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Questions and Answers
What is the viscosity of Ethyl Cellulose?
What is the viscosity of Ethyl Cellulose?
20 cP
What is the pH range of the finished product?
What is the pH range of the finished product?
3-6
How should the finished product be stored?
How should the finished product be stored?
In a dry, ventilated, clean warehouse, away from heat sources, and direct sunlight
What is the function of Ethyl Cellulose in solid dose forms?
What is the function of Ethyl Cellulose in solid dose forms?
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What are the other names of Ethyl Cellulose?
What are the other names of Ethyl Cellulose?
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What is the CAS number of Ethyl Cellulose?
What is the CAS number of Ethyl Cellulose?
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What is the molecular formula of Ethyl Cellulose?
What is the molecular formula of Ethyl Cellulose?
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What is the density of Ethyl Cellulose at 25°C?
What is the density of Ethyl Cellulose at 25°C?
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What is the trade name of Ethyl Cellulose?
What is the trade name of Ethyl Cellulose?
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What is the spontaneous combustion temperature of Ethyl Cellulose?
What is the spontaneous combustion temperature of Ethyl Cellulose?
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Study Notes
Push-Pull Osmotic Pumps (PPOP)
- Bilayered tablet coated with semi-permeable membrane coating
- Delivers drugs with extremes of water solubility
- Upper compartment: drug + osmogents
- Lower compartment: polymeric osmotic agents
- Drug release: polymeric osmotic layer swells, pushes drug as fine dispersion via delivery orifice
Sandwiched Osmotic Tablet Systems (SOTS)
- Composed of polymeric push layer sandwiched between two drug layers with two delivery orifices
- Suitable for drugs prone to cause local irritation of the gastric mucosa
- Drug release: middle push layer containing the swelling agent swells, drug is released from two delivery orifices
Oral Osmotic Capsules
- OROS CT system: designed for colon targeted drug delivery
- Single osmotic unit or multiple push-pull units enclosed within a hard gelatin capsule
Formulation Factors Affecting Drug Release
- Solubility of the active ingredient: affects kinetics of osmotic drug release
- Equation: F(z) = 1 − $\frac{s}{\rho}$
- Drugs with solubility < 0.05 g/cm3: released with > 95% zero-order kinetics
- Highly water-soluble drugs: high release rate, but zero-order for a small percentage of initial drug load
Osmotic Pressure
- Dependent on number of discrete entities of solute present in the solution
- Water permeability of CA films: decreases with increasing plasticizer concentration, then increases
Diameter of Delivery Orifice
- Must be optimized to control drug release from osmotic systems
- Small orifice size: affects zero-order release, may lead to deformation of the delivery system
Eplerenone
- Mechanism: binds to mineralocorticoid receptors, antagonizing aldosterone
- Pharmacokinetics: absorption, distribution, metabolism, and elimination
- Bioavailability: 7%
- Mean peak plasma concentrations: reached approximately 1.5 hours following oral administration
- Metabolism: via cytochrome P450 (CYP) 3A4 pathway
Ethyl Cellulose
- Hydrophobic cellulose ether used as a coating material, tablet binder, and matrix former
- Membrane is not swellable, compatible with most plasticizers and pore-forming substances
- Chemical structure, trade names, viscosity, and solubility
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Description
Learn about the push-pull osmotic pump, a bilayered tablet used for delivering drugs with varying water solubility. The device consists of an upper compartment containing the drug and osmogents, connected to a lower compartment with polymeric osmotic agents, allowing controlled drug release.
