Nonsterile Compounding

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Match the terms

Chapter 795 = regulations from USP-NF for compounding nonsterile preparations Chapter 797 = regulations from USP-NF for compounding sterile preparations Chapter 800 = regulations from USP-NF for compounding sterile and nonsterile hazardous drug preparations Compounding Record = a record of what actually happened when the preparation was compounded

Match the terms

Formulation Record = formulas and procedures (recipes) for what should happen when a preparation is compounded aliquot = a portion of a mixture arrest knob = the knob on a balance that prevents any movement of the balance pans calibrate = to set, mark, or check the graduations of a measuring device

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volumetric = measures volume; either TD or TC meniscus = the curved surface of a column of liquid geometric dilution = a technique for mixing two powders of unequal quantity spatulation = mixing powders with a spatula

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trituration = the process of grinding powders to reduce particle size levigation = triturating a powder with a solvent in which it is insoluble to reduce its particle size flocculating agent = electrolytes used in the preparation of suspensions to form particles that can be easily redispersed levigating agent = a liquid that will not dissolve a solid drug, but will "wet" the solid drug's particles Signup and view all the answers

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thickening agent = an ingredient used in the preparation of suspensions to increase the viscosity of the liquid emulsifer = a stabilizing agent in emulsions hydrophilic emulsifer = a stabilizing agent for water based dispersion mediums immiscible = cannot be mixed Signup and view all the answers

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lipophilic emulsifer = a stabilizing agent for oil based dispersion mediums mucilage = a wet, slimy liquid formed as an initial step in Wet Gum method oil-in-water emulsion = an emulsion in which oil is dispersed in a water base primary emulsion = the initial emulsion to which ingredients are added to create the final product Signup and view all the answers

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water-in-oil emuslion = an emulsion in which water is dispersed in an oil base drug delivery vehicle = specialized system designed to transport drugs or medications to a specific target within the body miscible = capable of being mixed together stability = the extent to which a dosage form retains the properties and characteristics as when it was prepared Signup and view all the answers

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compression molding = a method of making suppositories in which the ingredients are compressed in a mold fusion molding = a suppository preparation method in which the active ingredients are dispersed or dissolved in a melted suppository base and poured into a mold finger cots = protective coverings for fingers punch method = a method for filling capsules by repeatedly pushing, or "punching" the capsule into an amount of drug powder Signup and view all the answers

Compounding is the on-demand formulation of a drug preparation according to a physician's prescription for

an individual patient Signup and view all the answers

The documentation that provides the actual ingredients and procedures used to compound a preparation is the

Compounding Record Signup and view all the answers

Which is the correct statement when weighing a powder on a Class III torsion balance?

USe a clean weigh boat with each new powder Signup and view all the answers

A 100 mL graduated cylinder cannot accurately measure volumes less than

15 mL Signup and view all the answers

If a 5 mL liquid volume needs to be measured, a ______ should be used.

10 mL oral syringe Signup and view all the answers

________ is the term for triturating a powder with a solvent in which it is insoluble to reduce its particle size.

Levigation Signup and view all the answers

The fine grinding of a powder is called

trituration Signup and view all the answers

Elixirs, tinctures, and liniments are examples of

nonaqueous solutions Signup and view all the answers

An aqueous solution of water-soluble ingredients is added to an alcoholic solution of alcohol-soluble ingredients and the resulting solution turns cloudy or "milky." What is happening?

The alcoholic components are coming out of the solution Signup and view all the answers

Most patients want their flavor experience (i.e., the flavoring in liquid preparations) to have

acceptable mouth feel Signup and view all the answers

If you need to compound a liquid preparation containing a water-based vehicle and an active drug that is an oil, the appropriate dosage form would be a/an

emulsion Signup and view all the answers

When making a lotion using the Beaker method, the internal phase is slowly added to the external phase. This is done so that the

the external phase will not invert to the internal phase Signup and view all the answers

Which suppository base would be preferable for vaginal suppositories?

