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Questions and Answers

What is the primary purpose of using a Controlled Internal Drug Release (CIDR) in postpartum cows?

  • To reduce calving intervals
  • To improve feed conversion efficiency
  • To synchronize estrus and improve reproductive performance (correct)
  • To enhance milk production

Which of the following is NOT considered a potential outcome of cystic ovarian follicles?

  • Increased ovulation frequency (correct)
  • Turnover
  • Luteinization
  • Regression

What is one of the primary factors leading to the development of follicular cysts in cows?

  • Insufficient follicular turnover
  • Excessive body condition score
  • High circulating glucose levels
  • Absence of LH pre-ovulatory surge (correct)

How is the prevalence of cystic ovarian follicles described in dairy cows?

<p>High, at around 10% annually (D)</p> Signup and view all the answers

What effect does a low progesterone (P4) level environment have on oocyte viability?

<p>Decreases oocyte viability (C)</p> Signup and view all the answers

Which statement about the follicular cysts is accurate?

<p>They may be single or multiple structures. (A)</p> Signup and view all the answers

What commonly leads to decreased sensitivity of the hypothalamus to estrogen (E2) in cows?

<p>Decreased levels of circulating IGF-1 (D)</p> Signup and view all the answers

What is the role of biosecurity in an appropriate herd health program?

<p>Preventing the introduction of disease into the herd (A)</p> Signup and view all the answers

Which type of ovarian cyst does NOT respond to GnRH for luteinization?

<p>Non-dominant cysts (A)</p> Signup and view all the answers

What is one of the characteristics of cows with ovarian cysts?

<p>Prolonged estrus in nymphomania cases (B)</p> Signup and view all the answers

What is the role of progesterone (P4) in the treatment of ovarian cysts?

<p>Decreases pulsatile secretion of LH (B)</p> Signup and view all the answers

During the diagnosis of ovarian cysts, which method offers a 90% accuracy in differentiating between follicular and luteal cysts?

<p>Ultrasound examination (C)</p> Signup and view all the answers

What is the primary objective of treating ovarian cysts?

<p>Increase secretion of P4 after treatment (B)</p> Signup and view all the answers

What factor impacts the pulsatile secretion of LH in the context of cystic ovarian disease?

<p>Progesterone produced by the cyst (B)</p> Signup and view all the answers

What thickness in the cyst wall is indicative of a luteal cyst during ultrasound examination?

<p>3mm or greater (A)</p> Signup and view all the answers

What is the most common congenital defect of the bovine reproductive system?

<p>FM (B)</p> Signup and view all the answers

Which factor directly contributes to delaying cyclicity in high-yielding dairy herds?

<p>High production of milk (D)</p> Signup and view all the answers

What is a common misdiagnosis related to ovarian cysts noted in the context of transrectal examination?

<p>Large functional CL mistaken as cysts (B)</p> Signup and view all the answers

What is a direct consequence of negative energy balance on reproductive hormone release?

<p>Decreased GnRH release (A)</p> Signup and view all the answers

Which condition does NOT contribute to anestrus in heifers?

<p>Overnutrition (D)</p> Signup and view all the answers

How does the presence of a calf affect reproductive hormone secretion?

<p>It inhibits GnRH and LH secretion (C)</p> Signup and view all the answers

Which of the following is associated with the postpartum period's first follicular wave emergence?

<p>Increase in FSH levels (C)</p> Signup and view all the answers

What is a recommended method to prevent and control postpartum anestrus?

<p>Implementing a nutritional plan based on milk yield (B)</p> Signup and view all the answers

Which of the following problems is most likely caused by metabolic diseases in heifers?

<p>Reduced ovulation frequency (B)</p> Signup and view all the answers

What is a characteristic feature of Freemartinism?

<p>Increased ano-genital area and enlarged clitoris (C)</p> Signup and view all the answers

Which condition is associated with the term 'White Heifers Disease'?

