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5-HT Receptors and Antagonists

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Questions and Answers

What type of receptor antagonist is used to treat chemotherapy-induced nausea and vomiting?

5-HT1A antagonist

5-HT4 antagonist

5-HT3 antagonist (correct)

5-HT2A/2C antagonist

Which medication is an example of a 5-HT2A/2C antagonist used to treat schizophrenia?

Buspirone

Risperidone (correct)

Clozapine

Sumatriptan

What is the clinical indication for the 5-HT1D receptor agonist Sumatriptan?

Obesity

Anxiety

Migraine and cluster headache attacks (correct)

Depression

Which antihistamine medication is recommended to counteract the effects of histamine release with the least impact on mental status?

Loratadine Signup and view all the answers

Which medication is an example of a drug that can produce histamine release?

Morphine Signup and view all the answers

What is the clinical indication for the 5-HT4 receptor agonist Prucalopride?

IBS with diarrhea Signup and view all the answers

What is the mechanism of action of H2 receptor blockers?

They competitively and reversibly block H2 receptors on the parietal cells to reduce basal acid secretion. Signup and view all the answers

What is the effect of 5-HT on blood vessels?

Contraction Signup and view all the answers

Which of the following is a 5-HT receptor agonist?

Lorcaserin Signup and view all the answers

What is the therapeutic use of antihistamine medications such as dimenhydrinate and meclizine?

Treatment of motion sickness Signup and view all the answers

What is the mechanism of action of 5-HT3 receptors?

Ligand-gated Na+ and K+ channels Signup and view all the answers

Which of the following is a 5-HT receptor antagonist?

Methysergide Signup and view all the answers

What is the primary site of histamine biosynthesis?

Site of action Signup and view all the answers

What is the primary reason for histamine release in allergic conditions?

To respond to the presence of allergens Signup and view all the answers

What is the effect of histamine on cardiac contractility and heart rate?

It increases cardiac contractility and heart rate Signup and view all the answers

What is the mechanism of action of glucocorticoids in relation to histamine?

They stabilize mast cells and inhibit histamine release Signup and view all the answers

What is the primary effect of H1 antagonists?

They inhibit histamine-induced contraction of bronchial smooth muscle Signup and view all the answers

What is the primary route of excretion for histamine?

Urine Signup and view all the answers