Untitled Quiz

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the primary hormone released by the adrenal cortex during the stress response?

  • Cortisol (correct)
  • Adrenaline
  • Epinephrine
  • Norepinephrine

Which of the following effects is NOT associated with the sympathetic nervous system's response?

  • Increased heart rate
  • Bronchodilation
  • Vasodilation of skeletal muscles
  • Induced osteogenesis (correct)

During the alarm stage of the general adaptation syndrome, what happens to cortisol levels?

  • They decrease significantly
  • They remain constant
  • They peak and quickly drop
  • They increase (correct)

What physiological change occurs in the liver during the sympathetic nervous system's response?

<p>Increased gluconeogenesis (C)</p> Signup and view all the answers

In terms of blood vessels, which response is associated with the sympathetic nervous system during stress?

<p>Vasoconstriction of the liver and vasodilation of the heart (D)</p> Signup and view all the answers

Which physiological effect is a result of increased mental agility during the sympathetic nervous system response?

<p>Enhanced cognitive functions (A)</p> Signup and view all the answers

What happens to urination levels during the sympathetic nervous system's activation?

<p>Decreased urination due to sphincter contraction (C)</p> Signup and view all the answers

Which of the following is a component of the endocrine system's stress response?

<p>Direct release of epinephrine from adrenal medulla (D)</p> Signup and view all the answers

What factor appeared to not influence allostatic load scores among different demographic groups?

<p>Education level (A), Financial status (B)</p> Signup and view all the answers

At what age did the gap in allostatic load scores between African American women and White individuals become notably pronounced?

<p>30 years (A)</p> Signup and view all the answers

What is the relationship suggested between adversity/stress and allostatic load?

<p>Higher levels of stress lead to higher allostatic load. (D)</p> Signup and view all the answers

What significant factor affected African American women's allostatic load scores compared to White women?

<p>Racism and sexism (D)</p> Signup and view all the answers

What percentage of Black women had a high allostatic load score by age 64 according to the findings?

<blockquote> <p>80% (A)</p> </blockquote> Signup and view all the answers

What does the term 'weathering' refer to in this context?

<p>The accumulation of stressors over time leading to poor health. (A)</p> Signup and view all the answers

In terms of allostatic load, how do White individuals' scores compare to those of African Americans as they age?

<p>African Americans maintain higher scores across all ages. (B)</p> Signup and view all the answers

What is the definition of trauma as provided in the findings?

<p>An overwhelming event that one's coping ability cannot manage. (C)</p> Signup and view all the answers

Which statement best reflects the findings regarding allostatic load and financial status?

<p>Income level does not determine allostatic load outcomes. (A)</p> Signup and view all the answers

What role does Major Histocompatibility Complex (MHC) play in the immune system?

<p>It differentiates self from non-self proteins. (B)</p> Signup and view all the answers

Which cells primarily recognize MHC1 complexes?

<p>Cytotoxic T cells and NK cells (D)</p> Signup and view all the answers

Which of the following statements about MHC2 is true?

<p>MHC2 is involved in the adaptive immune response. (A)</p> Signup and view all the answers

What happens once a Helper T-cell is activated?

<p>It activates B cells and T cells, leading to proliferation. (C)</p> Signup and view all the answers

Which type of cell carries MHC2 complexes?

<p>Antigen-presenting cells (C)</p> Signup and view all the answers

Which of the following is NOT a function of Cytotoxic T cells in relation to MHC?

<p>They present antigens to Helper T cells. (B)</p> Signup and view all the answers

How does the MHC complex influence the type of immune response generated?

<p>By activating specific T cells and B cells in response to pathogens. (C)</p> Signup and view all the answers

Which cytokines are responsible for triggering fever and sickness behavior?

<p>IL-1, IL-6, and TNF-alpha (C)</p> Signup and view all the answers

What is the primary function of cytokines IL-1, IL-6, and TNF-alpha on the hypothalamus?

<p>To trigger fever (B)</p> Signup and view all the answers

What effect do IL-1, IL-6, and TNF-alpha have on bone marrow?

