>CD8 T cells (C)</p> Signup and view all the answers

Which type of T cells recognize peptides bound to MHC class II molecules?

<p>CD4 T cells (A)</p> Signup and view all the answers

Which cells express MHC class I molecules?

<p>Somatic cells (A)</p> Signup and view all the answers

What is the primary function of CD8 T cells?

<p>Pathogen surveillance and cytolysis of somatic cells (A)</p> Signup and view all the answers

What is another name for CD8 T cells?

<p>Cytotoxic T cells (D)</p> Signup and view all the answers

Which type of T cells are primarily responsible for pathogen surveillance and cytolysis of somatic cells?

<p>CD8 T cells (A)</p> Signup and view all the answers

Which type of T cells recognize peptides bound to MHC class II molecules?

<p>CD4 T cells (C)</p> Signup and view all the answers

Which cells express MHC class I molecules?

<p>All somatic cells except red blood cells (C)</p> Signup and view all the answers

What is the pattern of recognition determined by in the binding of CD8 or CD4 molecules to the respective MHC molecules?

<p>Specific binding of CD8 or CD4 molecules to MHC class I or class II molecules (B)</p> Signup and view all the answers

What are the two distinct purposes of the processing and presentation of pathogen-derived antigens?

<p>Inducing the development of armed effector T cells and triggering the effector functions of these armed cells at sites of infection (C)</p> Signup and view all the answers

Which cellular compartment is responsible for the translocation of MHC class II molecules during their biosynthetic pathway?

<p>Endoplasmic reticulum (A)</p> Signup and view all the answers

What is the role of the MHC class II-associated invariant chain (Ii, CD74) in the biosynthesis of MHC class II molecules?

<p>Prevent premature peptide binding (D)</p> Signup and view all the answers

Where does the amino terminus of the MHC class II-associated invariant chain (Ii, CD74) reside?

<p>Cytosol (B)</p> Signup and view all the answers

What is the role of the MHC class II-associated invariant chain (Ii, CD74) in preventing premature peptide binding?

<p>It binds to the MHC class II molecule's peptide-binding groove (A)</p> Signup and view all the answers

Which cellular compartment contains unfolded and partly folded polypeptide chains that need to be prevented from binding to MHC class II molecules?

<p>Endoplasmic reticulum (A)</p> Signup and view all the answers

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