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Questions and Answers
What is the viscosity of Ethyl Cellulose?
20 cP
What is the pH range of the finished product?
3-6
How should the finished product be stored?
In a dry, ventilated, clean warehouse, away from heat sources, and direct sunlight
What is the function of Ethyl Cellulose in solid dose forms?
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What are the other names of Ethyl Cellulose?
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What is the CAS number of Ethyl Cellulose?
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What is the molecular formula of Ethyl Cellulose?
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What is the density of Ethyl Cellulose at 25°C?
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What is the trade name of Ethyl Cellulose?
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What is the spontaneous combustion temperature of Ethyl Cellulose?
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Study Notes
Push-Pull Osmotic Pumps (PPOP)
- Bilayered tablet coated with semi-permeable membrane coating
- Delivers drugs with extremes of water solubility
- Upper compartment: drug + osmogents
- Lower compartment: polymeric osmotic agents
- Drug release: polymeric osmotic layer swells, pushes drug as fine dispersion via delivery orifice
Sandwiched Osmotic Tablet Systems (SOTS)
- Composed of polymeric push layer sandwiched between two drug layers with two delivery orifices
- Suitable for drugs prone to cause local irritation of the gastric mucosa
- Drug release: middle push layer containing the swelling agent swells, drug is released from two delivery orifices
Oral Osmotic Capsules
- OROS CT system: designed for colon targeted drug delivery
- Single osmotic unit or multiple push-pull units enclosed within a hard gelatin capsule
Formulation Factors Affecting Drug Release
- Solubility of the active ingredient: affects kinetics of osmotic drug release
- Equation: F(z) = 1 − $\frac{s}{\rho}$
- Drugs with solubility < 0.05 g/cm3: released with > 95% zero-order kinetics
- Highly water-soluble drugs: high release rate, but zero-order for a small percentage of initial drug load
Osmotic Pressure
- Dependent on number of discrete entities of solute present in the solution
- Water permeability of CA films: decreases with increasing plasticizer concentration, then increases
Diameter of Delivery Orifice
- Must be optimized to control drug release from osmotic systems
- Small orifice size: affects zero-order release, may lead to deformation of the delivery system
Eplerenone
- Mechanism: binds to mineralocorticoid receptors, antagonizing aldosterone
- Pharmacokinetics: absorption, distribution, metabolism, and elimination
- Bioavailability: 7%
- Mean peak plasma concentrations: reached approximately 1.5 hours following oral administration
- Metabolism: via cytochrome P450 (CYP) 3A4 pathway
Ethyl Cellulose
- Hydrophobic cellulose ether used as a coating material, tablet binder, and matrix former
- Membrane is not swellable, compatible with most plasticizers and pore-forming substances
- Chemical structure, trade names, viscosity, and solubility
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Description
Learn about the push-pull osmotic pump, a bilayered tablet used for delivering drugs with varying water solubility. The device consists of an upper compartment containing the drug and osmogents, connected to a lower compartment with polymeric osmotic agents, allowing controlled drug release.
