Lecture 20:Action Potentials

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Questions and Answers

An action potential is a trnasient, regenerative electrical impulse in which the membrane potential(Vm) rapidly rises to a peak about 100 mV more positive than the normal, negative resting voltage.

True (A)

What cells does an action potential occur in?

  • electrically excitable; communicates action (correct)
  • electrically exhausted; communicates loss of energy
  • physically active
  • physically exhausted

The key to action potentials is voltage-gated channels that open and close based on changes in Vm.

True (A)

What kind of action potential do nerve and skeletal muscle have?

<p>rapid transmission (A)</p> Signup and view all the answers

What kind of action potential does the heart have?

<p>prolonged repolarization phase to give heart muscle extra time to contract and push blood (D)</p> Signup and view all the answers

A stimulus is small ion movements across the membrane that depolarize Vm.

<p>True (A)</p> Signup and view all the answers

What causes an AP to be triggered?

<p>if Vm reaches threshold level-threshold voltage causes voltage gated channels to open (B)</p> Signup and view all the answers

What phase is Vm decaying back to resting potential?

<p>repolarizing (B)</p> Signup and view all the answers

Threshold triggers action potential!!!!!!!

<p>True (A)</p> Signup and view all the answers

What are the action potential phases controlled by?

<p>voltage gated ion channels (C)</p> Signup and view all the answers

Changes in what opens and closes specific channels?

<p>Vm (D)</p> Signup and view all the answers

What is an absolute refractory period?

<p>A second response is not possible regardless of strength or duration of the stimulus. (C)</p> Signup and view all the answers

Relative Refractory Period

<p>a second response can be elicited, but at a greater &quot;cost&quot;(strength and/ or duration) (A)</p> Signup and view all the answers

What is the voltage gated structure like?

<p>6 TM helices, voltage pore, voltage sensor, 4 units form 1 channel (A)</p> Signup and view all the answers

What is special about the voltage-sensor?

<p>-S4(helix 4) has multiple charged residues(+, lys, or arg) -S4 helix changes position as Vm changes: voltage sensor -induces conformational change in channel -affects open probability -highly conserved feature of voltage-gated channels</p> Signup and view all the answers

What "S" helix makes up part of the P-region(pore)?

<p>S6 (C)</p> Signup and view all the answers

The pore region is where inhibitors block and bind. They provide selectivity for ion type.

<p>True (A)</p> Signup and view all the answers

How many units come together to form a channel?

<p>4 (D)</p> Signup and view all the answers

What is electrotonic conduction?

<p>sub-threshold changes in Vm weaken with distance due to loss of energy to the medium (B)</p> Signup and view all the answers

Active Zone

<p>position of AP initiation (C)</p> Signup and view all the answers

What could cause a decrease in the probability of firing an AP?

<p>increase in distance from the active zone (A)</p> Signup and view all the answers

What are the two strategies to fix resistance and leaks in membrane ion channels?

<ol> <li>increase the diameter of the axon to decrease resistance of axon 2)add insulation on the membrane to stop ion leaks(prevents passive current flow across membranes)</li> </ol> Signup and view all the answers

The membrane and distance are resistors.

<p>True (A)</p> Signup and view all the answers

Myelination

<p>-myelin acts as an insulator -current only flows at nodes of Ranvier -density of channels very high at nodes -nodes become active zone for AP propagation -AP goes node to node called saltatory conduction -very rapid propagation</p> Signup and view all the answers

MS

<p>-membranes of nerve cells lose resistance -membrane capacitance increases -changes in Vm cannot be effectively transmitted -action potentials fail to propagate -loss of nerve function:paralysis, lost sensation</p> Signup and view all the answers

A patient has a defect in the number of voltage gated Na+ channels in his nerve cells. The channels are normal in every way, but there are roughly 1/2 the channels in this patients nerve cells relative to a normal patient. Compared to a patient with the normal number of Na+ channels in the nerve cells, how will the defect affect the patient's action potentials?

<p>His action potentials will have a slower depolarizing phase compared to a normal patient. (B)</p> Signup and view all the answers

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