Chapter 11 The Endocrine System

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Questions and Answers

Which of the following statements is NOT true of the endocrine system?

  • It is one of two major regulatory systems of the body.
  • It is composed of glands that secrete chemical messengers into the blood.
  • It is an important regulator of homeostatic mechanisms.
  • It influences and is influenced by the nervous system.
  • Most of its components are anatomically connected, like most other systems of the body. (correct)

Which of the following statements does NOT apply to hormones?

  • They are chemical regulators that are conveyed from one organ to another via the bloodstream.
  • In some cases, the same chemical substances can also function as local regulators and/or neurotransmitters.
  • All hormones are derived from cholesterol. (correct)
  • They are secreted into the blood by ductless glands.
  • They are sometimes secreted by neural tissue.

When examining an endocrine cell from a new species of mammal under the microscope, you find that it contains an abundance of rough endoplasmic reticulum, a large Golgi apparatus, and secretory granules. Which of the following is most likely to be true about these cells?

  • It secretes a peptide/protein hormone. (correct)
  • It secretes its product by diffusion through the lipid bilayer of the plasma membrane.
  • It secretes by endocytosis.
  • Its hormone product is synthesized from cholesterol.
  • It secretes a hormone with a hydrophobic structure.

Which is most likely a characteristic of cells that secrete steroid hormones?

<p>They are characterized by abundant smooth endoplasmic reticulum and few secretory granules. (B)</p> Signup and view all the answers

Which is TRUE regarding the structure and synthesis of hormones?

<p>Steroid hormones are synthesized from cholesterol. (A)</p> Signup and view all the answers

What is the definition of a prohormone?

<p>A longer protein or peptide that is cleaved into shorter ones, at least one of which is a peptide or protein hormone (C)</p> Signup and view all the answers

Which of the following statements about hormone synthesis is NOT correct?

<p>Tryptophan is a precursor for thyroid hormones. (D)</p> Signup and view all the answers

Which of the following options would most directly decrease the production of aldosterone?

<p>Injecting a drug that blocks the production of angiotensin II (@)</p> Signup and view all the answers

In a hypothetical rare genetic disease in which the ribosomes in some cells of the anterior pituitary are malformed, which hormone, if any, would you expect to be missing from a patient with this disease?

<p>Growth hormone (A)</p> Signup and view all the answers

A hormone may be which of the following?

<p>All of the choices could be correct. (@)</p> Signup and view all the answers

What does a hormone's concentration in the plasma depend upon?

<p>Both &quot;Its rate of secretion&quot; and &quot;Its rate of clearance&quot; (D)</p> Signup and view all the answers

Your patient has advanced stage cancer and her liver is starting to fail. One consequence is markedly reduced plasma proteins. In what way might this affect her endocrine system?

<p>A reduction in the rate of hydrophobic hormones like steroid and thyroid hormones reaching their target tissues (D)</p> Signup and view all the answers

Which is NOT an endocrine function performed by the liver?

<p>Secreting insulin (@)</p> Signup and view all the answers

What is a main difference between the modes of action of peptide hormones and steroid hormones?

<p>Peptide hormones bind to receptors on the cell surface, whereas steroid hormones bind to intracellular receptors. (D)</p> Signup and view all the answers

You have discovered a novel steroid hormone. You'd like to isolate its receptor as part of your next project. Where should you look first?

<p>In the cytoplasm (C)</p> Signup and view all the answers

Which is NOT true about receptors for steroid hormones?

<p>They are highly soluble in blood plasma. (D)</p> Signup and view all the answers

You have discovered a novel hormone. Early experiments have shown that it is quite hydrophobic. Which of the following is likely to also be TRUE of these hormones?

<p>Their mechanism of action generally involves altering protein synthesis. (D)</p> Signup and view all the answers

Acting alone, epinephrine and thyroid hormone each stimulate the release of only a small amount of fatty acids from adipose cells. In the presence of thyroid hormone, epinephrine causes a much more substantial release of fatty acids from the cells. What is the term describing the effect of thyroid hormone on epinephrine's actions?

<p>Permissive (C)</p> Signup and view all the answers

What term describes hormones that influence the secretion of other hormones?

<p>Tropic (C)</p> Signup and view all the answers

Which of the following statements about oxytocin is TRUE?

<p>Oxytocin is synthesized in the hypothalamus. (B)</p> Signup and view all the answers

Which accurately describes the median eminence of the hypothalamus?