<p>They stimulate the production of leukocytes. (C)</p> Signup and view all the answers

Which process is described by the term leukocytosis?

<p>Increase in white blood cell production (A)</p> Signup and view all the answers

How do IL-1, IL-6, and TNF-alpha influence fat and muscle tissue?

<p>They induce protein and fat mobilization. (D)</p> Signup and view all the answers

What is the role of dendritic cells in response to IL-1, IL-6, and TNF-alpha?

<p>They migrate to local lymph nodes to present antigens. (A)</p> Signup and view all the answers

Which acute phase response proteins are increased by the action of these cytokines on the liver?

<p>CRP and MBL (C)</p> Signup and view all the answers

What is the primary purpose of the sickness behavior induced by these cytokines?

<p>To conserve energy for fighting infection (A)</p> Signup and view all the answers

What common effect do IL-1, IL-6, and TNF-alpha have on metabolism?

<p>They promote the breakdown of muscles. (D)</p> Signup and view all the answers

Which receptor type do cytokines like IL-1, IL-6, and TNF-alpha bind to after reaching critical bloodstream concentrations?

<p>Distant receptors throughout the body (B)</p> Signup and view all the answers

What is the primary role of adrenaline, cortisol, and NE in response to stress or trauma?

<p>To aid in fleeing from danger temporarily (C)</p> Signup and view all the answers

How does prolonged exposure to stress and trauma affect DNA expression over generations?

<p>It can lead to changes that accumulate as allostatic load (D)</p> Signup and view all the answers

What misconception is primarily associated with the perceptions of black bodies in dangerous situations?

<p>They are thought to be impervious to pain (C)</p> Signup and view all the answers

What is the implied consequence for white individuals who oppose established social structures?

<p>Loss of privilege and relationships (C)</p> Signup and view all the answers

Which aspect of the vagus nerve is crucial for interpreting environmental stimuli?

<p>It assists in controlling heart rate and digestion (A)</p> Signup and view all the answers

What does the text suggest about the possibility of trauma-inducing environments disappearing?

<p>They may persist indefinitely (C)</p> Signup and view all the answers

What is encouraged as a method for addressing ongoing traumas within communities?

<p>Turning towards each other for support (A)</p> Signup and view all the answers

What does the 'Nap Ministry' advocacy emphasize for black bodies?

<p>Reclaiming rest and self-care as vital to well-being (B)</p> Signup and view all the answers

How can trauma manifest in cultures according to the content?

<p>It reflects repeated patterns in cultural identity over time (A)</p> Signup and view all the answers

What part of the brain is activated during stressful police interactions with black bodies?

<p>Amygdala (C)</p> Signup and view all the answers

Flashcards

Sympathetic Nervous System

Part of the nervous system that triggers the "fight or flight" response, releasing norepinephrine and epinephrine to various organs.

HPA Axis

The Hypothalamic-Pituitary-Adrenal Axis; a hormonal pathway that responds to stress by releasing cortisol.

Cortisol

A stress hormone released by the adrenal cortex, part of the HPA axis.

Fight or flight

Physiological response to a perceived threat, involving increased heart rate, blood flow to muscles and reduced non-essential functions.

Signup and view all the flashcards

Alarm Stage (Stress Response)

Initial phase of the stress response; characterized by decreased resistance and increased cortisol levels.

Signup and view all the flashcards

Increased Heart Rate

The sympathetic nervous system increases heart rate to improve blood flow to muscles during stress response.

Signup and view all the flashcards

Gluconeogenesis

The process of producing glucose from non-carbohydrate sources in the liver, providing energy for the stress response.

Signup and view all the flashcards

General Adaptation Syndrome

The predictable three-stage response to stress: alarm, resistance, and exhaustion.

Signup and view all the flashcards

Allostatic Load

The cumulative wear and tear on the body from chronic stress.

Signup and view all the flashcards

African Americans

A group with significantly higher allostatic load scores than White people, notably women.

Signup and view all the flashcards

White people

A comparison group with lower allostatic load scores than African Americans, particularly women.

Signup and view all the flashcards

Allostatic load gap

The difference in allostatic load scores between racial groups.

