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Neuronal Cell Biology (2)

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16 Questions

How is resting membrane potential achieved?

3 Na+ out and 2 K+ in via Na+/K+ ATPase, more positive outside than inside, -70 mV inside

How is depolarisation achieved?

Na+ channels open, and Na+ enters, threshold reaches above -55 mv, generating AP

What is the Refactory period?

More negative than -70 mV, Na+ channels constricted

What do the Rab proteins do in synaptic vesicle exocytosis?

Vesicle targeting

What do SM proteins do in synaptic vesicle exocytosis?


What do SNARE proteins do in synaptic vesicle exocytosis?

Membrane fusion

What do NSF/SNAPs do in synaptic vesicle exocytosis?

Snare recycling

What are the excitatory neurotransmitters in the CNS?

Glutamate -> Brain, Aspartate -> Spinal Cord

What are the inhibitory neurotransmitters of the CNS?

GABA -> Brain, Glycine -> Spinal Cord

Glutamate acts via

Ionotropic AMPA, kainate and NMDA receptors as well as G-protein coupled receptors

GABA acts via

Ionotropic GABA-A receptors and G-protein-coupled GABA-B receptors

What is an example of short-term change of synaptic plasticity?


What are examples of long-term change in synaptic plasticity?

Long term potentiation and long term depression

What is NOT a post-synaptic mechanism of synaptic plasticity?

Increased neurotransmitter in synaptic cleft

What is a mechanism of pre-synaptic synaptic plasticity?

Probability of neurotransmitter release increased

What is the mechanism - number of synapses entail for synaptic plasticity?

Synapse formation/elimination, and activation of 'silent synapses' with only NMDA receptors from the introduction of AMPA receptors

Test your knowledge on resting membrane potential, depolarization, and synaptic vesicle exocytosis. Understand the concept of refractory period and the roles of Rab proteins, SM proteins, and SNARE proteins in synaptic vesicle exocytosis.

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