Heart Lab 1

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Questions and Answers

Under what condition would the region of the heart served by a coronary vessel become ischemic?

  • If the coronary vessel is adequately dilated to meet the metabolic demands of the heart muscle.
  • If the coronary vessel is blocked due to disease or other processes, leading to a lack of blood flow. (correct)
  • If the coronary vessel is functioning normally, ensuring sufficient oxygen and nutrient supply to the heart muscle.
  • If the coronary vessel experiences a temporary spasm that reduces blood flow but does not completely block it.

What is the primary component of scar tissue that replaces damaged tissue after a myocardial infarction?

  • Adipose tissue offering insulation and energy storage.
  • Smooth muscle cells facilitating contraction and relaxation.
  • Elastic fibers providing flexibility and recoil.
  • A dense collection of collagen fibers. (correct)

How does prolonged ischemia in heart muscle lead to hypoxia?

  • Prolonged ischemia has no effect on oxygen levels in the heart muscle.
  • Prolonged ischemia increases the heart muscle's ability to efficiently use available oxygen.
  • Prolonged ischemia causes an excessive supply of oxygen to the heart muscle.
  • Prolonged ischemia reduces blood flow, leading to a lack of oxygen supply to the heart muscle. (correct)

Adequate blood flow through which vessels is most essential for the proper functioning of the heart?

<p>Coronary arteries (C)</p> Signup and view all the answers

What is the clinical consequence of a myocardial infarction if the heart can no longer function as a pump?

<p>The individual's death may occur due to the heart's inability to circulate blood. (D)</p> Signup and view all the answers

What is the distinguishing feature of the epicardium?

<p>It is a serous membrane composed of simple squamous epithelium on top of loose connective and adipose tissue. (B)</p> Signup and view all the answers

What is the primary function of the myocardium?

<p>Heart contraction. (D)</p> Signup and view all the answers

Which structural component lies directly beneath the endothelium?

<p>Endocardium (B)</p> Signup and view all the answers

What type of tissue primarily constitutes the pectinate muscles?

<p>Muscular tissue (B)</p> Signup and view all the answers

What is the role of simple squamous epithelium?

<p>To facilitate diffusion and filtration. (A)</p> Signup and view all the answers

What is the approximate length of the sinoatrial (SA) node?

<p>15 millimeters (D)</p> Signup and view all the answers

What is the primary function of the sinoatrial (SA) node?

<p>To initiate electrical impulses that control heart rate (C)</p> Signup and view all the answers

What contributes to the autorhythmicity of the sinoatrial (SA) node?

<p>Inherent leakiness to sodium and calcium ions in the sinus nodal fibers. (A)</p> Signup and view all the answers

In which part of the heart is the sinoatrial (SA) node located?

<p>Superior wall of the right atrium (D)</p> Signup and view all the answers

How do action potentials spread from the sinoatrial (SA) node to the atrial muscle wall?

<p>Through direct connections between the sinus nodal fibers and the atrial muscle fibers (D)</p> Signup and view all the answers

From a posterior view, which side would the aortic arch be pointing towards?

<p>Left (C)</p> Signup and view all the answers

Which blood vessel is closely associated with the posterior interventricular artery?

<p>Middle cardiac vein (B)</p> Signup and view all the answers

What is the location of the right coronary artery?

<p>The coronary sulcus (B)</p> Signup and view all the answers

Which vein runs alongside the left ventricle?

<p>Great cardiac vein (C)</p> Signup and view all the answers

What vessel does the coronary sinus receive blood from?

<p>Cardiac veins (C)</p> Signup and view all the answers

What action follows the passing of action potentials through the AV node?

<p>Signal transmission to the Purkinje fibers (C)</p> Signup and view all the answers

After passing through the AV node, where do action potentials travel next?

<p>Along the atrioventricular (AV) bundle (D)</p> Signup and view all the answers

What crucial step occurs after the electrical impulse descends along the bundle branches?

<p>Action potentials descend to the apex of each ventricle along the bundle branches. (A)</p> Signup and view all the answers

What heart structures are directly activated by the Purkinje fibers?

<p>The ventricular walls and papillary muscles (D)</p> Signup and view all the answers

What feature is characteristic of arteries versus veins, with regard to oxygen content?

<p>99% of the arteries carry oxygen and 99% of the veins carry deoxygenated blood. (C)</p> Signup and view all the answers

According to the $P = \frac{F}{A}$ formula, how is blood pressure affected when the area (A) gets larger?

<p>Blood pressure decreases. (B)</p> Signup and view all the answers

How does blood pressure change as arteries become smaller?

<p>Blood pressure increases in smaller arteries. (C)</p> Signup and view all the answers

What is the function of the chordae tendineae?

<p>To prevent the mitral valve from prolapsing by providing support. (C)</p> Signup and view all the answers

What is the key function of heart valves?

