term 2- lec 1
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Questions and Answers

What is true about Lamins:

  • . Contain a nuclear localization signal (NLS) to be imported into the nucleus
  • . They are components of the nuclear lamina
  • They are intermediate filament proteins
  • . They are mutated the premature aging disease Hutchinson-Gilford progeria syndrome or all of the above (correct)

  • Phosphorylation:

  • Consists of the addition of a phosphate group to an aminoacid (commonly serine, threonine or tyrosine) or a lipid (correct)
  • Is the removal of phosphate groups from aminoacids or lipids
  • Is the addition of phosphatases to aminoacids or lipids
  • Always results in the termination of a signal

How does cell division differ between prokaryotes and eukaryotes?

  • It does not differ
  • Prokaryotes undergo meiosis for the production of gametes and mitosis for other dividing cell
  • Eukaryotes undergo meiosis for the production of gametes and mitosis for other dividing cells, prokaryotes divide with binary fission.
  • Eukaryotes undergo meiosis for the production of gametes and mitosis for other dividing cells. (correct)

How is the cell cycle coordinated?

<p>all of the above (D)</p> Signup and view all the answers

How are cyclins activated and deactivated?

<p>all of the above (D)</p> Signup and view all the answers

What Cyclin/Cdk combinations are active at the different stages of the cell cycle?

<p>GoG1: Cyclin D-CDK4/6; S: Cyclin A/CDK2; G2: Cyclin A/CDK1; M: Cyclin B/Cdk1 (A)</p> Signup and view all the answers

  • The G1 checkpoint:

<p>Is regulated by Rb, which is a tumour suppressor. Rb binds E2F and prevents gene transcription. (A)</p> Signup and view all the answers

The G1 checkpoint:

<p>All of the above (D)</p> Signup and view all the answers

  • Mitosis consists of

<p>Prophase, Metaphase, telophase and anaphase. (B)</p> Signup and view all the answers

What is the name of a key phosphatase that dephosphorylates an inhibitory phosphate

<p>Cdc25 (C)</p> Signup and view all the answers

  • The S-phase checkpoint

<p>is a surveillance mechanism, that responds to DNA damage and replication perturbations, and is mediated by ATR and Chk2 in human cells. (B)</p> Signup and view all the answers

The spindle checkpoint

<p>Detects the lack of microtubule attachment to chromosomes then releasing MAD-2, inhibiting the destruction of Cyclin B and MPF inactivation (B)</p> Signup and view all the answers

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