<p>It is a site where neurohormones are released into blood vessels that pass directly to the anterior pituitary. (B)</p> Signup and view all the answers

Sally is a 10-year-old girl going through a growth spurt. Her blood levels of growth hormone are two-fold higher than at the same time last week. Which other hormones are likely to also be elevated?

<p>Insulin-like growth factor 1 (A)</p> Signup and view all the answers

Which of these describes secondary hypersecretion of hormone X?

<p>A growing tumor secretes hormone Y, which stimulates the gland that secretes hormone X. (A)</p> Signup and view all the answers

Which of the following hormones is NOT secreted by the anterior pituitary gland?

<p>Erythropoietin (D)</p> Signup and view all the answers

What term describes hormones secreted by the hypothalamus that regulate the secretion of hormones from the anterior pituitary gland?

<p>Hypophysiotropic hormones (C)</p> Signup and view all the answers

Which is an example of long-loop negative feedback?

<p>Inhibition of growth hormone-releasing hormone (GHRH) release by insulin-like growth factor-1 (C)</p> Signup and view all the answers

Which of the following statements about hormones is correct?

<p>All hormones secreted by the anterior and posterior pituitary glands are peptides. (B)</p> Signup and view all the answers

A chemical precursor for cortisol is _________, which is made from _________. Cortisol is secreted by the _________ when stimulated by _________ from the anterior pituitary.

<p>progesterone; cholesterol; adrenal cortex; adrenocorticotropic hormone (ACTH) (D)</p> Signup and view all the answers

Which is an accurate description of the posterior pituitary and its functions?

<p>It is neural tissue, and vesicles containing oxytocin and vasopressin are transported to axon terminals there. (C)</p> Signup and view all the answers

Which is a function of the gonadotropic hormones?

<p>Inducing the secretion of steroid hormones by the gonads in both males and females (D)</p> Signup and view all the answers

If the adrenal glands were removed from a patient, his plasma cortisol levels would_________, secretion of CRH by the_________ would_________, and secretion of ACTH by the_________ would_________.

<p>decrease; hypothalamus; increase; adenohypophysis; increase (B)</p> Signup and view all the answers

Which of these could be a cause of hypertrophy of the adrenal cortex?

<p>Low levels of cortisol in the circulation (@)</p> Signup and view all the answers

You have a patient complaining of fatigue and lethargy. She mentions that she recently went on a low-salt, all carbohydrate diet and consumes mostly rice. You notice a swelling in her neck. You order some blood work. Which of the following do you expect?

<p>Low plasma concentration of thyroid hormones (B)</p> Signup and view all the answers

Which would be the effect of a blood clot that blocked the vessels of the hypothalamo-pituitary portal system in the infundibulum between the hypothalamus and the anterior pituitary gland?

<p>Secretion of adrenocorticotropic hormone (ACTH) would decrease and the adrenal cortex would atrophy (A)</p> Signup and view all the answers

It’s final exam time and you’re finding yourself extremely stressed out. If we examined your blood, which of the following would we be likely to find?

<p>Increased secretion of corticotropin from the anterior pituitary (A)</p> Signup and view all the answers

Short-loop negative feedback occurs when hormones from the_________ inhibit hormone secretion by the_________.

<p>anterior pituitary; hypothalamus (C)</p> Signup and view all the answers

If the pituitary gland is removed from a human subject, which of the following is likely to occur?

<p>The adrenal gland will atrophy and plasma cortisol levels will be reduced. (B)</p> Signup and view all the answers

Which are hormones secreted by the posterior pituitary?

<p>Antidiuretic hormone (ADH) and oxytocin (@)</p> Signup and view all the answers

Which stimulates the secretion of growth hormone?

<p>Exercise (B)</p> Signup and view all the answers

Deficiency of iodine in the diet results in_________ caused by_________.

<p>a goiter; loss of negative feedback by thyroid hormones and increased thyroid-stimulating hormone (TSH) levels (C)</p> Signup and view all the answers

A patient goes to her doctor, complaining of fatigue, weight gain, and intolerance to cold. She also has a noticeable goiter in her neck. Which of the following is the most likely diagnosis and cause?

<p>She has hypothyroidism, possibly due to low iodine in her diet. (C)</p> Signup and view all the answers

Which is most likely a result of hypersecretion of growth hormone?

<p>Acromegaly (A)</p> Signup and view all the answers

A patient appears in a clinic complaining of irritability and chronic sweatiness. He also has a lump in his neck near his larynx. Blood tests show he has low levels of thyroid-stimulating hormone (TSH) in his plasma. Which of the following is the most likely diagnosis?