<p>Segmental aplasia of the Müllerian ducts (B)</p> Signup and view all the answers

What is the most distinguishing feature of Incomplete Fusion of the Müllerian Ducts?

<p>Presence of double external cervical os (D)</p> Signup and view all the answers

What diagnostic procedure can be used to identify blood cells containing Y chromosomes in Freemartinism?

<p>PCR (A)</p> Signup and view all the answers

What is the primary cause of difficulty in passing an AI pipette in patients with Incomplete Fusion of the Müllerian Ducts?

<p>Presence of multiple cervical os (A)</p> Signup and view all the answers

What is the likely reproductive tract status in congenital bilateral ovarian hypoplasia?

<p>Underdeveloped reproductive tract (C)</p> Signup and view all the answers

What condition can be misdiagnosed as pregnancy due to similar symptoms?

<p>Hydrometra (A)</p> Signup and view all the answers

What represents a common misconception about the diagnosis of Segmental Aplasia of the Müllerian Ducts?

<p>Misdiagnosis can occur due to symptoms resembling other conditions. (D)</p> Signup and view all the answers

What is the primary cause of Freemartinism in cattle?

<p>Fusion of the chorio-allantoic portions of twin placentas (C)</p> Signup and view all the answers

Which hormone is responsible for inhibiting the development of the Müllerian ducts in female fetuses during Freemartinism?

<p>Antimüllerian hormone (AMH) (A)</p> Signup and view all the answers

Which of the following describes a common clinical finding in Freemartin calves?

<p>Small vulva and hypoplastic ovaries (D)</p> Signup and view all the answers

How does the presence of two cell types in a freemartin calf occur?

<p>Via exchange of humoral and cellular elements between twin fetuses (D)</p> Signup and view all the answers

What mechanism leads to the abnormal development of the reproductive tract in Freemartin calves?

<p>Delayed ovarian development after testicular formation (A)</p> Signup and view all the answers

What is a typical diagnostic tool used to assess the internal reproductive tract of a Freemartin calf?

<p>Ultrasound or palpation (B)</p> Signup and view all the answers

What is the gestational age range when the fusion of chorio-allantoic portions of twin placentas typically occurs in Freemartinism?

<p>28-30 days post conception (B)</p> Signup and view all the answers

Which best describes the chromosomal makeup of a Freemartin calf?

<p>A typical 60 chromosomes, possibly with a combination of male and female (B)</p> Signup and view all the answers

Flashcards

Chromosomal Sex

The genetic makeup of an individual, determined by the presence of sex chromosomes (XX for female, XY for male).

Gonadal Sex

The development of the gonads (testes or ovaries) based on the chromosomal sex.

Phenotypic Sex

The physical characteristics of an individual that correspond to their sex, including external genitalia and secondary sex characteristics.

Freemartinism

A condition in female cattle twins where the female calf is infertile due to exposure to male hormones (AMH) from the male twin.

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Antimüllerian Hormone (AMH)

Hormone produced by the testes of a male fetus that inhibits the development of the female reproductive tract.

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Mullerian Ducts

Structures in the female fetus that develop into the fallopian tubes, uterus, and cervix.

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Wolffian Ducts

Structures in the male fetus that develop into the epididymis, vas deferens, and seminal vesicles.

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Chimera

An individual that contains cells from two different zygotes (fertilized eggs).

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Segmental Aplasia of the Müllerian Ducts

A developmental condition where portions of the female reproductive tract (vagina, cervix, uterus, oviducts) fail to develop properly due to genetic mutation.

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Hydrometra

A condition where fluid accumulates in the uterus due to blockage, often caused by malformations like the absence of a cervix.

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Uterus Unicornis

A condition where one horn of the uterus is absent, leaving a single functional horn.

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Uterus Didelphys

A condition where the uterus is incompletely fused, resulting in two separate uterine horns and two cervical openings, often due to autosomal dominant inheritance.

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Incomplete Fusion of Müllerian Ducts

A condition where the Müllerian ducts fail to completely fuse, resulting in abnormalities like a double cervix, which can affect fertility and delivery.

