30 Questions
Match the triptan medication with its primary route of administration:
Sumatriptan = Nasal sprays Naratriptan = Conventional tablet Rizatriptan = Disintegrating tablet Zolmitriptan = Injections
Match the following effects with the use of triptans:
Vasoconstriction = Reduction of migraine symptoms Reduce inflammation = Nausea and vomiting relief Pain transmission reduction = Contraindicated in patients with ischemic heart disease Increased blood pressure = Drowsiness and muscle pain
Match the following triptan medication with its primary usage:
Almotriptan = First-line treatment of moderate to severe migraine pain Eletriptan = Useful for patients experiencing nausea and vomiting Frovatriptan = Achieves best results with early use Sumatriptan = Interactions possible with St. John’s wort
Match the following adverse reactions with the use of triptans:
Drowsiness = Zolmitriptan Sweating = Almotriptan Anxiety = Eletriptan Muscle pain = Naratriptan
Match the following triptan medication with its primary effect onset time:
Sumatriptan = 20 to 60 minutes Naratriptan = 2 to 4 hours Rizatriptan = Within 20 minutes Zolmitriptan = No specific onset time
Match the following triptan medication with its contraindication:
Sumatriptan = Ischemic heart disease Naratriptan = St. John’s wort interactions Rizatriptan = Muscle pain Zolmitriptan = Nausea and vomiting
Match the following medications with their primary usage in managing headaches:
Ergotamine preparations = Abortive therapy for migraines Triptans = Initial pharmacotherapy for acute treatment of migraine NSAIDs, antispasmodic agents, and neuroleptics = Nonspecific medications for migraines Beta-blockers, antiepileptics, antidepressants, ACE inhibitors, CGRP monoclonal antibodies = Prophylactic treatment of migraines
Match the following nonpharmacologic options with their usage in managing cluster headaches:
100% oxygen, subcutaneous sumatriptan, intranasal zolmitriptan = Medical management Occipital and vagal nerve stimulation = Nonpharmacologic options
Match the following treatments with their usage in managing cranial arteritis:
Early corticosteroid administration = Preventing vision loss Not stopping medication abruptly = Patient instructions
Match the following medications with their primary usage in managing tension-type headaches:
Acetaminophen, aspirin, nonsteroidal anti-inflammatory agents = Medication for acute therapy Rest, relaxation techniques, stress reduction strategies = Nonpharmacologic methods
Match the following medications with their primary usage in managing acute menstrual migraines:
Nonsteroidal anti-inflammatory agents, acetaminophen–aspirin with caffeine, ergot alkaloids, triptans = Initial abortive therapy Caffeine = Effective analgesic adjuvant
Match the following medications with their primary usage in managing cluster headaches:
100% oxygen, subcutaneous sumatriptan, intranasal zolmitriptan = Medical management Occipital and vagal nerve stimulation = Nonpharmacologic options
Match the medication with its patient teaching guidelines:
Acetaminophen–aspirin–caffeine combinations = Dosage limits, avoiding other medications with acetaminophen, and keeping the medication away from children Ergotamine = Specific dosage information for different groups, preventing interactions with alpha 1 agonists and CYP3A4 inhibitors, and being cautious with medications and foods that interact with ergotamine
Match the medication with its usage for migraine headaches:
Acetaminophen–aspirin–caffeine combinations = Not used for migraine headaches Ergotamine = Administered to prevent or stop migraine, cluster, or vascular headaches and is less effective than triptans
Match the medication with its adverse effects:
Acetaminophen–aspirin–caffeine combinations = Not specified in the given text Ergotamine = Cardiovascular and musculoskeletal effects, as well as other side effects like vertigo and nausea
Match the contraindications with the medication:
Acetaminophen–aspirin–caffeine combinations = Not specified in the given text Ergotamine = Hypersensitivity, peripheral vascular disease, and certain medications that inhibit CYP3A4, pregnancy, lactation, and in the presence of certain diseases like hepatic and renal disease
Match the medication with its peak of action and half-life:
Acetaminophen–aspirin–caffeine combinations = Not specified in the given text Ergotamine = Peak of action at 0.5 to 3 hours and a half-life of 2 hours
Match the medication with its method of administration:
Acetaminophen–aspirin–caffeine combinations = Not specified in the given text Ergotamine = Sublingual administration, and the tablet should be dissolved under the tongue without drinking, eating, or smoking during the process
Match the drug with its primary usage in migraine treatment:
Naproxen Sodium = Rapid absorption and analgesic effects Botulinum toxin type A = Small decrease in number of headaches per month Tricyclic drugs = Reverse central sensitization and chronicity of headaches Ketorolac tromethamine = Frequently administered intravenously in emergency settings for migraine treatment
Match the drug with its adverse effects in migraine treatment:
Naproxen Sodium = Bronchospasm, anaphylaxis, and gastrointestinal bleeding Botulinum toxin type A = No severe adverse effects reported Tricyclic drugs = Not associated with severe adverse effects Ketorolac tromethamine = Potential for gastrointestinal bleeding and kidney damage
