Abnormalities of Hemoglobin Disorders Quiz
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Questions and Answers

What is the main difference between Thalassaemias and Hemoglobinopathies?

  • Thalassaemias result in an imbalance in alpha to beta chain ratio, while Hemoglobinopathies result in excessive fetal hemoglobin production.
  • Thalassaemias are genetic disorders, while Hemoglobinopathies are acquired disorders.
  • Thalassaemias cause changes in amino acid sequences of globin chain, while Hemoglobinopathies lead to reduced hemoglobin synthesis.
  • Thalassaemias involve a reduced rate of globin chain synthesis, while Hemoglobinopathies involve structural abnormalities in the globin chain. (correct)
  • Which group of disorders is characterized by the persistent elevation of fetal hemoglobin in adulthood?

  • Sickle cell anemia
  • Hemoglobinopathies
  • Hereditary persistant fetal hemoglobin (correct)
  • Thalassaemias
  • How is the inheritance pattern of Alpha Thalassaemia described?

  • X-linked recessive
  • Mitochondrial inheritance
  • Autosomal recessive (correct)
  • Autosomal dominant
  • Which region widely experiences the distribution of Alpha Thalassaemia?

    <p>Africa</p> Signup and view all the answers

    What is the primary cause of severity in Alpha Thalassaemia?

    <p>Gene deletion affecting the production of alpha chains</p> Signup and view all the answers

    At what age does the normal switch of hemoglobin from HbF to HbA occur?

    <p>6 months</p> Signup and view all the answers

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