<p>Graves' disease (@)</p> Signup and view all the answers

To synthesize thyroid hormones, iodine is attached to which of the following?

<p>the amino acid tyrosine (B)</p> Signup and view all the answers

Which is a result of elevated thyroid hormone levels?

<p>Increased Na+/K+ ATPase activity (B)</p> Signup and view all the answers

Which is a result of an absence of thyroid hormones during fetal development?

<p>Congenital hypothyroidism (C)</p> Signup and view all the answers

You are designing an experiment to quantify the levels of stress experienced by different individuals. Which of the following tests would reveal insight into a patient's chronic stress?

<p>Testing plasma levels of cortisol (@)</p> Signup and view all the answers

What is the major hormone responsible for mediating the body's general response to stress?

<p>Cortisol (@)</p> Signup and view all the answers

Which of the following is NOT stimulated by cortisol during stress?

<p>Glucose uptake into muscle cells (C)</p> Signup and view all the answers

You’re studying long-term stress in foster children. You expect to find_________ among the children experiencing the most significant stress for the longest period of time.

<p>bone and muscle density (B)</p> Signup and view all the answers

Which of the following is an action of the sympathetic nervous system during stress?

<p>It increases the ability to respond to situations where physical activity is required. (B)</p> Signup and view all the answers

Which of the following hormones is NOT usually secreted at higher levels in response to stress?

<p>Gonadotropins (B)</p> Signup and view all the answers

Which statement best describes the manner in which growth hormone stimulates cell proliferation?

<p>It stimulates the release of insulin-like growth factor I (IGF-1) from the liver and other target tissues of growth hormone. (B)</p> Signup and view all the answers

At what time in the lifespan is the growth hormone secretion rate highest?

<p>During adolescence (C)</p> Signup and view all the answers

Which is true about the growth of long bones?

<p>Growth in length occurs at two epiphyseal growth plates near the ends of long bones. (@)</p> Signup and view all the answers

In what form is the body's largest pool of calcium?

<p>Bones, in the form of hydroxyapatites (D)</p> Signup and view all the answers

During a long illness, Terrell has not been eating much. As a result, his plasma Ca2+ levels decrease. Which hormone would we expect to see in higher levels than usual in his blood?

<p>Parathyroid hormone (A)</p> Signup and view all the answers

Which is NOT an effect of parathyroid hormone?

<p>Decreases reabsorption of calcium by the kidneys (B)</p> Signup and view all the answers

Which would result from a vitamin D deficiency?

<p>An increase in parathyroid hormone levels (C)</p> Signup and view all the answers

Which of the following is TRUE regarding pituitary growth hormone (GH)?

<p>GH stimulates insulin-like growth factor-1 (IGF-1) production by the liver and by many other cells. (B)</p> Signup and view all the answers

Which of the following is NOT true of pituitary growth hormone?

<p>It is necessary for fetal growth. (@)</p> Signup and view all the answers

Baby Sylvia is born with a thyroid deficiency. Which of the following can we expect for Sylvia if it goes untreated?

<p>Growth rate will be slower than normal. (D)</p> Signup and view all the answers

A deficiency in dietary iodine can cause which of the following?

<p>All of the choices are correct. (@)</p> Signup and view all the answers

Which correctly lists a function of estrogens in females and testosterone in males?

<p>They stimulate the reabsorption of bone. (@)</p> Signup and view all the answers

Flashcards

Endocrine System Anatomy

Unlike most body systems, the endocrine system's components are not anatomically connected.

Hormone Composition

Not all hormones are derived from cholesterol; some are proteins or peptides.

Peptide/Protein Hormone Secretion

Cells secreting peptide/protein hormones have abundant rough ER, Golgi apparatus, and secretory granules due to the protein synthesis and packaging process.

Steroid Hormone Secretion

Steroid hormone secreting cells have abundant smooth endoplasmic reticulum for cholesterol synthesis and fewer secretory granules.

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Steroid Hormone Synthesis

Steroid hormones are synthesized from cholesterol.

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Prohormone

An inactive precursor protein or peptide that is cleaved to produce one or more active hormones.

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Tryptophan's Role

Tryptophan is a precursor for melatonin and serotonin, not thyroid hormones.

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Aldosterone Production

Blocking angiotensin II production directly reduces aldosterone production, because angiotensin II stimulates aldosterone synthesis.

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Growth Hormone Production

Growth hormone would likely be missing due to the malformed ribosomes' inability to synthesize the protein hormone.

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Hormone Types

Hormones can be peptides, proteins, steroids, or amines.

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