Neuronal Cell Biology (2)

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Questions and Answers

How is resting membrane potential achieved?

3 Na+ in and 2 K+ out via Na+/K+ ATPase, more positive outside than inside, -70 mV inside
3 Na+ out and 2 K+ in via Na+/K+ ATPase, more positive outside than inside, -70 mV inside (correct)
3 Na+ in and 2 K+ out via Na+/K+ ATPase, more negative outside than inside, +70 mv inside
3 Na+ in and 2 K+ out via Na+ channels and K+ channels, more negative outside than inside, +70 mv inside

How is depolarisation achieved?

Na+ channels open, and Na+ enters, threshold reaches above -55 mv, generating AP (correct)
K+ channels open, and K+ enters, threshold reaches above -55 mv, generating AP
Na+ channels open, and Na+ enters, threshold reaches below +55 mv, generating AP
K+ channels open, and K+ enters, threshold reaches above +55 mv, generating AP

What is the Refactory period?

More negative than +70 mV, K+ channels constricted
More positive than -70 mV, K+ channels restricted
More positive than +70 mV, Na+ channels restricted
More negative than -70 mV, Na+ channels constricted (correct)

What do the Rab proteins do in synaptic vesicle exocytosis?

Vesicle targeting (C) Signup and view all the answers

What do SM proteins do in synaptic vesicle exocytosis?

Docking/fusion (C) Signup and view all the answers

What do SNARE proteins do in synaptic vesicle exocytosis?

Membrane fusion (D) Signup and view all the answers

What do NSF/SNAPs do in synaptic vesicle exocytosis?

Snare recycling (D) Signup and view all the answers

What are the excitatory neurotransmitters in the CNS?

Glutamate -> Brain, Aspartate -> Spinal Cord (A) Signup and view all the answers

What are the inhibitory neurotransmitters of the CNS?

GABA -> Brain, Glycine -> Spinal Cord (B) Signup and view all the answers

Glutamate acts via

Ionotropic AMPA, kainate and NMDA receptors as well as G-protein coupled receptors Signup and view all the answers

GABA acts via

Ionotropic GABA-A receptors and G-protein-coupled GABA-B receptors Signup and view all the answers

What is an example of short-term change of synaptic plasticity?

Facilitation Signup and view all the answers

What are examples of long-term change in synaptic plasticity?

Long term potentiation and long term depression Signup and view all the answers

What is NOT a post-synaptic mechanism of synaptic plasticity?

Increased neurotransmitter in synaptic cleft (C) Signup and view all the answers

What is a mechanism of pre-synaptic synaptic plasticity?

Probability of neurotransmitter release increased (A) Signup and view all the answers

What is the mechanism - number of synapses entail for synaptic plasticity?

Synapse formation/elimination, and activation of 'silent synapses' with only NMDA receptors from the introduction of AMPA receptors Signup and view all the answers

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