Glycerinated gelatin Signup and view all the answers

Capsules can contain

all of the above Signup and view all the answers

The dose of a powder to be placed in a capsule is 325 mg and the powder has a density similar to aspirin. What would be the appropriate size of a hard gelatin capsule to use?

size 1 Signup and view all the answers

A technician has prepared a liquid solution of diphenhydramine in cottonseed oil (50 mg/mL) to place in capsules. The patient is to receive a 25 mg dose. What would be an appropriate size capsule to use

size 1 Signup and view all the answers

A formulation record for an effervescent powder shows the base is made of: Sodium bicarbonate 52.4% Tartaric acid 28.6% Citric acid, monohydrate 19.0%

If the total amount of base to be prepared is 160 grams, what amount of each powder will need to be weighed?

83.8, 45.7, 30.4 grams Signup and view all the answers

A technician is going to batch bacitracin and lidocaine in sodium chloride syringes using an automatic fluid transfer device (a repeater pump). Each syringe is to contain 25 mL of solution, and 1250 mL of solution has been prepared. How many syringes should be filled in this batch?

50 Signup and view all the answers

An active drug has its solubility given as "soluble" in a reference book. If you are going to make a solution by dissolving 6 grams of the active drug in water, how much water will you need to make the solution?

60-180g Signup and view all the answers

A brand of wild cherry syrup you have in your pharmacy has 2% alcohol in it. If you are going to dispense 30 mL of the syrup, how many mL of alcohol will be in the dispensed preparation?

.60 Signup and view all the answers

Which activity would be considered compounding?

Making a 3% hydrocortisone ointment for a patient Signup and view all the answers

Compounders of nonsterile preparations must be knowledgeable about chapter 795. Which individual would not be considered a compounder?

Physiologist Signup and view all the answers

A compounded cream shows that the emulsion has broken after 35 days. So a conservative ________ date would be 30 days.

beyond-use Signup and view all the answers

Which statement is not true about any balance used in prescription compounding?

it must have a sensitivity requirement of 6 mg or less Signup and view all the answers

Which would not be a proper method for measuring a specific volume of liquid?

Measure the volume of liquid in a graduated cylinder reading the top of the meniscus Signup and view all the answers

Which technique will not reduce the particle size of a powder?

geometric dilution Signup and view all the answers

Which characteristics indicate a good suspension

settles slowly and redisperses quickly Signup and view all the answers

Which differentiates a solution from a suspension or emulsion?

the drug is a molecular dispersion in a solution Signup and view all the answers

What do emulsions and ointments have in common?

both have a primary emulsion as the basis of their preparations Signup and view all the answers

Which carbohydrate is often used as a bulk filler in molded tablet triturates?

lactose Signup and view all the answers

Establishes standards of quality, strength, purity, packaging, and labeling for compounded medications

USP-NF Signup and view all the answers

The storage temperature definition for a freezer is

-20 C to -10 C Signup and view all the answers

The minimum weighable quantity for a class III balance is

120 mg Signup and view all the answers

Mertic weights used for weighing ingredients using a class III balance should be handled with

forceps Signup and view all the answers

Quantities less than 120 mg may be measured using a/an

aliquot Signup and view all the answers

The application of sound waves to affect dissolution is

sonication Signup and view all the answers

An appropriate flavoring for a metallic tasting drugs is

mint Signup and view all the answers

______ are electrolytes used in the preparation of suspensions

flocculating agents Signup and view all the answers

A two-phase system consisting of a finely divided solid dispersed in a liquid is a/an

suspension Signup and view all the answers

_______ are thickening agents used in the preparation of suspensions

suspending agents Signup and view all the answers

______ is less sweet than sucrose

sorbitol Signup and view all the answers

The punch method is used to prepare

capsules Signup and view all the answers

Polyethylene glycol (PEG) polymers are used to make _______ suppositories

water-soluble or miscible Signup and view all the answers

_______ are mixtures of oleaginous and water-miscible bases for making suppositories

hydrophilic bases Signup and view all the answers

Nonsterile Compounding - CH 9

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Questions and Answers

Match the terms

Match the terms

Match the terms

Match the terms

Match the terms

Match the terms

Match the terms

Match the terms

Compounding is the on-demand formulation of a drug preparation according to a physician's prescription for

The documentation that provides the actual ingredients and procedures used to compound a preparation is the

Which is the correct statement when weighing a powder on a Class III torsion balance?

