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Sildenafil Family →PDE-5 Side effects :1-Reduce Notes: 1-Taken 1 hour To treatment of inhibitors dose of sildenafil and prior to Erectile Dysfunction tadalafil, but C/I the Intercrose sexual ,...

Sildenafil Family →PDE-5 Side effects :1-Reduce Notes: 1-Taken 1 hour To treatment of inhibitors dose of sildenafil and prior to Erectile Dysfunction tadalafil, but C/I the Intercrose sexual , others in erection lasts for 4 renal dysf.2-Headache hours 3-flushing 4-dyspepsia 2-with MOA: keeps the 5-nasal congestion level of cGMP high, 6-Loss of blue/ green which produces smooth discrimination muscle relaxation 7-Hearing loss through reduction of 8-In caution with CVD intracellular Ca Priapism concentration, 9-Don’t administer with increasing blood inflow. nitrates and It a-adrenergic antagonist only works in the drugs presence of sexual (hypotension) stimulation. 3-Absorption: delayed in presence of fatty meals Vardenafil Family →PDE-5 Side effects :1-Reduce Notes: 1-Taken 1 hour To treatment of inhibitors dose of sildenafil and prior to Erectile Dysfunction tadalafil, but C/I the Intercrose sexual , others in erection lasts for 4 renal dysf.2-Headache hours 3-flushing 4-dyspepsia 2-with MOA: keeps the 5-nasal congestion level of cGMP high, 6-Loss of blue/ green which produces smooth discrimination muscle relaxation 7-Hearing loss through reduction of 8-In caution with CVD intracellular Ca Priapism concentration, 9-Don’t administer with increasing blood inflow.  nitrates and It a-adrenergic antagonist only works in the drugs presence of sexual (hypotension) stimulation. 3-Absorption: delayed in presence of fatty meals Tadalafil Family →PDE-5 Side effects :1-Reduce Notes :1-Longer half life To treatment of inhibitors dose of sildenafil and 2-Absorption is not Erectile Dysfunction =(phosphodiesterase-5 tadalafil, but C/I the impaired with food. inhibitors) others in renal dysf.2-Headache 3-flushing 4-dyspepsia 5-nasal congestion 6-Loss of blue/ green discrimination 7-Hearing loss 8-In caution with CVD Priapism 9-Don’t administer with nitrates and a-adrenergic antagonist drugs (hypotension) 10-myalgia Avanafil Family →PDE-5 Side effects :1-Reduce Notes :1-Quickest, 30 To treatment of inhibitors dose of sildenafil and mins before Erectile Dysfunction =(phosphodiesterase-5 tadalafil, but C/I the intercourse, halflife for inhibitors) others in 5hrs renal dysf.2-Headache 3-flushing 4-dyspepsia 5-nasal congestion 6-Loss of blue/ green discrimination  7-Hearing loss 8-In caution with CVD Priapism 9-Don’t administer with nitrates and a-adrenergic antagonist drugs (hypotension) Alprostadil Family→ PGE1 Acts locally, less S/E Notes :1-For Alprostadil To treatment of =(prostaglandin E2) from PDE-5inhtors with C/I to PDE-5 Erectile Dysfunction 1-Headache,2- inhibitors. Hypotension 2-Onset: suppository → 3-Penile and testicular 5-10mins pain 3-Onset:Injection → 4-Mechanical 2-25mins bleeding,5- Priapism 4-Duration: 30-60mins papaverine Family→vasodilation Side effects Notes: To treatment of -benzylisoquinolone :1-dyspepsia 1-It's a Erectile Dysfunction 2- headache benzylisoquinolone 3-vomiting derivative, 4-flushing musculotropic 5- dizziness spasmolytic with a 6-myalgia nonspecific relaxant 7-visual disturbance effect on vascular 8-increased intraocular cardiac and other pressure smooth muscles 9-nasal congestion 2-Its injected 10-hypotension intracaryenosally into 11-priapism the penis to increase blood flow to the penis and produce an erection Phentolamine Family→ vasodilation Side effects Notes:1-Its an alpha1- To treatment of & alpha1/alpha2 :1-dyspepsia and alpha2-adrenergic Erectile Dysfunction adrenergic blocker 2- headache blocking agent that 3-vomiting blocks the circulating 4-flushing epinephrine and 5- dizziness norepinephrine, 6-myalgia reducing the 7-visual disturbance hypertension that 8-increased intraocular results from pressure catecholamine effects 9-nasal congestion on the alpha receptors. 10-hypotension 2- The drug is injected 11-priapism to the penis Androgens Testosterone Side effects Notes:1- To treatment of :1-dyspepsia Beneficial for men with Erectile Dysfunction 2- headache low testosterone 3-vomiting (hypogonadism) 4-flushing 2- dosage forms : gel 5- dizziness or skin patches 6-myalgia 7-visual disturbance 8-increased intraocular pressure 9-nasal congestion 10-hypotension 11-priapism