<p>To prevent backflow of blood into the atria. (A)</p> Signup and view all the answers

What is the significance of the suspensory ligaments on heart valves?

<p>They are crucial in preventing mitral valve prolapse by anchoring the valves in a closed position. (D)</p> Signup and view all the answers

Where is the pacemaker located?

<p>Right atrium (B)</p> Signup and view all the answers

Where is the BP the lowest?

<p>Right atrium (B)</p> Signup and view all the answers

How does the anatomy contribute to the heart's ability to pump blood to two places?

<p>The precise arrangement of valves and chambers. (A)</p> Signup and view all the answers

How many great vessels branch off of the aortic arch?

<p>Three (A)</p> Signup and view all the answers

Which heart chamber has a blood pressure of 120/80?

<p>Left ventricle (A)</p> Signup and view all the answers

What is the function of the intraventricular system?

<p>Divide ventricles and know the flow of blood. (D)</p> Signup and view all the answers

Where do arteries carry blood?

<p>Always away from the heart (B)</p> Signup and view all the answers

What are the fast neurons?

<p>Pace maker in the right atrium (B)</p> Signup and view all the answers

What distinguishes cardiac muscle ischemia from necrosis at the cellular level?

<p>Ischemia is characterized by reversible cellular injury due to lack of oxygen, and necrosis involves irreversible cell death. (C)</p> Signup and view all the answers

Why is the posterior view of the heart essential for surgical planning and interventions?

<p>It provides a comprehensive visualization of the coronary sinus and associated vessels, which are critical for bypass surgeries. (B)</p> Signup and view all the answers

What physiological consequence would arise if the simple squamous epithelium of the epicardium was replaced by stratified cuboidal epithelium?

<p>Reduced drag and increased friction during cardiac movements. (B)</p> Signup and view all the answers

If the sinus nodal fibers of the SA node lost their inherent leakiness to sodium and calcium ions, what immediate effect would this have on cardiac function?

<p>Cessation of rhythmic action potentials and cardiac arrest. (A)</p> Signup and view all the answers

How could an alteration in the structural arrangement of collagen fibers within scar tissue post-myocardial infarction affect ventricular function?

<p>Reduced ventricular elasticity, impairing both systolic and diastolic function. (A)</p> Signup and view all the answers

Flashcards

Epicardium

The smooth outer surface of the heart; a serous membrane on top of loose connective and adipose tissue.

Myocardium

The middle layer of the heart, composed of cardiac muscle cells called myocytes responsible for heart contraction.

Endocardium

The innermost layer of the heart, composed of endothelial cells and connective tissue.

Pectinate muscles

Muscular ridges in the auricles (atria) of the heart.

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Trabeculae carneae

Muscular ridges and columns on the inside walls of the ventricles.

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Sinoatrial (SA) Node

A small, flattened, ellipsoid strip of specialized cardiac muscle. Located in the superior wall of the right atrium immediately below and slightly lateral to the opening of the superior vena cava.

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Necrotic

Area of dead tissue due to lack of oxygen.

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Angina

Pain caused by lack of oxygen. Also called ischemic pain.

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Hypoxia

Lack of oxygen.

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Myocardial infarction

Heart attack.

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Scar tissue

Part of muscle that became necrotic and died.

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Great cardiac vein

A large vein on the posterior aspect of the heart, collecting blood from other cardiac veins.

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Coronary sinus

A venous sinus on the posterior aspect of the heart that receives blood from cardiac veins.

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Posterior interventricular artery

Artery running in the posterior interventricular sulcus of the heart.

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Middle cardiac vein

A vein that runs alongside the posterior interventricular artery.

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Right coronary artery

Artery supplying blood to the right side of the heart, running in the coronary sulcus.

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Study Notes

2nd Order Linear PDEs

  • The general form is given by $Au_{xx} + 2Bu_{xy} + Cu_{yy} + Du_x + Eu_y + Fu = G$, where A, B, C, D, E, F, and G are functions of (x, y).

Classification of PDEs

  • The discriminant, $\Delta = B^2 - AC$, determines the classification.
  • If $\Delta > 0$, the PDE is hyperbolic, similar to the wave equation.
  • If $\Delta = 0$, the PDE is parabolic, similar to the heat equation.
  • If $\Delta < 0$, the PDE is elliptic, similar to the Laplace equation.

Canonical Forms for Hyperbolic PDEs ($\Delta > 0$)

  • Use variables $\eta = y - r_2x$ and $\xi = y - r_1x$.
  • $r_{1,2}$ are calculated as $r_{1,2} = \frac{-B \pm \sqrt{B^2 - AC}}{A}$.
  • The transformed PDE is $u_{\xi\eta} = F_1(\xi, \eta, u, u_\xi, u_\eta)$.

