Questions and Answers
What drug class is acamprosate in?
Psychiatry Agents/ GABA analog
What are the contraindications of acamprosate?
Renal impairment, suicidality and depression, alcohol withdrawal, pregnancy, geriatric and pediatric use
What drug-drug interactions are associated with acamprosate?
Naltrexone increases acamprosate levels
What is the mechanism of action of acamprosate?
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What are the therapeutic effects of acamprosate?
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What are the side effects of acamprosate?
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What are the adverse reactions of acamprosate?
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Study Notes
Acamprosate Overview
- Acamprosate belongs to the drug class of Psychiatry Agents and is classified as a GABA analog.
- Its primary therapeutic effect is to assist individuals in stopping alcohol consumption.
Contraindications
- Acamprosate is contraindicated in patients with renal impairment, as it may exacerbate conditions related to kidney function.
- Individuals with a history of suicidality and depression should avoid this medication due to increased risks.
- Use during alcohol withdrawal is not recommended.
- Not advised for use in pregnant women, geriatric patients, or pediatric populations.
Drug-Drug Interactions
- Naltrexone, a medication used in the treatment of alcohol dependence, can increase the levels of acamprosate in the body.
Mechanism of Action
- Acamprosate works by modulating glutamate activity at NMDA receptors, which is crucial for promoting abstinence from alcohol.
Common Side Effects
- Possible side effects include:
- Pain and nausea
- Loss of appetite and diarrhea
- Dizziness and anxiety
- Pruritus (itchiness) and depression
- Insomnia, xerostomia (dry mouth), and paresthesia (tingling sensation)
Adverse Reactions
- Signs of allergic reactions can occur in some patients.
- There is an elevated risk of suicidal thoughts or behaviors among users, especially those with a prior history of such issues.
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Description
This quiz covers the essential information about Acamprosate, including its therapeutic use in treating alcohol dependence and its mechanism of action as a GABA analog. Learn about contraindications, potential drug interactions, and common side effects associated with this medication.
