Intergrated aging disorders

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Questions and Answers

Which one of the following statements concerning progeria is incorrect?

  • Cultured fibroblasts from children with progeria often have a shorter lifespan compared to fibroblasts from normal children of similar age
  • There are approximately 30 cases worldwide
  • Progeria is also known as the Hutchinson- Gilford syndrome
  • Progeria patients always have a low secretion of hyaluronic acid in their urine (correct)

Which one of the following statements is incorrect?

  • Telomeres are protective caps at end of chromosomes
  • The error catastrophe theory is concerned with glycation of proteins (correct)
  • Antioxidants protect against free radicals
  • Liver cells from older mice have greater number of mutations compared to similar cells from younger mice

A free radical can be defined as:

  • An atom or molecule with no charge
  • An atom or molecule that is reactive
  • An atom or molecule with one or more unpaired electrons (correct)
  • An atom or molecule with no unpaired electrons

Alzheimer's disease

<p>is characterised by deposition of B-amyloid in the brain (A)</p> Signup and view all the answers

Which one of the following statements in incorrect?

<p>Transplanting the nucleus of a young cell into an old cytoplasm will give a new cell with the same lifespan of the cytoplasm (C)</p> Signup and view all the answers

Which ONE of the following statement is INCORRECT?

<p>lipofuscin accumulation decreases with cellular ageing (C)</p> Signup and view all the answers

Which ONE of the following disorders is NOT related to ageing?

<p>Asperger's syndrome (A)</p> Signup and view all the answers

Which ONE of the following diseases is NOT associated with ageing?

<p>Phenylketonuria (D)</p> Signup and view all the answers

Which ONE of the following statements is TRUE?

<p>calorie restriction in rodents is known to extend their lifespan (D)</p> Signup and view all the answers

Which ONE of the following statements is INCORRECT

<p>Cancer is a major cause of death in progeria (C)</p> Signup and view all the answers

A major waste product in ageing is?

<p>Lipofuscin (B)</p> Signup and view all the answers

Ageing is defined as:

<p>A decreasing ability to survive (A)</p> Signup and view all the answers

Which one of the following statements most accurately describes the primary role of micro RNAs within the cell;

<p>Post-transcriptional regulation of gene expression through inhibition of translation (D)</p> Signup and view all the answers

Which ONE of the following statements is true?

<p>Calorie restriction increases lifespan in rodents (D)</p> Signup and view all the answers

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