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Questions and Answers

What is the most common type of dementia, accounting for approximately 50% of all dementia cases?

  • Wernicke-Korsakoff Syndrome
  • Herpes Simplex Encephalitis
  • Temporal Lobe Epilepsy
  • Alzheimer's Disease (correct)

What type of memory is primarily affected by hippocampal sclerosis?

  • Long-term Memory
  • Storage Memory (correct)
  • Working Memory
  • Sensory Memory

Which of the following statements is true regarding Alzheimer's Disease?

  • It typically presents with language impairment first.
  • Memory impairment is characterized by rapid forgetting. (correct)
  • It is not associated with hippocampal atrophy.
  • Onset is often before age 65.

What is a common result of Wernicke-Korsakoff Syndrome?

<p>Severe anterograde amnesia with confabulation. (A)</p> Signup and view all the answers

Epilepsy that has its onset in the temporal lobe is classified as what type?

<p>Temporal Lobe Epilepsy (D)</p> Signup and view all the answers

Which brain regions are commonly affected in Wernicke-Korsakoff Syndrome due to thiamine deficiency?

<p>Mammillary bodies, thalamus, and hypothalamus (A)</p> Signup and view all the answers

What is a common characteristic of memory impairment in patients after a temporal lobectomy?

<p>Isolation of memory problems related to storage (D)</p> Signup and view all the answers

Which factor is a significant cause of memory impairment in Alzheimer's Disease?

<p>Age-related hippocampal atrophy (C)</p> Signup and view all the answers

Flashcards

Temporal Lobe Epilepsy

A common type of focal onset epilepsy, often caused by scarring (hippocampal sclerosis) in the temporal lobe.

Hippocampal Sclerosis

Scarring of the hippocampus (a part of the brain important for memory), often a result of temporal lobe epilepsy.

Alzheimer's Disease

A common type of dementia, often affecting people over 65, characterized by memory loss as a primary symptom, followed by other cognitive decline.

Wernicke-Korsakoff Syndrome

A brain disorder caused by severe thiamine deficiency, often linked to chronic alcohol use, leading to anterograde amnesia (difficulty forming new memories) and confabulation (making up stories to fill in memory gaps).

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Anterograde Amnesia

Inability to form new memories after a particular point in time.

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Confabulation

Making up stories to fill in gaps in memory, often seen in Wernicke-Korsakoff syndrome.

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Verbal Memory

The ability to remember and recall verbal information, such as stories and word lists.

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Visual Memory

The capacity to remember information based on visual cues, such as images and objects.

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Study Notes

Memory Stores

  • Human memory is comprised of sensory, short-term (working), and long-term memory.
  • Sensory memory lasts less than a second.
  • Short-term memory (working memory) lasts up to a minute, used for immediate tasks.
  • Long-term memory is permanent, long-term storage.
  • Explicit memory is conscious.
    • Declarative memory (facts and events)
      • Episodic memory (personal experiences)
      • Semantic memory (facts and concepts)
  • Implicit memory is unconscious.
    • Procedural memory (skills and tasks).

Memory Processes

  • Memory processes include attention, encoding, storage, and retrieval.
  • Attention is focusing on information to encode it.
  • Encoding is converting information into a format the brain can use.
  • Storage is retaining encoded information.
  • Retrieval is accessing stored information.

Neuropsychological Tests of Memory

  • Verbal memory tests (e.g., short stories, word lists).
  • Visual memory tests (e.g., shapes, objects).
    • Example tests: short stories, word lists (List A, Trial 1-4 responses).

Memory after Temporal Lobectomy

  • Epilepsy is recurrent, unprovoked seizures in the brain, it can be generalised or focal.
  • Temporal lobe epilepsy is a common type of focal onset epilepsy.
  • The most common cause of temporal lobe epilepsy is hippocampal sclerosis (scarring in the temporal lobe).
  • Hippocampal sclerosis leads to isolated memory problems, difficulties with storage.
  • Treatment for intractable temporal lobe epilepsy can involve surgery.

Memory in Alzheimer's Disease

  • Alzheimer's disease is the most common dementia, accounting for about 50% of cases.
  • Onset typically occurs after age 65.
  • The disease often causes hippocampal atrophy.
  • Characterized by primary memory impairment that worsens over time impacting other cognitive functions.
  • Memory problems are characterized by rapid forgetting.

Memory in Wernicke-Korsakoff Syndrome

  • Wernicke-Korsakoff syndrome is caused by thiamine deficiency, often associated with heavy alcohol consumption.
  • Poor diets frequently accompany heavy alcohol use impacting thiamine metabolism.
  • Lesions (damage) to the mammillary bodies, thalamus, hypothalamus, frontal lobes, hippocampus, and cerebellum result, causing issues.
  • Key symptoms include severe anterograde amnesia (inability to form new memories) and confabulation (making up false memories).
  • Recognition memory is usually intact.

Memory in Herpes Simplex Encephalitis

  • Herpes simplex is a virus that can cause encephalitis (brain inflammation).
  • Brain lesions, particularly in the lateral and medial temporal cortex (hippocampus), orbito-frontal cortex, cingulate gyrus, and parietal lobe.
  • Results in an acute confusional state followed by permanent, irreversible memory problems.
  • Symptoms include severe anterograde amnesia and potential semantic memory deficits.
  • Implicit memory and working memory are usually intact.

Recommendations for Patients with Memory Deficits

  • If neuropsychological assessment indicates memory deficits, recommend strategies to manage them.
  • This section asks for specific recommendations.

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