Signup and view all the flashcards

Dose-response effect

The more stress, the greater the allostatic load and the higher the risk of disease.

Signup and view all the flashcards

Weathering

Cumulative stress from racism and sexism in African American women.

Signup and view all the flashcards

Trauma

A distressing event that overwhelms an individual's coping mechanisms.

Signup and view all the flashcards

Acute event

A sudden, short-term event.

Signup and view all the flashcards

Prolonged stress

Ongoing stressors over a period of time.

Signup and view all the flashcards

Financial and education status

Factors that did not affect the observed allostatic load differences

Signup and view all the flashcards

Stress Response

The body's physiological reaction to perceived threat, involving the release of adrenaline, cortisol, and norepinephrine.

Signup and view all the flashcards

Allostatic Load

The cumulative effect of chronic stress on the body, leading to physiological changes and potential health risks.

Signup and view all the flashcards

Trauma's Impact

Trauma can manifest in individuals, families, or cultures, shaping characteristics and behaviors over time.

Signup and view all the flashcards

White Body Supremacy

The belief that white bodies are superior and the standard to which other bodies are compared.

Signup and view all the flashcards

Vagus Nerve

A cranial nerve that helps regulate body responses to environmental stimuli.

Signup and view all the flashcards

White Body as Standard

The idea that interactions with white people serve as a reference point for other race.

Signup and view all the flashcards

Healing Work

Addressing trauma acknowledges its presence and impact without blaming the injured party; recognizes systemic issues.

Signup and view all the flashcards

Nap Ministry

A concept encouraging the acknowledgment of rest for Black Bodies.

Signup and view all the flashcards

Immune System Cells

Cells that defend the body against pathogens, each with specialized functions.

Signup and view all the flashcards

Immune System Development

The origins and maturation of immune system cells.

Signup and view all the flashcards

IL-1, IL-6, TNF-alpha effect

These cytokines trigger systemic responses by binding to body receptors, like fever, fatigue, and increased leukocyte production.

Signup and view all the flashcards

Cytokine fever trigger

IL-1, IL-6, and TNF-alpha affect the hypothalamus, the body's thermostat, causing fever.

Signup and view all the flashcards

Sickness behavior

A systemic response to cytokines, characterized by fatigue and listlessness, useful for conserving energy.

Signup and view all the flashcards

Leukocytosis

Increased production of white blood cells (WBCs) to combat infection.

Signup and view all the flashcards

Acute Phase Proteins

Proteins, like CRP and MBL, produced by the liver in response to inflammation, and aid in complement activation.

Signup and view all the flashcards

Cytokines and Metabolism

Cytokines stimulate fat and muscle to mobilize proteins, amino acids, and fats, increasing metabolism and energy production.

Signup and view all the flashcards

Dendritic Cells and Lymph Nodes

Cytokines act on dendritic cells to migrate to lymph nodes, potentially presenting antigens to CD4 T cells.

Signup and view all the flashcards

Interferon Release

Interferons are released from virus-infected cells.

Signup and view all the flashcards

Interferon Function

Interferons impede viral replication in uninfected cells.

Signup and view all the flashcards

Interferons are released from

Virus-infected cells.

Signup and view all the flashcards

MHC proteins

Proteins that distinguish self from non-self; part of the Major Histocompatibility Complex (MHC).

Signup and view all the flashcards

MHC class I

MHC proteins recognized by cytotoxic T cells and natural killer (NK) cells, on all nucleated cells, to detect abnormal cells.

Signup and view all the flashcards

MHC class II

MHC proteins recognised by CD4 T cells on antigen-presenting cells (APCs), to trigger an adaptive immune response.

Signup and view all the flashcards

Helper T cell activation

Antigen-presenting cells (APCs) display pathogen antigens on MHC class II molecules to activate helper T cells.

Signup and view all the flashcards

Helper T cell function

Activated helper T cells proliferate and activate B cells and other T cells, contributing to an enhanced immune response.

Signup and view all the flashcards

Antigen-Presenting Cells (APCs)

Cells like macrophages, dendritic cells, and B cells that display processed antigens on MHC molecules to activate other immune cells.