A 100 mL graduated cylinder cannot accurately measure volumes less than

If a 5 mL liquid volume needs to be measured, a ______ should be used.

________ is the term for triturating a powder with a solvent in which it is insoluble to reduce its particle size.

The fine grinding of a powder is called

Elixirs, tinctures, and liniments are examples of

An aqueous solution of water-soluble ingredients is added to an alcoholic solution of alcohol-soluble ingredients and the resulting solution turns cloudy or "milky." What is happening?

Most patients want their flavor experience (i.e., the flavoring in liquid preparations) to have

If you need to compound a liquid preparation containing a water-based vehicle and an active drug that is an oil, the appropriate dosage form would be a/an

When making a lotion using the Beaker method, the internal phase is slowly added to the external phase. This is done so that the

Which suppository base would be preferable for vaginal suppositories?

Capsules can contain

The dose of a powder to be placed in a capsule is 325 mg and the powder has a density similar to aspirin. What would be the appropriate size of a hard gelatin capsule to use?

A technician has prepared a liquid solution of diphenhydramine in cottonseed oil (50 mg/mL) to place in capsules. The patient is to receive a 25 mg dose. What would be an appropriate size capsule to use

A formulation record for an effervescent powder shows the base is made of: Sodium bicarbonate 52.4% Tartaric acid 28.6% Citric acid, monohydrate 19.0% If the total amount of base to be prepared is 160 grams, what amount of each powder will need to be weighed?

A technician is going to batch bacitracin and lidocaine in sodium chloride syringes using an automatic fluid transfer device (a repeater pump). Each syringe is to contain 25 mL of solution, and 1250 mL of solution has been prepared. How many syringes should be filled in this batch?

An active drug has its solubility given as "soluble" in a reference book. If you are going to make a solution by dissolving 6 grams of the active drug in water, how much water will you need to make the solution?

A brand of wild cherry syrup you have in your pharmacy has 2% alcohol in it. If you are going to dispense 30 mL of the syrup, how many mL of alcohol will be in the dispensed preparation?

Which activity would be considered compounding?

Compounders of nonsterile preparations must be knowledgeable about chapter 795. Which individual would not be considered a compounder?

A compounded cream shows that the emulsion has broken after 35 days. So a conservative ________ date would be 30 days.

Which statement is not true about any balance used in prescription compounding?

Which would not be a proper method for measuring a specific volume of liquid?

Which technique will not reduce the particle size of a powder?

Which characteristics indicate a good suspension

Which differentiates a solution from a suspension or emulsion?

What do emulsions and ointments have in common?

Which carbohydrate is often used as a bulk filler in molded tablet triturates?

Establishes standards of quality, strength, purity, packaging, and labeling for compounded medications

The storage temperature definition for a freezer is

The minimum weighable quantity for a class III balance is

Mertic weights used for weighing ingredients using a class III balance should be handled with

Quantities less than 120 mg may be measured using a/an

The application of sound waves to affect dissolution is

An appropriate flavoring for a metallic tasting drugs is

______ are electrolytes used in the preparation of suspensions

A two-phase system consisting of a finely divided solid dispersed in a liquid is a/an

_______ are thickening agents used in the preparation of suspensions

______ is less sweet than sucrose

The punch method is used to prepare

Polyethylene glycol (PEG) polymers are used to make _______ suppositories

_______ are mixtures of oleaginous and water-miscible bases for making suppositories

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A formulation record for an effervescent powder shows the base is made of: Sodium bicarbonate 52.4% Tartaric acid 28.6% Citric acid, monohydrate 19.0%

If the total amount of base to be prepared is 160 grams, what amount of each powder will need to be weighed?