Drug for anaemia
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Questions and Answers

Which form of iron preparation is required for very severe iron deficiency?

  • Ferrous fumarate
  • Polysaccharide-iron complex
  • Iron dextran (correct)
  • Ferrous gluconate

    • What are the causes of iron deficiency (microcytic) anemia?

  • Chronic blood loss
  • Increased demand
  • Inadequate dietary intake
  • All of the above (correct)

    • What is the clinical use of oral forms of iron, such as ferrous sulfate?

  • Treatment and prevention of iron deficiency anemia (correct)
  • Treatment of severe iron deficiency
  • Prevention of chronic blood loss
  • None of the above

    • What are the common adverse gastrointestinal (GI) side effects associated with iron consumption?

    <p>Constipation and nausea</p> Signup and view all the answers

    What is the antidote for acute iron toxicity?

    <p>Desferrioxamine</p> Signup and view all the answers

    What is a potential fatal complication of iron toxicity?

    <p>Anaphylaxis</p> Signup and view all the answers

    Which age group is most commonly affected by acute iron toxicity?

    <p>Young children</p> Signup and view all the answers

    What are the long-term complications associated with chronic iron toxicity?

    <p>Hemosiderosis and hemochromatosis</p> Signup and view all the answers

    Which of the following is NOT a function of folic acid?

    <p>Calcium absorption</p> Signup and view all the answers

    Besides its involvement in DNA synthesis, folic acid is also important for which metabolic process?

    <p>Amino acid metabolism</p> Signup and view all the answers

    What can folic acid deficiency during pregnancy lead to?

    <p>Neural tube defects</p> Signup and view all the answers

    Which of the following is NOT an adverse effect of folic acid?

    <p>Diarrhea</p> Signup and view all the answers

    What is the primary clinical use of folic acid preparations?

    <p>Prevention of neural tube defects</p> Signup and view all the answers

    In which medical condition can folic acid be used as prophylaxis in severe chronic anemia?

    <p>Sickle cell anemia</p> Signup and view all the answers

    What is the clinical use of Leucovorin (Folinic acid)?

    <p>Treatment and prevention of methotrexate toxicity</p> Signup and view all the answers

    Who is at risk of developing folate deficiency and may require prophylaxis?

    <p>Pregnant women</p> Signup and view all the answers

    Which of the following is a vitamin B12 preparation used for oral and parenteral administration?

    <p>Cyanocobalamin</p> Signup and view all the answers

    What medical condition can result from a deficiency of intrinsic factor (IF)?

    <p>Pernicious anemia</p> Signup and view all the answers

    What is the main cause of Vitamin B12 deficiency?

    <p>Malabsorption</p> Signup and view all the answers

    Which of the following is a clinical use of Vitamin B12 (cobalamin)?

    <p>Treatment of pernicious anemia (parenteral)</p> Signup and view all the answers

    Which of the following is NOT an adverse effect associated with vitamin B12 supplementation?

    <p>Rash and itching</p> Signup and view all the answers

    What is the clinical use of hydroxocobalamin, a form of vitamin B12?

    <p>Treatment of cyanide poisoning</p> Signup and view all the answers

    Which factor(s) promote(s) erythropoiesis?

    <p>Both Epoietin and Darbepoietin</p> Signup and view all the answers

    What is the route of administration for Epoietin and Darbepoietin?

    <p>Intravenous or subcutaneous</p> Signup and view all the answers

    What are the clinical uses of Epoietin and Darbepoietin?

    <p>All of the above</p> Signup and view all the answers

    Which adverse effect is NOT associated with the use of Epoietin and Darbepoietin?

    <p>Allergic reactions</p> Signup and view all the answers

    What is the risk associated with increased blood viscosity caused by Epoietin and Darbepoietin?

    <p>Thrombosis</p> Signup and view all the answers

    What condition can be associated with the long-term use of erythropoietin or its recombinant forms?

    <p>Iron deficiency</p> Signup and view all the answers

    Which of the following is NOT a clinical use of Sargramostim?

    <p>Enhancement of platelet aggregation</p> Signup and view all the answers

    Which of the following is an adverse effect of Sargramostim?

    <p>Enlargement of liver and spleen</p> Signup and view all the answers

    Which cells does Sargramostim stimulate the proliferation, differentiation, and functional activity of?

    <p>Neutrophils, eosinophils, monocytes, and macrophages</p> Signup and view all the answers

    Which of the following is a clinical use of Filgrastim, Pegfilgrastim, and Lenograstim?

    <p>Stimulation of granulocyte production</p> Signup and view all the answers

    What is the role of filgrastim, pegfilgrastim, or lenograstim in patients undergoing bone marrow transplantation (BMT)?

    <p>Promotion of myeloid recovery</p> Signup and view all the answers

    Which of the following is an adverse effect of Filgrastim, Pegfilgrastim, and Lenograstim?

    <p>Fever and bone pain</p> Signup and view all the answers

    Which of the following is a clinical use of Oprelvekin (Recombinant human interleukin 11)?

    <p>Prevents and treats chemotherapy-induced thrombocytopenia</p> Signup and view all the answers

    Which of the following is an adverse effect associated with Oprelvekin (Recombinant human interleukin 11)?

    <p>Allergic reaction</p> Signup and view all the answers

    What is the main function of Oprelvekin (Recombinant human interleukin 11)?

    <p>Stimulates megakaryocytopoiesis and thrombopoiesis</p> Signup and view all the answers

    Which of the following is the primary clinical use of Hydroxycarbamide?

    <p>Reduce the severity of sickle cell disease</p> Signup and view all the answers

    What are the adverse effects associated with hydroxycarbamide treatment?

    <p>Myelosuppression, nausea, and rashes</p> Signup and view all the answers

    Which cells are relatively selective targets of Hydroxycarbamide?

    <p>Red cell precursors that produce abnormal hemoglobin S</p> Signup and view all the answers

    In addition to hydroxycarbamide, what are some symptomatic and supportive treatments for haemolytic anaemias?

    <p>Blood transfusion to replace red blood cells</p> Signup and view all the answers

    What is the mechanism of action of Hydroxycarbamide?

    <p>Inhibition of DNA synthesis in red cell precursors</p> Signup and view all the answers

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