Achondroplasia vs Thanatophoric Dysplasia Quiz

Play an AI-generated podcast conversation about this lesson

What radiographic finding is typically seen on films taken after 7-14 days of tuberculous osteomyelitis?

Involucrum

Lucent gap in the bone cortex

Subperiosteal new bone formation (correct)

Sequestrum

Which area of the body is commonly involved in Pott's disease?

Wrist

Hip

Vertebrae (correct)

Elbow

In tuberculous osteomyelitis, what can be seen in chronic/untreated cases as a result of bone destruction?

Cloaca

Periosteal elevation

Involucrum

Sequestrum (correct)

What is a rare but significant complication of advanced cases of tuberculous osteomyelitis involving the joint?

Cutaneous sinuses Signup and view all the answers

Which of the following is NOT a common site for skeletal syphilis?

Knee Signup and view all the answers

At what stage of gestation do bone lesions typically begin to appear in congenital syphilis?

5th month Signup and view all the answers

What is the typical clinical presentation of pyogenic osteomyelitis?

Gradual onset of symptoms over several days, dull pain, tenderness, swelling, fever & rigors Signup and view all the answers

How is the diagnosis of acute pyogenic osteomyelitis usually confirmed?

Typical clinical & radiographic findings together with persistently inflammatory markers in the absence of positive culture and no biopsy interpretation Signup and view all the answers

What percentage of cases with pyogenic osteomyelitis have positive blood cultures?

50-60% Signup and view all the answers

Which imaging modality is considered to have high sensitivity and negative predictive value for detecting osteomyelitis?

MRI Signup and view all the answers

In which part of the bone are kids affected by osteomyelitis?

Metaphysis Signup and view all the answers

What is a common feature of chondroblastoma?

Osteoclast-like giant cells mixed with chondroblasts Signup and view all the answers

What is characteristic radiographic finding indicating osteomyelitis in adults?

Bone destruction of proximal phalanges Signup and view all the answers

Which primary malignant bone tumor is the second most common?

Chondrosarcoma Signup and view all the answers

What feature gives chondrosarcoma its glistening, gray-blue appearance?

Neoplastic cells producing a chondroid matrix Signup and view all the answers

What is a characteristic prognosis feature of chondrosarcomas?

Tumors >10 cm are more aggressive Signup and view all the answers

In which age group is giant-cell tumor most commonly found?

Young adults in their 20s-40s Signup and view all the answers

How are conventional chondrosarcomas typically treated?

Wide surgical excision Signup and view all the answers

Which skeletal abnormality is typically associated with Achondroplasia?

Short extremities and underdeveloped thoracic cavity Signup and view all the answers

What is a common cause of death in infants with Thanatophoric dysplasia?

Respiratory insufficiency Signup and view all the answers

Which disease is associated with defects in extracellular structural proteins and manifests as 'Brittle bone disease'?

Osteogenesis Imperfecta Signup and view all the answers

Which type of Osteogenesis Imperfecta has normal life span but childhood fractures that decrease after puberty?

Type I Signup and view all the answers

What is a common symptom of Osteogenesis Imperfecta related to teeth?

Opalescent hue of teeth Signup and view all the answers

Which disease results in osteopenia with marked cortical thinning and trabecular rarefaction, along with susceptibility to fractures?

Osteogenesis Imperfecta Signup and view all the answers

What type of tumor is described as soft, lobulated, gelatinous, and composed of vacuolated cells in a sea of mucoid material?

Chordoma Signup and view all the answers

In which region of the body do benign fibrohistiocytic tumors like Non-Ossifying Fibroma (NOF) commonly arise in skeletally immature individuals?

Metaphysis of long bones Signup and view all the answers

What is the characteristic radiographic appearance of Non-Ossifying Fibromas (NOF)?

Sharp demarcated radiolucencies surrounded by a thin rim of sclerosis Signup and view all the answers

Which malignancies are responsible for more than 75% of skeletal metastases in adults?

Prostate, breast, kidney, thyroid, lung cancers Signup and view all the answers

Which area of the body is NOT commonly affected by metastatic bone disease?

Radial bone Signup and view all the answers

What facilitates the implantation and growth of tumor cells leading to the common locations of metastatic bone disease?

Red marrow in long bones Signup and view all the answers