Podcast
Questions and Answers
What is metabolism?
What is metabolism?
All chemical reactions that maintain the living state of cells and organisms.
What is anabolism?
What is anabolism?
Assimilation of molecules and complex structures from the building blocks of life. This also requires energy.
What is catabolism?
What is catabolism?
Breakdown of molecules to obtain the anabolic 'building blocks' of life and substrates for energy. It is a precursor for the anabolic process.
What is the role of glucose in ATP production?
What is the role of glucose in ATP production?
What is the role of glucose in the provision of building blocks for synthetic glucose?
What is the role of glucose in the provision of building blocks for synthetic glucose?
How is glucose transported into the cells?
How is glucose transported into the cells?
What is glycolysis? What is the net ATP gain per glucose molecule?
What is glycolysis? What is the net ATP gain per glucose molecule?
What is the pathway for the metabolism of glucose?
What is the pathway for the metabolism of glucose?
What are the control points in glycolysis?
What are the control points in glycolysis?
How do control points affect the rate of reaction in glycolysis?
How do control points affect the rate of reaction in glycolysis?
What are the enzymes catalysing irreversible reactions?
What are the enzymes catalysing irreversible reactions?
What is the role of fructokinase in control points of glycolysis?
What is the role of fructokinase in control points of glycolysis?
What activates and inhibits fructokinase in glycolysis control points?
What activates and inhibits fructokinase in glycolysis control points?
What is the role of pyruvate kinase in glycolysis control points?
What is the role of pyruvate kinase in glycolysis control points?
What is the role of hexokinase in glycolysis control points?
What is the role of hexokinase in glycolysis control points?
What is the role of fructokinase in the glycolysis control points?
What is the role of fructokinase in the glycolysis control points?
What is the role of pyruvate following glycolysis?
What is the role of pyruvate following glycolysis?
What is the role of the NADH following glycolysis?
What is the role of the NADH following glycolysis?
What is the process of anaerobic metabolism in terms of pyruvate conversion?
What is the process of anaerobic metabolism in terms of pyruvate conversion?
What is the Warburg effect?
What is the Warburg effect?
What are the properties of the Warburg effect in terms of energy production, growth and end products?
What are the properties of the Warburg effect in terms of energy production, growth and end products?
What is the result of cancer cells possessing a low Km hexokinase enzyme?
What is the result of cancer cells possessing a low Km hexokinase enzyme?
How can we treat cancer through the steps of glycolysis?
How can we treat cancer through the steps of glycolysis?
Why is the NAD+ regeneration required in metabolism?
Why is the NAD+ regeneration required in metabolism?
Where does the Krebs (TCA) cycle occur?
Where does the Krebs (TCA) cycle occur?
How does pyruvate enter the mitochondrial matrix?
How does pyruvate enter the mitochondrial matrix?
How is pyruvate metabolised into Acetyl-CoA?
How is pyruvate metabolised into Acetyl-CoA?
What is the process of the Krebs (TCA) cycle?
What is the process of the Krebs (TCA) cycle?
What is the catalyst for the first step of the Krebs cycle (Acetyl CoA --> CoA-SH)?
What is the catalyst for the first step of the Krebs cycle (Acetyl CoA --> CoA-SH)?
What is the primary objective of the Krebs cycle?
What is the primary objective of the Krebs cycle?
What are the products of the Krebs cycle?
What are the products of the Krebs cycle?
Where are the enzymes of the Krebs cycle located?
Where are the enzymes of the Krebs cycle located?
What are the regulation control points in the citric acid cycle?
What are the regulation control points in the citric acid cycle?
What is the role of citrate synthase in the regulation of the citric acid cycle? What is it inhibited by?
What is the role of citrate synthase in the regulation of the citric acid cycle? What is it inhibited by?
What is the role of is-citrate dehydrogenase in the regulation of the Krebs cycle? What is it inhibited by?
What is the role of is-citrate dehydrogenase in the regulation of the Krebs cycle? What is it inhibited by?
What is the role of alpha ketoglutarate dehydrogenase in the regulation of the Krebs cycle?
What is the role of alpha ketoglutarate dehydrogenase in the regulation of the Krebs cycle?