Match the drug with its contraindications in migraine treatment:
Naproxen Sodium = Known allergy to aspirin, pregnancy, and lactation Botulinum toxin type A = No specific contraindications reported Tricyclic drugs = Caution in patients with cardiac conduction disorders and glaucoma Ketorolac tromethamine = Contraindicated in patients with active peptic ulcer disease and recent gastrointestinal bleeding
Match the drug with its metabolism and excretion in migraine treatment:
Naproxen Sodium = Metabolized in the liver, half-life of 12-15 hours, excreted in urine Botulinum toxin type A = Not metabolized, excreted unchanged in urine Tricyclic drugs = Metabolized in the liver, excreted in urine and feces Ketorolac tromethamine = Metabolized in the liver, excreted in urine
Match the drug with its mechanism of action in migraine treatment:
Naproxen Sodium = Nonselective inhibitor of cyclooxygenase, inhibiting prostaglandin synthesis of COX-1 and COX-2 Botulinum toxin type A = Blocks the release of acetylcholine at the neuromuscular junction Tricyclic drugs = Inhibits the reuptake of serotonin and norepinephrine in the central nervous system Ketorolac tromethamine = Inhibits the synthesis of prostaglandins, resulting in decreased formation of inflammatory mediators
Match the drug with its interactions in migraine treatment:
Naproxen Sodium = Increases lithium levels and the risk of toxicity when taken with lithium Botulinum toxin type A = No significant drug interactions reported Tricyclic drugs = Interacts with a wide range of medications, including SSRIs and antihypertensives Ketorolac tromethamine = Potential interactions with anticoagulants and other NSAIDs
Match the medication component with its primary effect:
Acetaminophen = Acts as an analgesic Aspirin = Inhibits prostaglandin synthesis Caffeine = Causes vascular constriction
Match the medication component with its specific effect on the combination medication:
Caffeine = Enhances the effectiveness of acetaminophen and aspirin by 40% Acetaminophen = Used to reduce pain related to migraine or tension headaches Aspirin = Causes GI effects
Match the age group or condition with the appropriate usage caution for the combination medication:
Children over 12 = May receive the adult dose Children with hepatic impairment = Should not use the combination on an ongoing basis Pregnancy = Caution is advised Lactation = Caution is advised
Match the adverse effect with the corresponding medication component:
Hepatic impairment = Acetaminophen GI effects = Aspirin Excitement and cardiovascular effects = Caffeine Allergic reactions = Acetaminophen
Match the drug interaction with its specific effect on the combination medication:
Oral anticoagulants = Increased hypoprothrombinemic effects Sulfonylureas and insulin = Greater glucose-lowering effects Caffeine and guarana, ma huang, and ephedra = Concomitant administration not recommended Other drugs = Effects on hepatotoxicity, bleeding risk, and central nervous system effects
Match the assessment task with the corresponding aspect of the combination medication:
Monitoring for diminished pain using a pain scale = Assessing therapeutic effects Assessing for hepatotoxicity, allergic reactions, fluid and electrolyte imbalance, hypoglycemia, agitation, and cardiovascular effects = Assessing adverse effects Preventing interactions with other drugs = Maintaining medication safety Familiarity with the medication = Nurses' responsibility
Study Notes
Acetaminophen-Aspirin-Caffeine Combination Medication: Key Points
- Acetaminophen acts as an analgesic, while aspirin inhibits prostaglandin synthesis and caffeine increases calcium permeability.
- Caffeine causes vascular constriction and enhances the effectiveness of acetaminophen and aspirin by 40%.
- The combination medication is used to reduce pain related to migraine or tension headaches.
- Children over 12 may receive the adult dose, but those with hepatic impairment should not use the combination on an ongoing basis.
- Adverse effects of the components include hepatic impairment from acetaminophen, GI effects from aspirin, and excitement and cardiovascular effects from caffeine.
- Contraindications include known allergies to the drugs and caution is advised for hepatic impairment, pregnancy, and lactation.
- Nurses should be familiar with the medication and prevent interactions with other drugs to maintain medication safety.
- Drug interactions with the combination medication include effects on hepatotoxicity, bleeding risk, and central nervous system effects.
- Specific drug interactions involve increased hypoprothrombinemic effects with oral anticoagulants and greater glucose-lowering effects with sulfonylureas and insulin.
- Assessing therapeutic effects involves monitoring for diminished pain using a pain scale after administration of the combination medication.
- Nurses should also assess for adverse effects such as hepatotoxicity, allergic reactions, fluid and electrolyte imbalance, hypoglycemia, agitation, and cardiovascular effects.
- The concomitant administration of caffeine and guarana, ma huang, and ephedra is not recommended.
Test your knowledge of the acetaminophen-aspirin-caffeine combination medication with this quiz. Explore key points such as therapeutic effects, adverse reactions, drug interactions, and nursing considerations related to this commonly used pain relief medication.
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