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Questions and Answers

What is the significance of phagocytosis in the immune response?

Phagocytosis is crucial as it allows immune cells to engulf and eliminate pathogens, preventing the spread of infection.

Describe the role of the complement system in nonspecific defenses.

The complement system helps to break down pathogen cell walls, attracts phagocytes, and stimulates inflammation.

How does the inflammatory response function to protect the body?

The inflammatory response increases blood flow, activates phagocytes, and enhances capillary permeability to limit the spread of infection.

What triggers the body's fever response, and what is its purpose?

<p>Fever is triggered by pyrogens and serves to elevate body temperature to accelerate tissue metabolism and inhibit pathogen growth.</p> Signup and view all the answers

What is chemotaxis and its role in the immune response?

<p>Chemotaxis is the movement of phagocytic cells towards infected tissue in response to chemical signals.</p> Signup and view all the answers

What is the primary function of the lymphatic system in relation to body defenses?

<p>The lymphatic system is responsible for defending the body against infections and diseases through immune responses.</p> Signup and view all the answers

Describe the difference between nonspecific and specific defenses in immunity.

<p>Nonspecific defenses are present at birth and do not differentiate between threats, while specific defenses develop after exposure to pathogens and target particular threats.</p> Signup and view all the answers

Name three components of the first line of defense in innate immunity.

<p>Physical barriers, such as skin, mucous membranes, and secretions like tears and sweat.</p> Signup and view all the answers

What role do phagocytes play in the body's nonspecific defenses?

<p>Phagocytes engulf and digest foreign particles and pathogens as part of the immune response.</p> Signup and view all the answers

How do interferons contribute to innate immunity?

<p>Interferons are signaling proteins that inhibit viral replication and activate immune cells in response to infections.</p> Signup and view all the answers

What is the inflammatory response, and why is it important for body defenses?

<p>The inflammatory response is a protective mechanism involving redness, heat, swelling, and pain to isolate and eliminate harmful stimuli.</p> Signup and view all the answers

Explain the significance of fever in the context of nonspecific immunity.

<p>Fever raises body temperature to create an unfavorable environment for pathogens and enhances the efficiency of immune responses.</p> Signup and view all the answers

List two examples of secretions that contribute to the body’s physical barrier defenses.

<p>Tears and stomach acid are two examples of secretions that help flush away and kill microorganisms.</p> Signup and view all the answers

What role do pyrogens play in the body's defense mechanisms?

<p>Pyrogens reset the thermostat in the hypothalamus, leading to increased body temperature which can aid in fighting infections.</p> Signup and view all the answers

How does a fever contribute to the body's metabolic processes?

<p>A fever increases body metabolism and accelerates immune defenses, helping to combat infections more effectively.</p> Signup and view all the answers

Identify two examples of physical barriers in the body's nonspecific defenses.

<p>Skin and mucous membranes are examples of physical barriers that prevent pathogen access.</p> Signup and view all the answers

What is the role of phagocytes in the immune response?

<p>Phagocytes, such as microphages and macrophages, remove debris and pathogens from the body.</p> Signup and view all the answers

Explain the process of chemotaxis in relation to immune cells.

<p>Chemotaxis is the movement of immune cells towards sites of infection, guided by chemical signals.</p> Signup and view all the answers

What function do natural killer (NK) cells serve in the immune system?

<p>NK cells destroy abnormal cells using perforins, which create large pores in the target cell membranes.</p> Signup and view all the answers

How do interferons assist in fighting viral infections?

<p>Interferons are released by activated lymphocytes and help coordinate defenses against viral infections.</p> Signup and view all the answers

What impact can high body temperatures have on bacterial and viral pathogens?

<p>Increased body temperatures can inhibit the growth of some bacteria and viruses.</p> Signup and view all the answers

Describe the diapedesis movement relevant to immune cells.

<p>Diapedesis is the process by which immune cells move out of the bloodstream and into tissues to reach sites of infection.</p> Signup and view all the answers

What are lysozymes, and where can they be found in the body?