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Ovarian Hypoplasia

A congenital condition where one or both ovaries are underdeveloped, leading to reduced fertility or complete sterility.

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Atrophy by Nutritional Deficiency

A condition where the ovaries shrink and lose function due to lack of proper nutrients.

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Acyclicity

The absence of regular estrous cycles in a female animal, meaning she doesn't cycle regularly and is unable to become pregnant.

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Subfertility

Reduced fertility, meaning a female animal has difficulty getting pregnant or carrying a pregnancy to term.

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Congenital Defects

Physical abnormalities present at birth that can affect fertility in female cows, such as a malformed reproductive tract.

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Anestrus

The absence of estrous cycles in a cow, meaning she doesn't show signs of heat or ovulate.

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Postpartum Anestrus

The absence of estrous cycles in a cow after calving, often due to factors like high milk production, poor nutrition, or stress.

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Negative Energy Balance

A state where a cow is consuming less energy than she's expending, which can lead to anestrus and other health problems.

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Factors that contribute to postpartum anestrus:

Factors like high milk production, poor nutrition, stress, infections, and the presence of a calf can all disrupt a cow's cycle after calving.

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Cystic Ovarian Follicles

Anovulatory follicles that persist for a long time, larger than normal follicles, and often over 2.0 cm in diameter. They lack a functional corpus luteum and are prevalent in about 10% of dairy cows annually.

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Prolonged Intercalving Interval

A longer than normal period between calving events, potentially caused by cystic ovarian follicles or other issues.

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Follicular Persistency

A condition where a dominant follicle persists for an extended period without ovulating, leading to high levels of estrogen and inhibin.

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LH Pre-ovulatory Surge

The surge in luteinizing hormone (LH) that triggers ovulation. In follicular cysts, this surge is absent or insufficient.

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Decreased Sensitivity to Estrogen

Hypothalamic-pituitary axis has reduced sensitivity to estrogen feedback, leading to a lack of ovulation.

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Follicular Cyst Formation

The formation of a fluid-filled sac in the ovary, typically thin-walled and consisting of single or multiple structures.

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Bull Effect

Improved reproductive performance in cows after exposure to a bull, likely due to changes in hormonal profiles and behavioral responses.

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CIDR (Controlled Internal Drug Release)

A device used to release progestins in cows to synchronize estrus and improve reproductive efficiency.

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Luteal Cyst

A cyst formed from a follicle where some granulosa cells luteinize, but E2 levels remain low.

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Follicular Cyst

A cyst from a follicle that fails to ovulate. It can be dominant (high E2) or non-dominant (low E2).

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What causes the luteal cyst's thickened walls?

Theca and granulosa cells within the cyst undergo luteinization, similar to what happens in the CL.

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How does a luteal cyst differ from a cystic CL?

A luteal cyst secretes varying levels of P4, unlike a normal, healthy CL, which has consistent levels of P4.

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What's the main challenge in diagnosing Ovarian Cysts?

Differentiating a follicular cyst from a luteal cyst can be difficult, even with transrectal exams.

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What's the advantage of ultrasound in diagnosing Ovarian Cysts?

Ultrasound can distinguish between follicular and luteal cysts with better accuracy (around 90%), based on wall thickness.

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What's the main goal of Ovarian Cyst treatment?

To induce increased P4 secretion, decrease LH pulsatility, and sensitize the hypothalamus to E2.

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GnRH and PGF for Ovarian Cysts: How do they work?

GnRH induces luteinization of the dominant cyst. PGF then induces atresia and the development of a new ovulatory follicle.

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Study Notes

Non-infectious Infertility in Cattle

  • This presentation covers non-infectious infertility in cattle, focusing on congenital and acquired conditions.
  • Key learning objectives include understanding differences in sex determination (chromosomal, gonadal, phenotypic), congenital reproductive defects (e.g., freemartinism), neuroendocrine mechanisms of ovarian cyclicity, causes and pathophysiology of anestrus and ovarian cysts, differentiating follicular and luteal cysts, and strategies for prevention and treatment.

