12 Questions
What is true about Lamins:
. They are mutated the premature aging disease Hutchinson-Gilford progeria syndrome or all of the above
- Phosphorylation:
Consists of the addition of a phosphate group to an aminoacid (commonly serine, threonine or tyrosine) or a lipid
How does cell division differ between prokaryotes and eukaryotes?
Eukaryotes undergo meiosis for the production of gametes and mitosis for other dividing cells.
How is the cell cycle coordinated?
all of the above
How are cyclins activated and deactivated?
all of the above
What Cyclin/Cdk combinations are active at the different stages of the cell cycle?
GoG1: Cyclin D-CDK4/6; S: Cyclin A/CDK2; G2: Cyclin A/CDK1; M: Cyclin B/Cdk1
- The G1 checkpoint:
Is regulated by Rb, which is a tumour suppressor. Rb binds E2F and prevents gene transcription.
The G1 checkpoint:
All of the above
- Mitosis consists of
Prophase, Metaphase, telophase and anaphase.
What is the name of a key phosphatase that dephosphorylates an inhibitory phosphate
Cdc25
- The S-phase checkpoint
is a surveillance mechanism, that responds to DNA damage and replication perturbations, and is mediated by ATR and Chk2 in human cells.
The spindle checkpoint
Detects the lack of microtubule attachment to chromosomes then releasing MAD-2, inhibiting the destruction of Cyclin B and MPF inactivation
Test your knowledge on cell division processes, differences between prokaryotes and eukaryotes, cell cycle coordination, activation and deactivation of cyclins, and active Cyclin/Cdk combinations at different stages of the cell cycle.
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