<p>Lysozymes are destructive enzymes found in secretions such as sweat and sebaceous glands that help break down pathogens.</p> Signup and view all the answers

What is the primary function of phagocytes in the immune response?

<p>Phagocytes ingest and destroy microbes, cell debris, and other foreign material through phagocytosis.</p> Signup and view all the answers

What are the two main pathways that activate the complement system?

<p>The two main pathways are the Classical pathway and the Alternative pathway.</p> Signup and view all the answers

How does the Classical pathway activate the complement system?

<p>In the Classical pathway, C1 binds to an antibody attached to an antigen, leading to a cascade that activates C proteins and produces C3b.</p> Signup and view all the answers

Name two types of phagocytic cells and their roles.

<p>Microphages (like neutrophils and eosinophils) enter tissues to fight infection, while macrophages are derived from monocytes and are actively phagocytic.</p> Signup and view all the answers

Describe the process of diapedesis in phagocytic cells.

<p>Diapedesis is the movement of phagocytic cells through the capillary wall into tissues, allowing them to reach sites of injury or infection.</p> Signup and view all the answers

What is the role of C3b in the complement system?

<p>C3b is the active form of C3 that promotes opsonization, aiding in the binding of pathogens to phagocytes for destruction.</p> Signup and view all the answers

What is opsonization and how does it relate to the complement system?

<p>Opsonization is the process by which C proteins bind to antibodies on pathogens, making them easier for phagocytes to engulf.</p> Signup and view all the answers

What role do interferons play in the immune response?

<p>Interferons trigger the production of antiviral proteins in normal cells, which inhibit viral replication and stimulate macrophages and NK cells.</p> Signup and view all the answers

How do NK cells identify abnormal cells?

<p>Natural killer (NK) cells recognize abnormal cells by detecting non-normal antigens present on their membranes.</p> Signup and view all the answers

Describe the role of the membrane attack complex (MAC) in the complement system.

<p>The MAC forms pores in the membranes of target cells, leading to cell lysis and destruction of the pathogen.</p> Signup and view all the answers

What is the function of perforin released by NK cells?

<p>Perforin creates pores in the membranes of target cells, leading to their lysis and destruction.</p> Signup and view all the answers

What triggers the activation of the Alternative pathway?

<p>The Alternative pathway is triggered by direct interactions among complement proteins in the presence of bacteria, parasites, or virus-infected cells.</p> Signup and view all the answers

How does inflammation assist in restoring homeostasis following an injury?

<p>Inflammation increases blood flow to the area, disposes of foreign materials, and aids in tissue repair.</p> Signup and view all the answers

Why are NK cells considered less selective in their targeting of pathogens?

<p>NK cells attack any cell that presents foreign antigens, regardless of the identity of the pathogen.</p> Signup and view all the answers

What aspects of the immune system do interferons stimulate?

<p>Interferons stimulate the activities of macrophages and natural killer (NK) cells.</p> Signup and view all the answers

What outcomes result from the activation of the complement system?

<p>Activation of the complement system results in increased inflammation, chemotaxis of phagocytes, stimulation of phagocytosis, and formation of the MAC.</p> Signup and view all the answers

How does chemotaxis assist phagocytic cells in their functions?

<p>Chemotaxis guides phagocytic cells to sites of infection or injury by responding to chemical signals in surrounding fluids.</p> Signup and view all the answers

What is the primary function of the complement proteins in the blood plasma?

<p>The primary function of complement proteins is to enhance the immune response by facilitating the destruction of pathogens.</p> Signup and view all the answers

What distinguishes microphages from macrophages?

<p>Microphages, such as neutrophils, are smaller and enter tissues from the bloodstream, whereas macrophages are larger, derived from monocytes, and can be fixed or free-moving.</p> Signup and view all the answers

Explain how local inflammation manifests in response to injury or infection.

<p>Local inflammation results in redness, swelling, heat, and pain at the site of injury or infection.</p> Signup and view all the answers

Study Notes

Overview of Immunity

  • Immunity is the body's ability to resist infections and diseases through specific defense mechanisms.
  • Body defenses are categorized into innate (nonspecific) immunity and adaptive (specific) immunity.
  • Both mechanisms work together to provide comprehensive protection against pathogens.