Sexual Differentiation

  • Chromosomal Sex: XX (female) and XY (male) determine initial sex.
  • Gonadal Sex: Develops ovaries in females and testes in males.
  • Phenotypic Sex: The physical expression of sex based on the development of internal and external genitalia.

Freemartinism

  • Occurs in 92% of heterosexual twin births.
  • Results from the fusion of chorio-allantoic portions of the twin placentas (occurring 28-30 days post-conception).
  • Common blood supply between the twin fetuses causes the exchange of humoral and cellular elements.
  • Freemartin calves are "chimeras" with 60 chromosomes (58+2).
  • Shows reduced development of Müllerian ducts, resulting in a small genital tract, hypoplastic ovaries, a short vagina, and absent cervix.
  • Increased development of the Wolffian ducts.
  • Development of epididymides, vasa deferentia and vesicular glands.
  • Diagnosis can be made by noting the history of heterosexual twin birth, appearance of external genitalia (small vulva, enlarged clitoris, anestrus), palpation or ultrasound of the internal reproductive tract, and a speculum exam finding a short vagina and absence of external cervical Os. Additionally, a vaginal probe can aid in diagnosis.
  • Karyotyping and PCR are used to determine presence of XY and XX chromosomes in the same animal.

Segmental Aplasia of the Müllerian Ducts

  • An autosomal recessive genetic disorder.
  • Causes a lack of development of a portion of the Müllerian ducts (aplasia).
  • Results in vagina, cervix, uterus and oviduct problems, e.g. hydrosalpinx, hydrometra.
  • Commonly found in certain breeds.
  • Misdiagnosis is possible as this condition may be mistaken for other conditions such as pregnancy, pyometra, mucometra or ovarian cysts.

Incomplete Fusion of the Müllerian Ducts

  • An autosomal dominant condition causing "Uterus Didelphys".
  • Characterized by the failure of complete fusion of the Müllerian ducts, mostly affecting the cervix.
  • Results in double external cervical os.
  • Both external openings are sometimes connected to a normal internal cervical os.
  • In some cases one side ends in a blind diverticulum.
  • May cause dystocia (difficult birth) if fetal parts pass through both external cervical canals, affecting fertility.

Ovarian Hypoplasia

  • A congenital defect characterized by deficient morphologic and functional development of one or both ovaries.
  • Ovaries are small, hard and have no palpable structures.
  • Condition can be inherited.
  • Can be unilateral or bilateral.
  • Unilateral may not affect the entire reproductive tract causing difficulty in detection
  • Bilateral may result in an undeveloped reproductive tract and a smaller pelvis

Anestrus

  • Absence of estrus, ovulation and Corpus Luteum (CL) formation.
  • Inhibition of GnRH and LH secretion.
  • Causes may include high milk yield, undernutrition, negative energy balance, metabolic diseases (e.g., mastitis), pregnancy, presence of calf, heat stress.

Cystic Ovarian Follicles

  • Anovulatory follicular structures that persist for an extended period, often larger than a normal follicle.
  • Prevalence of 10% in dairy cows, compared to lesser prevalence in beef cows.
  • A prolonged interval between calving is often a symptom.
  • Four potential outcomes include luteinization of the follicular cysts (cyst transforms to luteal structure), cyst persistency, cyst regression and cyst turnover

Ovarian Cysts

  • Diagnosis: Characterized by behavioral and physical traits, transrectal examination, and ultrasound.
  • Tx: Treatment focuses on increasing P4 levels after treatment (exogenous or endogenous).
  • Techniques include using GnRH and PGF or progesterone to help decrease LH pulse and induce atresia.

Take-Home Message

  • Congenital and acquired conditions can lead to acyclicity or subfertility.
  • Freemartinism is the most common genetic defect in cattle
  • Prompt identification and treatment can help manage cases and reduce financial loss.

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