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What is the significance of phagocytosis in the immune response?
What is the significance of phagocytosis in the immune response?
Phagocytosis is crucial as it allows immune cells to engulf and eliminate pathogens, preventing the spread of infection.
Describe the role of the complement system in nonspecific defenses.
Describe the role of the complement system in nonspecific defenses.
The complement system helps to break down pathogen cell walls, attracts phagocytes, and stimulates inflammation.
How does the inflammatory response function to protect the body?
How does the inflammatory response function to protect the body?
The inflammatory response increases blood flow, activates phagocytes, and enhances capillary permeability to limit the spread of infection.
What triggers the body's fever response, and what is its purpose?
What triggers the body's fever response, and what is its purpose?
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What is chemotaxis and its role in the immune response?
What is chemotaxis and its role in the immune response?
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What is the primary function of the lymphatic system in relation to body defenses?
What is the primary function of the lymphatic system in relation to body defenses?
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Describe the difference between nonspecific and specific defenses in immunity.
Describe the difference between nonspecific and specific defenses in immunity.
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Name three components of the first line of defense in innate immunity.
Name three components of the first line of defense in innate immunity.
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What role do phagocytes play in the body's nonspecific defenses?
What role do phagocytes play in the body's nonspecific defenses?
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How do interferons contribute to innate immunity?
How do interferons contribute to innate immunity?
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What is the inflammatory response, and why is it important for body defenses?
What is the inflammatory response, and why is it important for body defenses?
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Explain the significance of fever in the context of nonspecific immunity.
Explain the significance of fever in the context of nonspecific immunity.
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List two examples of secretions that contribute to the body’s physical barrier defenses.
List two examples of secretions that contribute to the body’s physical barrier defenses.
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What role do pyrogens play in the body's defense mechanisms?
What role do pyrogens play in the body's defense mechanisms?
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How does a fever contribute to the body's metabolic processes?
How does a fever contribute to the body's metabolic processes?
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Identify two examples of physical barriers in the body's nonspecific defenses.
Identify two examples of physical barriers in the body's nonspecific defenses.
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What is the role of phagocytes in the immune response?
What is the role of phagocytes in the immune response?
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Explain the process of chemotaxis in relation to immune cells.
Explain the process of chemotaxis in relation to immune cells.
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What function do natural killer (NK) cells serve in the immune system?
What function do natural killer (NK) cells serve in the immune system?
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How do interferons assist in fighting viral infections?
How do interferons assist in fighting viral infections?
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What impact can high body temperatures have on bacterial and viral pathogens?
What impact can high body temperatures have on bacterial and viral pathogens?
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Describe the diapedesis movement relevant to immune cells.
Describe the diapedesis movement relevant to immune cells.
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What are lysozymes, and where can they be found in the body?
What are lysozymes, and where can they be found in the body?
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What is the primary function of phagocytes in the immune response?
What is the primary function of phagocytes in the immune response?
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What are the two main pathways that activate the complement system?
What are the two main pathways that activate the complement system?
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How does the Classical pathway activate the complement system?
How does the Classical pathway activate the complement system?
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Name two types of phagocytic cells and their roles.
Name two types of phagocytic cells and their roles.
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Describe the process of diapedesis in phagocytic cells.
Describe the process of diapedesis in phagocytic cells.
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What is the role of C3b in the complement system?
What is the role of C3b in the complement system?
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What is opsonization and how does it relate to the complement system?
What is opsonization and how does it relate to the complement system?
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What role do interferons play in the immune response?
What role do interferons play in the immune response?
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How do NK cells identify abnormal cells?
How do NK cells identify abnormal cells?
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Describe the role of the membrane attack complex (MAC) in the complement system.
Describe the role of the membrane attack complex (MAC) in the complement system.
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What is the function of perforin released by NK cells?
What is the function of perforin released by NK cells?
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What triggers the activation of the Alternative pathway?
What triggers the activation of the Alternative pathway?
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How does inflammation assist in restoring homeostasis following an injury?
How does inflammation assist in restoring homeostasis following an injury?
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Why are NK cells considered less selective in their targeting of pathogens?
Why are NK cells considered less selective in their targeting of pathogens?
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What aspects of the immune system do interferons stimulate?
What aspects of the immune system do interferons stimulate?
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What outcomes result from the activation of the complement system?
What outcomes result from the activation of the complement system?
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How does chemotaxis assist phagocytic cells in their functions?
