ABO Blood Group System
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Questions and Answers

What is immunogenicity a measure of?

  • The ability of an antigen to provoke an immune response (correct)
  • The degree of polymorphism of an antigen
  • The accessibility of an antigen to immune cells
  • The molecular characteristics of an antigen
  • Which type of antibodies is directed against carbohydrate/glycolipid antigens?

  • IgM (correct)
  • IgE
  • IgG
  • IgA
  • What is the result of IgG and IgM red cell antibodies reacting with specific antigens on the red cell surface?

  • Haemolysis of the red cell in vivo (correct)
  • Haemagglutination in vitro
  • Production of more antibodies
  • No reaction occurs
  • How many different antigens have been found on red cell membranes?

    <p>Over 400</p> Signup and view all the answers

    Which Blood Group System is classified as a Major Blood Group System?

    <p>All of the above</p> Signup and view all the answers

    What is the function of IgG antibodies?

    <p>Direct against protein/glycoprotein antigens</p> Signup and view all the answers

    What is the result of exposure to ‘foreign’ immunogenic Red Cell Antigens?

    <p>Humoral Immune Response</p> Signup and view all the answers

    What is the chromosome location of the MNS Blood Group System?

    <p>4</p> Signup and view all the answers

    What is the clinical significance of IgG and IgM red cell antibodies?

    <p>They cause haemolysis of the red cell in vivo</p> Signup and view all the answers

    What is composed of proteins, e.g. in red cell membrane antigenic structures?

    <p>Proteins</p> Signup and view all the answers

    What is the resulting reaction when an individual lacking either the A or B antigens on their red cells is exposed to the corresponding antigen?

    <p>A fatal haemolytic transfusion reaction</p> Signup and view all the answers

    Which of the following is a function of the RhD and RhCE polypeptides?

    <p>To form a macrocomplex with Rh Associated Glycoprotein and other large membrane macromolecules</p> Signup and view all the answers

    What is the primary function of the DARC glycoprotein in the Duffy Blood Group System?

    <p>To act as a receptor for Chemokines</p> Signup and view all the answers

    What is the term for the process of determining the blood type of an individual by incubating their red cells with antibodies of known specificity?

    <p>Blood Group Typing</p> Signup and view all the answers

    What is the term for the reaction observed when antibodies of known specificity bind to specific antigens on the red cell surface?

    <p>Haemagglutination</p> Signup and view all the answers

    Which of the following is NOT a component of the Rh polypeptide complex?

    <p>Glycophorin A</p> Signup and view all the answers

    What is the term for the antigenic structures found on glycophorin A and glycophorin B in the MNS blood group system?

    <p>M and N antigens</p> Signup and view all the answers

    What is the purpose of incubating unknown test red cells with unknown test serum from six 'colleagues' in the Laboratory Practical?

    <p>To determine the ABO blood group of each sample</p> Signup and view all the answers

    What is the type of technique used in the Laboratory Practical to determine the ABO blood group of each sample?

    <p>Direct Saline Haemagglutination</p> Signup and view all the answers

    What is the term for a substance that can elicit an immune response and react specifically with the product of that response?

    <p>Antigen</p> Signup and view all the answers

    What is the term for the site on an antigen that an antibody binds to?

    <p>Epitope</p> Signup and view all the answers

    What is the purpose of blood phenotyping in blood bank practice?

    <p>To determine the compatibility of donor and recipient blood</p> Signup and view all the answers

    What is the term for the production of antibodies by the immune system in response to the presence of an antigen?

    <p>Humoral response</p> Signup and view all the answers

    What is the term for the membrane structure of a red blood cell that contains glycocalyx, lipid bilayer, and cytoskeleton?

    <p>Red cell membrane</p> Signup and view all the answers

    What is the term for the specific immune response to a foreign antigen?

    <p>Normal humoral response</p> Signup and view all the answers

    What is the process of testing for the presence of specific antibodies in a person's blood?

    <p>Haemagglutination testing</p> Signup and view all the answers

    What is the term for a system of antigens present on the surface of red blood cells?

    <p>Blood group antigen system</p> Signup and view all the answers

    What is the purpose of antigen-antibody reactions in transfusion science?

    <p>To determine the compatibility of donor and recipient blood</p> Signup and view all the answers

    What is the term for the structure that makes up the outer layer of a red blood cell?

    <p>Glycocalyx</p> Signup and view all the answers

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