Innate Immunity

  • Innate immunity is the first line of defense, present at birth, and does not distinguish between threats.
  • It includes physical barriers, phagocytic cells, immunological surveillance, interferons, complement system, inflammatory response, and fever.

Physical Barriers

  • Form the first line of defense by protecting underlying tissues from microbes.
  • Examples include skin, mucous membranes, and secretions (tears, sweat, and stomach acid) containing microbe-killing enzymes (lysozymes).
  • Epithelial layers in internal passageways trap and move foreign materials outward.

Phagocytes

  • Act as the first line of cellular defense, ingesting and destroying pathogens through phagocytosis.
  • Phagocytosis involves the engulfing of microbes via pseudopodia forming phagosome vesicles that are lysed by enzymes.
  • Two classes of phagocytic cells:
    • Microphages (e.g., neutrophils, eosinophils) enter infected tissues from the bloodstream.
    • Macrophages (derived from monocytes) can be either fixed or mobile and can navigate through capillary walls (diapedesis) to respond to infection.

Interferons

  • Small proteins released by infected cells, lymphocytes, or macrophages when a virus is detected.
  • Interferons stimulate the production of antiviral proteins from uninfected cells, inhibiting viral replication.
  • Enhance the activity of macrophages and natural killer (NK) cells.

Immunological Surveillance

  • NK cells monitor and destroy abnormal cells (e.g., cancerous or virus-infected cells).
  • Comprising 5-10% of circulating lymphocytes, they recognize infected or abnormal cells by their unique antigens.
  • NK cells use perforin to create pores in target cell membranes, leading to cell lysis.

Complement System

  • Comprises 11 proteins that interact in a cascade to enhance the immune response.
  • Activated via two pathways:
    • Classical pathway: Initiated by antibody binding to pathogens, leading to quick activation.
    • Alternative pathway: Triggered by direct interactions with pathogens, slower activation with no antibodies involved.
  • Activation results in increased inflammation, chemotaxis for phagocytes, opsonization for enhanced phagocytosis, and formation of the membrane attack complex (MAC) that lyses pathogens.

Inflammatory Response

  • A localized reaction to tissue injury characterized by redness, heat, swelling, and pain.
  • Aims to restore homeostasis by removing foreign material, preventing the spread of infection, and facilitating tissue repair.

Fever

  • An elevation in body temperature above 37.2°C induced by pyrogens that reset the hypothalamic thermostat.
  • Benefits of fever include increased metabolic rate, enhanced immune responses, and inhibition of some pathogens.

Review of Key Concepts

  • Immunity: Resistance to infectious agents.
  • Innate Immunity: Nonspecific defenses active from birth.
  • Adaptive Immunity: Specific responses developed after exposure to pathogens.
  • Phagocytosis: Ingestion of pathogens by cells.
  • Inflammation: Body's response to injury/infection.
  • Chemotaxis: Movement of cells toward damaged/infected tissues guided by chemical signals.

Phagocytic Cells

  • Microphages (e.g., neutrophils): Enter tissues to fight infection.
  • Macrophages: Derived from monocytes; play critical roles in phagocytosis and immune activation.

NK Cells Function

  • Attack infected or abnormal cells by releasing perforin, creating pores that lead to cell death.

Importance of Complement Mechanism

  • Enhances immune response through inflammation, attracting phagocytes, and opsonizing pathogens for easier ingestion by immune cells.

Complement Pathways

  • Classical Pathway: Rapid activation through antibodies.
  • Alternative Pathway: Slower activation through direct pathogen recognition.

Processes Initiated by Complement Activation

  • Enhances blood flow and inflammation, attracts phagocytes, stimulates phagocytosis, and lyses target cells.

Inflammatory Responses

  • Local tissue responses that prevent infection spread and promote healing.
  • Also involved in activating adaptive immune mechanisms.

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2023 HUB105 Lec 12 Innate.pdf

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