Canonical Forms for Parabolic PDEs ($\Delta = 0$)

  • Use variables $\xi = x$ and $\eta = Ay + Bx$.
  • The transformed PDE is $u_{\eta\eta} = F_2(\xi, \eta, u, u_\xi, u_\eta)$.

Canonical Forms for Elliptic PDEs ($\Delta < 0$)

  • Use variables $\xi = \frac{1}{2}(y - r_1x + y - r_2x) = y + \frac{B}{A}x$ and $\eta = \frac{1}{2i}(y - r_1x - (y - r_2x)) = \frac{\sqrt{-\Delta}}{A}x$.
  • The transformed PDE is $u_{\xi\xi} + u_{\eta\eta} = F_3(\xi, \eta, u, u_\xi, u_\eta)$.

1st Law of Thermodynamics

  • The change in internal energy equals heat added minus work done: $\Delta U = Q - W$.
  • This expresses conservation of energy.
  • Internal energy ($U$) is a state function; heat ($Q$) and work ($W$) are path-dependent.
  • For an ideal gas, internal energy is $U = \frac{3}{2}nRT$.
  • Work done by a gas is $W = \int{PdV}$, and at constant pressure, $W = P\Delta V$.
  • Heat capacity is given by $Q = mc\Delta T$, where $c$ is specific heat capacity.

Heat Capacity for Ideal Gases

  • Gases have $c_p$ at constant pressure and $c_v$ at constant volume.
  • For monatomic ideal gases:
    • $c_v = \frac{3}{2}R$
    • $c_p = \frac{5}{2}R$
  • For diatomic ideal gases:
    • $c_v = \frac{5}{2}R$
    • $c_p = \frac{7}{2}R$

Thermodynamic Processes

  • Isobaric: constant pressure, $W = P\Delta V$, $\Delta U = Q - W$
  • Isochoric (isovolumetric): constant volume, $W = 0$, $\Delta U = Q$
  • Isothermal: constant temperature, $\Delta U = 0$, $Q = W$, $W = nRT\ln(\frac{V_2}{V_1})$
  • Adiabatic: no heat exchange, $Q = 0$, $\Delta U = -W$, $PV^\gamma = \text{constant}$, $TV^{\gamma-1} = \text{constant}$, where $\gamma = \frac{c_p}{c_v}$

Heat Engines

  • Heat engines convert heat into work.
  • Work done is $W = Q_H - Q_C$.
  • Efficiency is $e = \frac{W}{Q_H} = 1 - \frac{Q_C}{Q_H}$.
  • Carnot engine: a theoretical engine providing maximum possible efficiency.
  • Carnot efficiency: $e_c = 1 - \frac{T_C}{T_H}$.

Refrigerators

  • Refrigerators transfer heat from a cold reservoir to a hot reservoir.
  • Coefficient of performance is $COP = \frac{Q_C}{W} = \frac{Q_C}{Q_H - Q_C}$.
  • Carnot refrigerator: a theoretical refrigerator providing maximum possible COP.
  • Carnot COP: $COP_c = \frac{T_C}{T_H - T_C}$.

2nd Law of Thermodynamics

  • The entropy of an isolated system always increases or remains constant.
  • Entropy is a measure of disorder.
  • The change in entropy is $\Delta S = \frac{Q}{T}$.
  • For a reversible process, $\Delta S = 0$.
  • For an irreversible process, $\Delta S > 0$.
  • The 2nd Law implies heat engines can not be 100% efficient.

Fourier Transform: Linearity

  • $a f(t) + b g(t) \leftrightarrow aF(f) + bG(f)$

Fourier Transform: Time Shifting

  • $f(t - t_0) \leftrightarrow e^{-j2\pi f t_0}F(f)$

Fourier Transform: Frequency Shifting

  • $e^{j2\pi f_0 t} f(t) \leftrightarrow F(f - f_0)$

Fourier Transform: Scaling

  • $f(at) \leftrightarrow \frac{1}{|a|} F(\frac{f}{a})$

Fourier Transform: Conjugation

  • $f^(t) \leftrightarrow F^(-f)$

Fourier Transform: Duality

  • $F(t) \leftrightarrow f(-f)$

Fourier Transform: Differentiation

  • $\frac{d}{dt} f(t) \leftrightarrow j2\pi f F(f)$

Fourier Transform: Integration

  • $\int_{-\infty}^{t} f(\tau) d\tau \leftrightarrow \frac{1}{j2\pi f} F(f) + \frac{1}{2}F(0)\delta(f)$

Fourier Transform: Multiplication

  • $f(t)g(t) \leftrightarrow \int_{-\infty}^{\infty} F(\theta)G(f-\theta)d\theta$

Fourier Transform: Convolution

  • $f(t) * g(t) = \int_{-\infty}^{\infty} f(\tau)g(t-\tau)d\tau \leftrightarrow F(f)G(f)$

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