52 Questions
Match the terms
Chapter 795 = regulations from USP-NF for compounding nonsterile preparations Chapter 797 = regulations from USP-NF for compounding sterile preparations Chapter 800 = regulations from USP-NF for compounding sterile and nonsterile hazardous drug preparations Compounding Record = a record of what actually happened when the preparation was compounded
Match the terms
Formulation Record = formulas and procedures (recipes) for what should happen when a preparation is compounded aliquot = a portion of a mixture arrest knob = the knob on a balance that prevents any movement of the balance pans calibrate = to set, mark, or check the graduations of a measuring device
Match the terms
volumetric = measures volume; either TD or TC meniscus = the curved surface of a column of liquid geometric dilution = a technique for mixing two powders of unequal quantity spatulation = mixing powders with a spatula
Match the terms
trituration = the process of grinding powders to reduce particle size levigation = triturating a powder with a solvent in which it is insoluble to reduce its particle size flocculating agent = electrolytes used in the preparation of suspensions to form particles that can be easily redispersed levigating agent = a liquid that will not dissolve a solid drug, but will "wet" the solid drug's particles
Match the terms
thickening agent = an ingredient used in the preparation of suspensions to increase the viscosity of the liquid emulsifer = a stabilizing agent in emulsions hydrophilic emulsifer = a stabilizing agent for water based dispersion mediums immiscible = cannot be mixed
Match the terms
lipophilic emulsifer = a stabilizing agent for oil based dispersion mediums mucilage = a wet, slimy liquid formed as an initial step in Wet Gum method oil-in-water emulsion = an emulsion in which oil is dispersed in a water base primary emulsion = the initial emulsion to which ingredients are added to create the final product
Match the terms
water-in-oil emuslion = an emulsion in which water is dispersed in an oil base drug delivery vehicle = specialized system designed to transport drugs or medications to a specific target within the body miscible = capable of being mixed together stability = the extent to which a dosage form retains the properties and characteristics as when it was prepared
Match the terms
compression molding = a method of making suppositories in which the ingredients are compressed in a mold fusion molding = a suppository preparation method in which the active ingredients are dispersed or dissolved in a melted suppository base and poured into a mold finger cots = protective coverings for fingers punch method = a method for filling capsules by repeatedly pushing, or "punching" the capsule into an amount of drug powder
Compounding is the on-demand formulation of a drug preparation according to a physician's prescription for
an individual patient
The documentation that provides the actual ingredients and procedures used to compound a preparation is the
Compounding Record
Which is the correct statement when weighing a powder on a Class III torsion balance?
USe a clean weigh boat with each new powder
A 100 mL graduated cylinder cannot accurately measure volumes less than
15 mL
If a 5 mL liquid volume needs to be measured, a ______ should be used.
10 mL oral syringe
________ is the term for triturating a powder with a solvent in which it is insoluble to reduce its particle size.
Levigation
The fine grinding of a powder is called
trituration
Elixirs, tinctures, and liniments are examples of
nonaqueous solutions
An aqueous solution of water-soluble ingredients is added to an alcoholic solution of alcohol-soluble ingredients and the resulting solution turns cloudy or "milky." What is happening?
The alcoholic components are coming out of the solution
Most patients want their flavor experience (i.e., the flavoring in liquid preparations) to have
acceptable mouth feel
If you need to compound a liquid preparation containing a water-based vehicle and an active drug that is an oil, the appropriate dosage form would be a/an
emulsion
When making a lotion using the Beaker method, the internal phase is slowly added to the external phase. This is done so that the
the external phase will not invert to the internal phase
Which suppository base would be preferable for vaginal suppositories?
Glycerinated gelatin
Capsules can contain
all of the above
The dose of a powder to be placed in a capsule is 325 mg and the powder has a density similar to aspirin. What would be the appropriate size of a hard gelatin capsule to use?
size 1
A technician has prepared a liquid solution of diphenhydramine in cottonseed oil (50 mg/mL) to place in capsules. The patient is to receive a 25 mg dose. What would be an appropriate size capsule to use
size 1
A formulation record for an effervescent powder shows the base is made of: Sodium bicarbonate 52.4% Tartaric acid 28.6% Citric acid, monohydrate 19.0%
If the total amount of base to be prepared is 160 grams, what amount of each powder will need to be weighed?
83.8, 45.7, 30.4 grams
A technician is going to batch bacitracin and lidocaine in sodium chloride syringes using an automatic fluid transfer device (a repeater pump). Each syringe is to contain 25 mL of solution, and 1250 mL of solution has been prepared. How many syringes should be filled in this batch?
50
An active drug has its solubility given as "soluble" in a reference book. If you are going to make a solution by dissolving 6 grams of the active drug in water, how much water will you need to make the solution?
60-180g
A brand of wild cherry syrup you have in your pharmacy has 2% alcohol in it. If you are going to dispense 30 mL of the syrup, how many mL of alcohol will be in the dispensed preparation?
.60
Which activity would be considered compounding?
Making a 3% hydrocortisone ointment for a patient
Compounders of nonsterile preparations must be knowledgeable about chapter 795. Which individual would not be considered a compounder?
Physiologist
A compounded cream shows that the emulsion has broken after 35 days. So a conservative ________ date would be 30 days.
beyond-use
Which statement is not true about any balance used in prescription compounding?
it must have a sensitivity requirement of 6 mg or less
Which would not be a proper method for measuring a specific volume of liquid?
Measure the volume of liquid in a graduated cylinder reading the top of the meniscus
Which technique will not reduce the particle size of a powder?
geometric dilution
Which characteristics indicate a good suspension
settles slowly and redisperses quickly
Which differentiates a solution from a suspension or emulsion?
the drug is a molecular dispersion in a solution
What do emulsions and ointments have in common?
both have a primary emulsion as the basis of their preparations
Which carbohydrate is often used as a bulk filler in molded tablet triturates?
lactose
Establishes standards of quality, strength, purity, packaging, and labeling for compounded medications
USP-NF
The storage temperature definition for a freezer is
-20 C to -10 C
The minimum weighable quantity for a class III balance is
120 mg
Mertic weights used for weighing ingredients using a class III balance should be handled with
forceps
Quantities less than 120 mg may be measured using a/an
aliquot
The application of sound waves to affect dissolution is
sonication
An appropriate flavoring for a metallic tasting drugs is
mint
______ are electrolytes used in the preparation of suspensions
flocculating agents
A two-phase system consisting of a finely divided solid dispersed in a liquid is a/an
suspension
_______ are thickening agents used in the preparation of suspensions
suspending agents
______ is less sweet than sucrose
sorbitol
The punch method is used to prepare
capsules
Polyethylene glycol (PEG) polymers are used to make _______ suppositories
water-soluble or miscible
_______ are mixtures of oleaginous and water-miscible bases for making suppositories
hydrophilic bases
Test your knowledge by matching the given terms in this quiz. Challenge yourself and see how many correct matches you can make!
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