Podcast
Questions and Answers
Which drug is used for the relief of dysmenorrhea and has a tocolytic effect by inhibiting prostaglandin synthesis?
Which drug is used for the relief of dysmenorrhea and has a tocolytic effect by inhibiting prostaglandin synthesis?
- Nitric oxide donors
- Magnesium sulfate
- Indomethacin (correct)
- Progesterone
What is the main adverse effect associated with NSAIDs like indomethacin when used as tocolytics?
What is the main adverse effect associated with NSAIDs like indomethacin when used as tocolytics?
- Premature closure of ductus arteriosus (correct)
- Cervical ripening
- Myocardial depression
- Maternal hypertension
Which drug is given by IV infusion, has a depressant action on uterine smooth muscle, and is used to control convulsions and blood pressure in toxemia of pregnancy?
Which drug is given by IV infusion, has a depressant action on uterine smooth muscle, and is used to control convulsions and blood pressure in toxemia of pregnancy?
- Magnesium sulfate (correct)
- Nitric oxide donors
- Indomethacin
- Progesterone
Which hormone has relaxant effects on the uterus, inhibits cytokine production, and is used in the treatment of threatened abortion?
Which hormone has relaxant effects on the uterus, inhibits cytokine production, and is used in the treatment of threatened abortion?
Which drug acts by inhibiting the influx of Ca$^{2+}$ into myometrial cells?
Which drug acts by inhibiting the influx of Ca$^{2+}$ into myometrial cells?
Which of the following drugs competitively blocks the oxytocin receptors of the uterus?
Which of the following drugs competitively blocks the oxytocin receptors of the uterus?
Which condition is a contraindication for the use of selective $eta_2$-agonists as uterine relaxants?
Which condition is a contraindication for the use of selective $eta_2$-agonists as uterine relaxants?
Which drug may cause cardiovascular collapse if it escapes into circulation after intra-amniotic injection?
Which drug may cause cardiovascular collapse if it escapes into circulation after intra-amniotic injection?
Why is oxytocin preferred for induction of labor?
Why is oxytocin preferred for induction of labor?
In postpartum hemorrhage, why is oxytocin preferred over methyl-ergometrine?
In postpartum hemorrhage, why is oxytocin preferred over methyl-ergometrine?
Which type of drug is oxytocin in obstetrics and gynecology?
Which type of drug is oxytocin in obstetrics and gynecology?
What role does oxytocin play in maintaining placental blood flow during labor?
What role does oxytocin play in maintaining placental blood flow during labor?
Flashcards
Indomethacin's tocolytic effect
Indomethacin's tocolytic effect
Indomethacin inhibits prostaglandin synthesis, reducing uterine contractions.
NSAID tocolytic adverse effect
NSAID tocolytic adverse effect
Premature closure of the ductus arteriosus is a major risk of using NSAIDs to stop labor.
Magnesium sulfate in pregnancy
Magnesium sulfate in pregnancy
Magnesium sulfate controls convulsions and blood pressure in toxemia of pregnancy.
Progesterone's role in pregnancy
Progesterone's role in pregnancy
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Nifedipine's mechanism
Nifedipine's mechanism
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Atosiban's action
Atosiban's action
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Contraindication for eta2-agonists
Contraindication for eta2-agonists
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Intra-amniotic Dinoprostone risk
Intra-amniotic Dinoprostone risk
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Oxytocin's labor induction preference
Oxytocin's labor induction preference
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Oxytocin vs. methyl-ergometrine in postpartum
Oxytocin vs. methyl-ergometrine in postpartum
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Oxytocin's role in obstetrics and gynecology
Oxytocin's role in obstetrics and gynecology
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Oxytocin's effect on placental blood flow
Oxytocin's effect on placental blood flow
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Study Notes
Dysmenorrhea and Tocolytics
- Indomethacin is used for dysmenorrhea relief and exhibits a tocolytic effect by inhibiting prostaglandin synthesis.
- The main adverse effect of NSAIDs like indomethacin when used as tocolytics is potential risk of premature closure of the ductus arteriosus in the fetus.
Uterine Smooth Muscle Effects
- Magnesium sulfate is administered via IV infusion, acting as a depressant on uterine smooth muscle, controlling convulsions and blood pressure during toxemia of pregnancy.
- The hormone relaxin induces relaxant effects on the uterus, inhibits cytokine production, and is applied in the treatment of threatened abortion.
Mechanisms of Action
- Calcium channel blockers, such as nifedipine, inhibit the influx of Ca$^{2+}$ into myometrial cells to provide uterine relaxation.
- Antagonists to oxytocin competitively block oxytocin receptors in the uterus, preventing premature contractions.
Contraindications and Risks
- Selective $eta_2$-agonists as uterine relaxants are contraindicated in patients with cardiovascular issues due to the risk of adverse effects.
- If a drug escapes into circulation after intra-amniotic injection, it may lead to severe cardiovascular collapse.
Induction of Labor and Postpartum Hemorrhage
- Oxytocin is preferred for labor induction as it effectively stimulates uterine contractions while maintaining fetal welfare.
- During postpartum hemorrhage, oxytocin is favored over methyl-ergometrine due to a safer profile and reduced side effects.
Oxytocin in Obstetrics and Gynecology
- Oxytocin serves as a crucial drug in obstetrics and gynecology for its roles in stimulating labor and managing postpartum hemorrhage.
- It plays a significant role in maintaining placental blood flow during labor by promoting coordinated contractions and reducing excessive bleeding.
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Description
Test your knowledge on drugs used as abortifacients and uterine relaxants, including their side effects and administration methods. Learn about common side effects like uterine pain, nausea, and vomiting, as well as the risks associated with intra-amniotic injections. Explore different tocolytics that inhibit uterine contractions.
