18 Questions
What type of receptor antagonist is used to treat chemotherapy-induced nausea and vomiting?
5-HT3 antagonist
Which medication is an example of a 5-HT2A/2C antagonist used to treat schizophrenia?
Risperidone
What is the clinical indication for the 5-HT1D receptor agonist Sumatriptan?
Migraine and cluster headache attacks
Which antihistamine medication is recommended to counteract the effects of histamine release with the least impact on mental status?
Loratadine
Which medication is an example of a drug that can produce histamine release?
Morphine
What is the clinical indication for the 5-HT4 receptor agonist Prucalopride?
IBS with diarrhea
What is the mechanism of action of H2 receptor blockers?
They competitively and reversibly block H2 receptors on the parietal cells to reduce basal acid secretion.
What is the effect of 5-HT on blood vessels?
Contraction
Which of the following is a 5-HT receptor agonist?
Lorcaserin
What is the therapeutic use of antihistamine medications such as dimenhydrinate and meclizine?
Treatment of motion sickness
What is the mechanism of action of 5-HT3 receptors?
Ligand-gated Na+ and K+ channels
Which of the following is a 5-HT receptor antagonist?
Methysergide
What is the primary site of histamine biosynthesis?
Site of action
What is the primary reason for histamine release in allergic conditions?
To respond to the presence of allergens
What is the effect of histamine on cardiac contractility and heart rate?
It increases cardiac contractility and heart rate
What is the mechanism of action of glucocorticoids in relation to histamine?
They stabilize mast cells and inhibit histamine release
What is the primary effect of H1 antagonists?
They inhibit histamine-induced contraction of bronchial smooth muscle
What is the primary route of excretion for histamine?
Urine
This quiz covers the different types of 5-HT receptors, their actions, and clinical indications, including agonists and antagonists used to treat various disorders such as anxiety, migraine, and schizophrenia.
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