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Intergrated aging disorders

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Questions and Answers

Which one of the following statements concerning progeria is incorrect?

Cultured fibroblasts from children with progeria often have a shorter lifespan compared to fibroblasts from normal children of similar age
There are approximately 30 cases worldwide
Progeria is also known as the Hutchinson- Gilford syndrome
Progeria patients always have a low secretion of hyaluronic acid in their urine (correct)

Which one of the following statements is incorrect?

Telomeres are protective caps at end of chromosomes
The error catastrophe theory is concerned with glycation of proteins (correct)
Antioxidants protect against free radicals
Liver cells from older mice have greater number of mutations compared to similar cells from younger mice

A free radical can be defined as:

An atom or molecule with no charge
An atom or molecule that is reactive
An atom or molecule with one or more unpaired electrons (correct)
An atom or molecule with no unpaired electrons

Alzheimer's disease

is characterised by deposition of B-amyloid in the brain (A) Signup and view all the answers

Which one of the following statements in incorrect?

Transplanting the nucleus of a young cell into an old cytoplasm will give a new cell with the same lifespan of the cytoplasm (C) Signup and view all the answers

Which ONE of the following statement is INCORRECT?

lipofuscin accumulation decreases with cellular ageing (C) Signup and view all the answers

Which ONE of the following disorders is NOT related to ageing?

Asperger's syndrome (A) Signup and view all the answers

Which ONE of the following diseases is NOT associated with ageing?

Phenylketonuria (D) Signup and view all the answers

Which ONE of the following statements is TRUE?

calorie restriction in rodents is known to extend their lifespan (D) Signup and view all the answers

Which ONE of the following statements is INCORRECT

Cancer is a major cause of death in progeria (C) Signup and view all the answers

A major waste product in ageing is?

Lipofuscin (B) Signup and view all the answers

Ageing is defined as:

A decreasing ability to survive (A) Signup and view all the answers

Which one of the following statements most accurately describes the primary role of micro RNAs within the cell;

Post-transcriptional regulation of gene expression through inhibition of translation (D) Signup and view all the answers

Which ONE of the following statements is true?

Calorie restriction increases lifespan in rodents (D) Signup and view all the answers

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