Neuronal Cell Biology (2)
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Neuronal Cell Biology (2)

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Questions and Answers

How is resting membrane potential achieved?

  • 3 Na+ in and 2 K+ out via Na+/K+ ATPase, more positive outside than inside, -70 mV inside
  • 3 Na+ out and 2 K+ in via Na+/K+ ATPase, more positive outside than inside, -70 mV inside (correct)
  • 3 Na+ in and 2 K+ out via Na+/K+ ATPase, more negative outside than inside, +70 mv inside
  • 3 Na+ in and 2 K+ out via Na+ channels and K+ channels, more negative outside than inside, +70 mv inside

    • How is depolarisation achieved?

  • Na+ channels open, and Na+ enters, threshold reaches above -55 mv, generating AP (correct)
  • K+ channels open, and K+ enters, threshold reaches above -55 mv, generating AP
  • Na+ channels open, and Na+ enters, threshold reaches below +55 mv, generating AP
  • K+ channels open, and K+ enters, threshold reaches above +55 mv, generating AP

    • What is the Refactory period?

  • More negative than +70 mV, K+ channels constricted
  • More positive than -70 mV, K+ channels restricted
  • More positive than +70 mV, Na+ channels restricted
  • More negative than -70 mV, Na+ channels constricted (correct)

    • What do the Rab proteins do in synaptic vesicle exocytosis?

    <p>Vesicle targeting</p> Signup and view all the answers

    What do SM proteins do in synaptic vesicle exocytosis?

    <p>Docking/fusion</p> Signup and view all the answers

    What do SNARE proteins do in synaptic vesicle exocytosis?

    <p>Membrane fusion</p> Signup and view all the answers

    What do NSF/SNAPs do in synaptic vesicle exocytosis?

    <p>Snare recycling</p> Signup and view all the answers

    What are the excitatory neurotransmitters in the CNS?

    <p>Glutamate -&gt; Brain, Aspartate -&gt; Spinal Cord</p> Signup and view all the answers

    What are the inhibitory neurotransmitters of the CNS?

    <p>GABA -&gt; Brain, Glycine -&gt; Spinal Cord</p> Signup and view all the answers

    Glutamate acts via

    <p>Ionotropic AMPA, kainate and NMDA receptors as well as G-protein coupled receptors</p> Signup and view all the answers

    GABA acts via

    <p>Ionotropic GABA-A receptors and G-protein-coupled GABA-B receptors</p> Signup and view all the answers

    What is an example of short-term change of synaptic plasticity?

    <p>Facilitation</p> Signup and view all the answers

    What are examples of long-term change in synaptic plasticity?

    <p>Long term potentiation and long term depression</p> Signup and view all the answers

    What is NOT a post-synaptic mechanism of synaptic plasticity?

    <p>Increased neurotransmitter in synaptic cleft</p> Signup and view all the answers

    What is a mechanism of pre-synaptic synaptic plasticity?

    <p>Probability of neurotransmitter release increased</p> Signup and view all the answers

    What is the mechanism - number of synapses entail for synaptic plasticity?

    <p>Synapse formation/elimination, and activation of 'silent synapses' with only NMDA receptors from the introduction of AMPA receptors</p> Signup and view all the answers

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