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Questions and Answers
What is the main difference between Thalassaemias and Hemoglobinopathies?
What is the main difference between Thalassaemias and Hemoglobinopathies?
- Thalassaemias result in an imbalance in alpha to beta chain ratio, while Hemoglobinopathies result in excessive fetal hemoglobin production.
- Thalassaemias are genetic disorders, while Hemoglobinopathies are acquired disorders.
- Thalassaemias cause changes in amino acid sequences of globin chain, while Hemoglobinopathies lead to reduced hemoglobin synthesis.
- Thalassaemias involve a reduced rate of globin chain synthesis, while Hemoglobinopathies involve structural abnormalities in the globin chain. (correct)
Which group of disorders is characterized by the persistent elevation of fetal hemoglobin in adulthood?
Which group of disorders is characterized by the persistent elevation of fetal hemoglobin in adulthood?
- Sickle cell anemia
- Hemoglobinopathies
- Hereditary persistant fetal hemoglobin (correct)
- Thalassaemias
How is the inheritance pattern of Alpha Thalassaemia described?
How is the inheritance pattern of Alpha Thalassaemia described?
- X-linked recessive
- Mitochondrial inheritance
- Autosomal recessive (correct)
- Autosomal dominant
Which region widely experiences the distribution of Alpha Thalassaemia?
Which region widely experiences the distribution of Alpha Thalassaemia?
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What is the primary cause of severity in Alpha Thalassaemia?
What is the primary cause of severity in Alpha Thalassaemia?
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At what age does the normal switch of hemoglobin from HbF to HbA occur?
At what age does the normal switch of hemoglobin from HbF to HbA occur?
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