Signup and view all the flashcards

Robust immune response steps

The steps involved in effectively combating pathogens include antigen presentation by APCs, activation of helper T cells (CD4 T cells), and further amplification through activation of B and other T cells.

Signup and view all the flashcards

Study Notes

Human Stress Response

  • Humans must adapt biologically to their environment for survival.
  • Healthy stressors include demanding mental and physical activities (e.g., exercise, learning).
  • Stress is a state of tension that can disrupt homeostasis.
  • Purpose of stress is to trigger adaptation, leading to enhanced well-being.

Selye's Observations on Chronic Stress

  • Enlargement of the Adrenal Cortex: Cortisol release triggers cellular changes (hypertrophy and hyperplasia).
  • Shrinking of Lymphatic Organs: Chronic stress can impair immune function.
  • Stomach and Duodenal Ulcers: Reduced blood flow to the gastrointestinal tract during stress.

Human Stress Response Steps

  • A stressor (real or perceived) is recognized by the "thinking brain."
  • The "feeling and reacting brain" is activated, triggering the sympathetic nervous system and the release of cortisol.
  • Physical manifestations of stress response include increased blood pressure, heart rate, pupil dilation, and respiratory rate.

Brain Structures in Stress Response

  • Prefrontal cortex: Involved in judgment, insight, motivation, mood, and emotional reactions. It recognizes stressors and initiates/terminates the stress response.

General Adaptation Syndrome (GAS)

  • Alarm Stage: Initial reaction, resistance drops, cortisol increases.
  • Resistance Stage: Body adapts, resistance rises, cortisol levels decrease.
  • Exhaustion Stage: Prolonged stress, resistance drops, cortisol increases.

Black Americans and Health Issues

  • Approximately 200 Black Americans die prematurely each day due to racism and systemic issues.
  • Dr. David Williams's research correlates daily discrimination with poorer health outcomes and lower life expectancy.
  • This is exemplified by a higher allostatic load or chronic stress response in African Americans compared to Whites.

Allostatic Load

  • Allostasis is how the body adapts to chronic stress. This is different from homeostasis, which aims to maintain a constant state.
  • Allostatic load measures the physiological burden imposed by stress.
  • Measured via biomarkers (e.g., elevated blood pressure, cholesterol levels).

Trauma and Trauma Disorders

  • Trauma occurs from events overwhelming one's ability to cope emotionally.
  • PTSD and Acute Stress Disorder represent prolonged or severe trauma responses, lasting at least one month and possibly weeks, respectively.
  • Trauma symptoms can disrupt daily activities, lead to anxiety and flashbacks, potentially requiring therapy and prolonged treatment.

Immune System I

  • Immune cells originate from the pluripotent hematopoietic stem cell in the red bone marrow.
  • Myeloid progenitors create numerous cell types (e.g., erythrocytes, platelets, granulocytes).
  • Macrophages are phagocytic cells, crucial for inflammatory responses.
  • Dendritic cells present antigens to activate T lymphocytes.
  • Monocytes are circulating precursor cells that mature into macrophages.

Immune System II

  • MHC molecules are important for self-recognition and antigen presentation, enabling immune responses against foreign invaders.
  • MHC class I is present on all nucleated cells and presents normal/abnormal self-antigens.
  • MHC class II is found on immune cells (e.g., antigen-presenting cells) to present foreign antigens.
  • Activated T and B cells target specific pathogens through clonal expansion and selection.
  • Plasma cells produce antibodies, which neutralize pathogens and activate complement system.

Studying That Suits You

Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

Quiz Team

Related Documents

Patho Exam PDF

More Like This

Untitled Quiz
55 questions

Untitled Quiz

StatuesquePrimrose avatar
StatuesquePrimrose
Untitled Quiz
18 questions

Untitled Quiz

RighteousIguana avatar
RighteousIguana
Untitled Quiz
50 questions

Untitled Quiz

JoyousSulfur avatar
JoyousSulfur
Untitled Quiz
48 questions

Untitled Quiz

StraightforwardStatueOfLiberty avatar
StraightforwardStatueOfLiberty
Use Quizgecko on...
Browser
Browser