How does chemotaxis assist phagocytic cells in their functions?
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What is the primary function of the complement proteins in the blood plasma?
What is the primary function of the complement proteins in the blood plasma?
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What distinguishes microphages from macrophages?
What distinguishes microphages from macrophages?
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Explain how local inflammation manifests in response to injury or infection.
Explain how local inflammation manifests in response to injury or infection.
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Study Notes
Overview of Immunity
- Immunity is the body's ability to resist infections and diseases through specific defense mechanisms.
- Body defenses are categorized into innate (nonspecific) immunity and adaptive (specific) immunity.
- Both mechanisms work together to provide comprehensive protection against pathogens.
Innate Immunity
- Innate immunity is the first line of defense, present at birth, and does not distinguish between threats.
- It includes physical barriers, phagocytic cells, immunological surveillance, interferons, complement system, inflammatory response, and fever.
Physical Barriers
- Form the first line of defense by protecting underlying tissues from microbes.
- Examples include skin, mucous membranes, and secretions (tears, sweat, and stomach acid) containing microbe-killing enzymes (lysozymes).
- Epithelial layers in internal passageways trap and move foreign materials outward.
Phagocytes
- Act as the first line of cellular defense, ingesting and destroying pathogens through phagocytosis.
- Phagocytosis involves the engulfing of microbes via pseudopodia forming phagosome vesicles that are lysed by enzymes.
- Two classes of phagocytic cells:
- Microphages (e.g., neutrophils, eosinophils) enter infected tissues from the bloodstream.
- Macrophages (derived from monocytes) can be either fixed or mobile and can navigate through capillary walls (diapedesis) to respond to infection.
Interferons
- Small proteins released by infected cells, lymphocytes, or macrophages when a virus is detected.
- Interferons stimulate the production of antiviral proteins from uninfected cells, inhibiting viral replication.
- Enhance the activity of macrophages and natural killer (NK) cells.
Immunological Surveillance
- NK cells monitor and destroy abnormal cells (e.g., cancerous or virus-infected cells).
- Comprising 5-10% of circulating lymphocytes, they recognize infected or abnormal cells by their unique antigens.
- NK cells use perforin to create pores in target cell membranes, leading to cell lysis.
Complement System
- Comprises 11 proteins that interact in a cascade to enhance the immune response.
- Activated via two pathways:
- Classical pathway: Initiated by antibody binding to pathogens, leading to quick activation.
- Alternative pathway: Triggered by direct interactions with pathogens, slower activation with no antibodies involved.
- Activation results in increased inflammation, chemotaxis for phagocytes, opsonization for enhanced phagocytosis, and formation of the membrane attack complex (MAC) that lyses pathogens.
Inflammatory Response
- A localized reaction to tissue injury characterized by redness, heat, swelling, and pain.
- Aims to restore homeostasis by removing foreign material, preventing the spread of infection, and facilitating tissue repair.
Fever
- An elevation in body temperature above 37.2°C induced by pyrogens that reset the hypothalamic thermostat.
- Benefits of fever include increased metabolic rate, enhanced immune responses, and inhibition of some pathogens.
Review of Key Concepts
- Immunity: Resistance to infectious agents.
- Innate Immunity: Nonspecific defenses active from birth.
- Adaptive Immunity: Specific responses developed after exposure to pathogens.
- Phagocytosis: Ingestion of pathogens by cells.
- Inflammation: Body's response to injury/infection.
- Chemotaxis: Movement of cells toward damaged/infected tissues guided by chemical signals.
Phagocytic Cells
- Microphages (e.g., neutrophils): Enter tissues to fight infection.
- Macrophages: Derived from monocytes; play critical roles in phagocytosis and immune activation.
NK Cells Function
- Attack infected or abnormal cells by releasing perforin, creating pores that lead to cell death.
Importance of Complement Mechanism
- Enhances immune response through inflammation, attracting phagocytes, and opsonizing pathogens for easier ingestion by immune cells.
Complement Pathways
- Classical Pathway: Rapid activation through antibodies.
- Alternative Pathway: Slower activation through direct pathogen recognition.
Processes Initiated by Complement Activation
- Enhances blood flow and inflammation, attracts phagocytes, stimulates phagocytosis, and lyses target cells.
Inflammatory Responses
- Local tissue responses that prevent infection spread and promote healing.
- Also involved in activating adaptive immune mechanisms.
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